DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exd2 and Wrn

DIOPT Version :10

Sequence 1:NP_650075.1 Gene:Exd2 / 41374 FlyBaseID:FBgn0037901 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_035851.3 Gene:Wrn / 22427 MGIID:109635 Length:1401 Species:Mus musculus


Alignment Length:541 Identity:132/541 - (24%)
Similarity:200/541 - (36%) Gaps:118/541 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 VLGFDCEW--ITVGGSRRPVALLQLSSHRGLCALFRLCHMKQIPQDLRELLEDDSVIKVGVAPQE 141
            |:|||.||  |...|.|..||::||......|.||.:..|...||.|:.|||:.|:.|.||..:.
Mouse    72 VVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVFPQGLKMLLENKSIKKAGVGIEG 136

  Fly   142 DAMKLSHDYGVGVASTLDL------RFLCVMAGHKPEGLGKLSKTHLNYTLDKHWRLACSNWEAK 200
            |..||..|:.|.:.|.::|      :..|.    :...|..|.|..|...|.|...:.||||...
Mouse   137 DQWKLLRDFDVKLESFVELTDVANEKLKCA----ETWSLNGLVKHVLGKQLLKDKSIRCSNWSNF 197

  Fly   201 TLEPKQLDYAANDALMAVAIYQKLCRDLQPKHFWQRRQLDDNSM---HNKFEPFLDVDFTKGFTL 262
            .|...|..|||.||...:.|||||            ..|.|.:.   .||.|..|.::..|  .|
Mouse   198 PLTEDQKLYAATDAYAGLIIYQKL------------GNLGDTAQVFALNKAEENLPLEMKK--QL 248

  Fly   263 NPSGSGVTRSKGSTQSKSNKWVPKKQPYRQIATRTKDFYDN-CLLQAPDGELLC----TIDRRKA 322
            |    .::.......::........:..:::....|...:| |.|:    :::|    |..|.|.
Mouse   249 N----SISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLR----KVICGPTNTETRLKP 305

  Fly   323 SWYLN--------------QNLGTH-----ISEEPFTVRLNFEPAGRAVGDVGRFYQTIKKNQCV 368
            ....|              :.:|.|     |.|||:...|:.......| ||  |...:|:.:  
Mouse   306 GSSFNLLSSEDSAAAGEKEKQIGKHSTFAKIKEEPWDPELDSLVKQEEV-DV--FRNQVKQEK-- 365

  Fly   369 VCGDRDAYIRKNVVPREYRKHFPLVMKSHTSDDVLLLCPTCHQLSNISDLRVRSKLAVQCEAPFK 433
              |:.:..|..|::..:..:                   || .:.:||:..::     ..|...|
Mouse   366 --GESENEIEDNLLREDMER-------------------TC-VIPSISENELQ-----DLEQQAK 403

  Fly   434 QEDGSVKYHD-DPQLKRVQSAGKALLHHGAKIPAAKKAEME--KTLLDYYSDQTDITEDL-LRQA 494
            :|    ||:| ..||....|...........|.:.:..|||  |:|.:..||..:.|... |...
Mouse   404 EE----KYNDVSHQLSEHLSPNDDENDSSYIIESDEDLEMEMLKSLENLNSDVVEPTHSTWLEMG 464

  Fly   495 ASVEYRVENSDYCQHGERVV---QQYRDHFGGLVELERL--WRQHFLHTMQPRFLPELWNVNHNA 554
            .:.....|..|  .||...:   |:..||.......:::  .:.:|.|:   .|.|..|.|.|: 
Mouse   465 TNGRLPPEEED--GHGNEAIKEEQEEEDHLLPEPNAKQINCLKTYFGHS---SFKPVQWKVIHS- 523

  Fly   555 DRLEVRASEGRIDKADLMVAG 575
                  ..|.|.|...:|..|
Mouse   524 ------VLEERRDNVVVMATG 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Exd2NP_650075.1 WRN_exo 62..226 CDD:176653 57/154 (37%)
WrnNP_035851.3 Interaction with WRNIP1. /evidence=ECO:0000269|PubMed:11301316 1..271 66/220 (30%)
KBM 1. /evidence=ECO:0000250|UniProtKB:Q14191 6..18
RNaseD_like 55..223 CDD:176650 57/166 (34%)
rnd <156..>344 CDD:130455 47/213 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..427 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 464..492 6/29 (21%)
recQ_fam 502..975 CDD:129701 12/47 (26%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 632..635
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q14191 952..958
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1041..1106
HRDC 1116..1194 CDD:128635
HTH_40 1223..1317 CDD:464189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1323..1401
KBM 2. /evidence=ECO:0000250|UniProtKB:Q14191 1367..1376
XLM. /evidence=ECO:0000250|UniProtKB:Q14191 1388..1401
Blue background indicates that the domain is not in the aligned region.

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