DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5276 and Cant1

DIOPT Version :9

Sequence 1:	NP_001287287.1	Gene:	CG5276 / 41373	FlyBaseID:	FBgn0037900	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_653355.1	Gene:	Cant1 / 246272	RGDID:	628743	Length:	403	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	191/417 - (45%)
Similarity:	250/417 - (59%)	Gaps:	41/417 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RDWRSALRTPTYRIGNRTV----------RFNYHFALLI---VCAFVLVLLF------YFARQGS 67
            |:|...:.:....:|...|          ||...:.:::   |.|.:|.||:      ...|...
  Rat     9 REWNEPMHSLRISVGGLPVLASMTKATDPRFRPRWRVILTSFVGAALLWLLYSHHQTPVSGRPPI 73

  Fly    68 HSSSDGYWLRRSYTDARSLDNGGPVVQAYNATYPLTSPMVLRGGVINYRIAMIADLDTSSKVSKG 132
            |::.:  |..|...           :..||.||||:.|....|| |.||||:||||||.||..:
  Rat    74 HNAHN--WRLRQER-----------ISQYNDTYPLSPPQRTPGG-IRYRIAVIADLDTGSKAQE- 123

  Fly   133 DGSSTWRSYLKKGYLTYTVARSEIQISWDDGAPIVLESAFALKGRGMELSELVTFNGRLLTFDDR 197
              .:||.|||||||||.:.:...:.:.||.... ||||..|.||||||||:|:.|||:|.:.|||
  Rat   124 --ENTWFSYLKKGYLTLSDSGDRVSVEWDKDRG-VLESHLAEKGRGMELSDLIVFNGKLYSVDDR 185

  Fly   198 TGLIYEIVNDKPIPWVILLDGDGHSAKGFKAEWATVKEQTLYVGSMGKEWTTSAGDFENNNPMYV 262
            ||:||:|...|.:|||||.||||...|||||||..||::.||||.:||||||:.|:..|.||.:|
  Rat   186 TGVIYQIEGTKAVPWVILSDGDGAVEKGFKAEWLAVKDEHLYVGGLGKEWTTTTGEVVNENPEWV 250

  Fly   263 KAITPSGEVRSLNWVDNFKQLRLQSMQITWPGYMIHESGTWSEERNRWFFLPRRCSKEKYNETKD 327
            |.:...|.|...|||.::..|| .:..|..|||:||||..||:...||||||||.|.|:|:|.:|
  Rat   251 KVVGHRGSVEHENWVSSYNALR-AAAGIQPPGYLIHESACWSDTLQRWFFLPRRASHERYSERED 314

  Fly   328 EHMGCNVLVSADESFTNVETVRLDPENTTPTHGFSSFKFLPGTDDSIIVALKSEELNGKTATFIT 392
            |..|.|:|:||.:.|.::...::..  ..||||||||||:|.|||.|||||||||.||:.||::.
  Rat   315 ERKGSNLLLSAAQDFRDISVRQVGA--LVPTHGFSSFKFIPNTDDQIIVALKSEEDNGRIATYVM 377

  Fly   393 AFDIAGKTLLPETRIETDYKYEGFEFI 419
            ||.:.|:.|||||:|.: .||||.|||
  Rat   378 AFTLDGRFLLPETKIGS-VKYEGIEFI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5276	NP_001287287.1	Apyrase	123..418	CDD:283687	156/294 (53%)
Cant1	NP_653355.1	Apyrase	116..403	CDD:399223	156/294 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343723
Domainoid	1	1.000	310	1.000	Domainoid score	I1280
eggNOG	1	0.900	-	-		E1_KOG4494
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69460
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2284
OMA	1	1.010	-	-		QHG59066
OrthoDB	1	1.010	-	-		D1126948at2759
OrthoFinder	1	1.000	-	-		FOG0007083
OrthoInspector	1	1.000	-	-		oto96773
orthoMCL	1	0.900	-	-		OOG6_105728
Panther	1	1.100	-	-	LDO	PTHR13023
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5171
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810