DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5276 and CANT1

DIOPT Version :9

Sequence 1:	NP_001287287.1	Gene:	CG5276 / 41373	FlyBaseID:	FBgn0037900	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_001153244.1	Gene:	CANT1 / 124583	HGNCID:	19721	Length:	401	Species:	Homo sapiens

Alignment Length:	423	Identity:	193/423 - (45%)
Similarity:	250/423 - (59%)	Gaps:	41/423 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EHAEHSPRAMYMRDWRSALRTPTYRIGNRTV----------RFNYHFALLI---VCAFVLVLLFY 61
            ||.|          |..::.:....:|...|          ||...:.:::   |.|.:|.||.
Human     7 EHPE----------WNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC- 60

  Fly    62 FARQGSHSSSDGYWLRRSYTDARSLDNGGPVVQAYNATYPLTSPMVLRGGVINYRIAMIADLDTS 126
                 ||..:.|   |....:|.:...|......||.||||:.|.....| |.||||:||||||.
Human    61 -----SHRPAPG---RPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAG-IRYRIAVIADLDTE 116

  Fly   127 SKVSKGDGSSTWRSYLKKGYLTYTVARSEIQISWDDGAPIVLESAFALKGRGMELSELVTFNGRL 191
            |:..:   .:||.|||||||||.:.:..::.:.||.... ||||..|.||||||||:|:.|||:|
Human   117 SRAQE---ENTWFSYLKKGYLTLSDSGDKVAVEWDKDHG-VLESHLAEKGRGMELSDLIVFNGKL 177

  Fly   192 LTFDDRTGLIYEIVNDKPIPWVILLDGDGHSAKGFKAEWATVKEQTLYVGSMGKEWTTSAGDFEN 256
            .:.|||||::|:|...|.:|||||.||||...|||||||..||::.||||.:||||||:.||..|
Human   178 YSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVN 242

  Fly   257 NNPMYVKAITPSGEVRSLNWVDNFKQLRLQSMQITWPGYMIHESGTWSEERNRWFFLPRRCSKEK 321
            .||.:||.:...|.|...|||.|:..|| .:..|..|||:||||..||:...||||||||.|:|:
Human   243 ENPEWVKVVGYKGSVDHENWVSNYNALR-AAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQER 306

  Fly   322 YNETKDEHMGCNVLVSADESFTNVETVRLDPENTTPTHGFSSFKFLPGTDDSIIVALKSEELNGK 386
            |:|..||..|.|:|:||...|.::....:..  ..||||||||||:|.|||.|||||||||.:|:
Human   307 YSEKDDERKGANLLLSASPDFGDIAVSHVGA--VVPTHGFSSFKFIPNTDDQIIVALKSEEDSGR 369

  Fly   387 TATFITAFDIAGKTLLPETRIETDYKYEGFEFI 419
            .|::|.||.:.|:.|||||:|.: .||||.|||
Human   370 VASYIMAFTLDGRFLLPETKIGS-VKYEGIEFI 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5276	NP_001287287.1	Apyrase	123..418	CDD:283687	155/294 (53%)
CANT1	NP_001153244.1	Apyrase	113..400	CDD:310576	155/294 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149837
Domainoid	1	1.000	309	1.000	Domainoid score	I1333
eggNOG	1	0.900	-	-		E1_KOG4494
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69460
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2409
Isobase	1	0.950	-	0	Normalized mean entropy	S3945
OMA	1	1.010	-	-		QHG59066
OrthoDB	1	1.010	-	-		D1126948at2759
OrthoFinder	1	1.000	-	-		FOG0007083
OrthoInspector	1	1.000	-	-		oto89659
orthoMCL	1	0.900	-	-		OOG6_105728
Panther	1	1.100	-	-	LDO	PTHR13023
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3756
SonicParanoid	1	1.000	-	-		X5171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750