DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5270 and zfyve26

DIOPT Version :9

Sequence 1:NP_731570.2 Gene:CG5270 / 41370 FlyBaseID:FBgn0037897 Length:2243 Species:Drosophila melanogaster
Sequence 2:XP_021336194.1 Gene:zfyve26 / 324565 ZFINID:ZDB-GENE-030131-3286 Length:2555 Species:Danio rerio


Alignment Length:2738 Identity:607/2738 - (22%)
Similarity:1001/2738 - (36%) Gaps:842/2738 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLNLLPKDQRQIFEIFIQWL-NGKSSGPIQLHQNALLTVLQASPYPALQLLQLLHERSKLHIGQI 75
            |.:||.:.|.::....|.:| ||..|....|....:..:.:....||       .:|::..:.|:
Zfish   148 LRSLLTRQQPRLCHSLISFLSNGDPSRDHTLQDAFIQHLTEQVKVPA-------KDRNREWVEQV 205

  Fly    76 ISTL-------------LRQLLDGDVASPRSLCVLANFPASVLEASTLRQKLMTRLVVDSITSEH 127
            .|.|             |..|.:|..|:                    |:.|||         |.
Zfish   206 CSVLALAPWGSDRSGAQLEPLWEGLWAA--------------------REGLMT---------EE 241

  Fly   128 LMLTMLARSDGQLLDDLLHEQQLTMR----AQCSEAAPTKLLVLWLALNEREHFVASVCQHLKD- 187
            .:|..|.|...|.|  |:......:|    ...:||..|:     :.|.:.|..:..:|.| || 
Zfish   242 RILGCLLRPQSQAL--LMAYSSTALRLLKDKLLAEAPHTQ-----VDLPDLERVMLGLCCH-KDK 298

  Fly   188 --------FKCFQDVTLRNNLLILRLANEFALGSQTLEELGCLEKLLAEFDVSAVPEKLQEVHGF 244
                    |:|...                  |...||::     ||...|: ...|:..::...
Zfish   299 RLAWKAIYFECLSS------------------GKHFLEQV-----LLTGLDL-IKREEFSKLETL 339

  Fly   245 FYADFQRLSTLLNFL-----RPREISKTLRVDALLRAP------------------GVLPLIHEN 286
            .:::||.||.||..|     :..|.:|||......|.|                  |||....:|
Zfish   340 LHSEFQPLSRLLLLLGWMHCQSLESAKTLLTVLHHRQPQSNDSALSDLACTLSCQLGVLEWCTQN 404

  Fly   287 GIHFKH----QELHRLIEDT--YKWQQLTPALKCHHQEEVEILSYYTALCHV--------YDVVL 337
            .....|    ..||.|...:  |....|||..|....:.:|:|........|        .::.|
Zfish   405 NPGISHDALLSHLHMLDHHSALYVLHCLTPLAKFEEHKVLELLQRTGDPSQVDSPSSSVQRNITL 469

  Fly   338 DQGEQTTKTKLVQLSVQLRQLHQLGAL---------------------CS--------------- 366
            .:|....|..|..:||..|.....|:|                     ||               
Zfish   470 FRGFCAMKYALYAISVNARTHAHTGSLDCEPLHELQTEAAQEDETAEGCSNLFQHYLSECQLYLE 534

  Fly   367 ---------LLEDIFLLVFL-------------------RWEQLEPNSQRKGEDGEN--DEEDDE 401
                     |||:||.|:||                   ..|..:|.|.::....|:  ..|::.
Zfish   535 AVPALFRLELLENIFSLLFLSDSDFTQQTSTATETQPYTNTETSKPKSTKEVNTAEHFLKAENEG 599

  Fly   402 QYVDDDVASPPRPTAVHSQRTRYGFICRSASLHALFTFLKAFV--TKKIHSQDYK---------- 454
            :.:|:  .:...|...|......||:.....:..:...::..:  ...:..:|.:          
Zfish   600 ERMDE--LNQINPQLGHLTSGCRGFLVDLNVMEGILRLVREGLEGVCGVGQEDGRALGADVELAE 662

  Fly   455 ------SAPEQQGRFQRLVDAISEALWKLGVLQKI----EQSLLKSAPSISCLLEPDQLLQLVQL 509
                  :|.....|.|||....:||.|:|.::...    ...|...:|.      |...|.|.:.
Zfish   663 SLGCSVTAETFSARLQRLSKYTAEAQWRLQIVTSNHGNGNDGLYLPSPL------PSPALPLKRQ 721

  Fly   510 HSTAKKKASSDDESRERSNHASSLNRRKARRQRRAVSFSGGVAGKASADGGLAMEQLRARAQLLS 574
            .|     .||...||.|..|....:.|....:|:     .|....:::|||:.:..:        
Zfish   722 GS-----GSSGTSSRRRRKHHRHRSERHVSSERQ-----NGEVSTSTSDGGVCVSVV-------- 768

  Fly   575 GSGSRKNSSVTSPCERS---IIPKMLSTPEQLAIMALALKNFNDVKKIIETFHLEHSQLNRELHF 636
                 ...:.|.||..|   ::|.|||.||.|.|..:...|:.:.:::|..:.||:|:...||.|
Zfish   769 -----CRGTETCPCGGSHSWLVPAMLSPPESLLIACIRRGNYIEAQQVIAMYGLENSECAGELVF 828

  Fly   637 ME------------QQQLVKQKLSAIYANYQIL---------EGQQANSGETTVEQIKGVAAKGF 680
            |:            :|::..|.||...::.:.|         ..:..:|...|::.|...||.|.
Zfish   829 MDRYREVLIELAQVEQKIESQSLSTSSSSSEGLGTLGATPAGRTRMGSSSRLTLKSIGSAAAAGM 893

  Fly   681 ELSKIISVVDN-----------FSQAHRLQQ----SPE-LKALIQRHNTSAQQGF---------- 719
            ....|..|.|.           ...::.|.|    ||: ::.|::..:.:|...|          
Zfish   894 AFYSISDVADRLMSTPSRPIPCLEDSYWLSQCTIDSPDFVRPLVEELSPAAMAAFDLSCCQCQLW 958

  Fly   720 -----LQQFEERNLNALI----------------------------------------------- 732
                 |.:..||.|::.:                                               
Zfish   959 KTSRQLLETAERRLSSFLEARGVRVDPKVPHANGIRGFPSVLQQISKILNKTSTNKGMSKTDCNG 1023

  Fly   733 ----ICDLI------VNLGFNREITSNLLLVIRRQQQQKKGG----DEASNTPGSSELGAMNLLQ 783
                :|...      |.|..:..:|...:.:.:...|:.:..    ..|:||...|.:|: |||.
Zfish  1024 EENAVCSPFGCSAQEVLLSCHSTLTEESITIQQNLNQRLEVTLQTLSSATNTSVDSLVGS-NLLT 1087

  Fly   784 NLCECMRLLERSGQQAALNELLSLKSYPLRPAVLALQLQREAAFQTLYQKEPSEYSHGHELRSNA 848
            .|.|          ||||.: ..|..:|:|.|:..|       .|.|.|..|.......:     
Zfish  1088 ALAE----------QAALKQ-SELDCHPVRTAMKQL-------LQYLDQLCPLVPDGAPD----- 1129

  Fly   849 NQFQQLRSRHNYYARFCTYVQQLARLLQLRDPNLEYHTT--------QLLRNDPYEVIGELIYEC 905
                    |.:|...|..||..||.:| :|....|..:|        .||...|.:::..|:::.
Zfish  1130 --------RPDYIRSFFDYVNVLASVL-VRSLGSEDQSTVVKLGNPLLLLLQSPAQLLSHLLFDR 1185

  Fly   906 GITPLEIEASV--AALHLNLVHVI--------------ALN------------ICP--------Q 934
            .::|..:.:.:  ..|.|::..|:              |:|            .||        |
Zfish  1186 QVSPDRVLSLLQQERLRLSVQQVVVQRCCETLPLWDSRAVNFSQRVSGLNGGAFCPASIASILQQ 1250

  Fly   935 LSEEPTKRL----PRVVAPQKQESIHNYISQHNQLLAHILLAIQLGSLPDGDADVDF-------S 988
            .:::.:..|    |...:....||   .:|..:...|...|:....|.........|       |
Zfish  1251 YAQDCSPSLDLSDPTTTSDPSSES---EVSVEDVSAASTSLSTSPPSPSSSSPSSSFLLTPSALS 1312

  Fly   989 FL-------GHLVHLSE-----VNVLASVYDGNRVLAALNAYKLESARLDQLVTDQEQ------- 1034
            ||       ..|..||.     ..|.:|.:.|      |.:|...|.| .:.|.|.||       
Zfish  1313 FLKSRSPLVAALACLSASRGGVTRVTSSGWSG------LPSYFRGSGR-KEAVLDGEQISREGEA 1370

  Fly  1035 ------LLQILL-------LGMSGQTD---------SPNRHKSRIDQLIGDLIEKDPRN------ 1071
                  :|::.|       ||:|.:.|         .|         ::|.|......|      
Zfish  1371 LLKNFPILRMYLRTMAEPVLGVSLEADEGLGVALCGKP---------VVGMLFSGLQGNAAQAMA 1426

  Fly  1072 ---IHLVVHMGNLGQRAQLLKEH----------------FTRIPSSQQAKEL------------- 1104
               ....::.|:|.:...||:.:                ||.:..|..|::|             
Zfish  1427 AEAFQQALNNGDLNRALDLLELYAQPCSQEGALRDKLLAFTALQESSSAEQLFRVRDWELRGRVV 1491

  Fly  1105 ---IER--------TLHHRSAAKSIPTALRSELEHTLSDITIYARVSAL---LKFESWPQAYDFG 1155
               ::|        .||...:.::....||.:|:....::.:|.|:..|   |.:|:|.:..:..
Zfish  1492 LQGLDRWPLQQCLDLLHFCLSDQNTKDPLREQLQQRKQELDMYQRMLRLQPSLPWETWQELREES 1556

  Fly  1156 RQTPNVIFEQLLQRRRFGLCLEWSRVVYLAGSAGQQRVC--LLTLLD--------ALLE-LRD-- 1207
            .:.|..:|.|:|:.|.|.||.:|.::..::..:|.|...  ||.||:        .||| |.|  
Zfish  1557 TKNPESVFSQMLEAREFELCAQWVQLYSVSDQSGMQLQTEHLLYLLEHNHTEEAFQLLEALSDSM 1621

  Fly  1208 GEELDESLLGIVEMFPPNPLVNFLDTHKDKFRSLPLLQWVIDYLEGH-------ARDPRLYRNYQ 1265
            |.|:.|..|                   |:...|....::.|||..|       ||...::. ..
Zfish  1622 GLEVSERAL-------------------DRRPGLAACHFLSDYLTLHFQSQMTPARRRHIHA-LH 1666

  Fly  1266 LSLEFLRQMDTNERSPFWKLIRHPLLIVEQLVMNARFELLGKLLDAARSKLLKERPLGPCPYCFD 1330
            |..:.|..:....|..::.|:..|||::||::||.:.:.....:...||.||.:           
Zfish  1667 LGSKVLLTLPEASRQDYFSLLSDPLLMLEQMLMNLKVDWAAVAITTLRSLLLAQ----------- 1720

  Fly  1331 KTGHVYDVQSSAGLGSGAGETPAKIRFQLGQTTSEAFILLNFNSYQQDHFVGQDCLDLLLRIYAS 1395
                      .||:                 ||..                    :|.||..||.
Zfish  1721 ----------DAGI-----------------TTQH--------------------IDTLLADYAR 1738

  Fly  1396 KALDY-----------HVANVRAA-----------------SEPSSLGTDVH----------NSL 1422
            ||||:           .|.:::.|                 ..||:.||.:.          ..:
Zfish  1739 KALDFPYAPREWSRSDSVISLQDAFLQCPAQESCPSSPSHTPPPSTGGTPMQTPSSERRPSGKKI 1803

  Fly  1423 DSLCGAFVMPKQAPNRQQWTRDEEASHCMCCRRAAFTMLMRRHHCRRCGRVVCYACSTHRIRIPE 1487
            ..|...|..|::.|:|:.|..|.:...||.|:|..|||..||||||||||:||::||:.::.:..
Zfish  1804 RPLATPFTPPEKTPDRKDWIPDHKQHICMVCQRERFTMFNRRHHCRRCGRLVCHSCSSKKMAVAG 1868

  Fly  1488 LYDELEVRICNDC----AACSTPAKDQGDGTSSERS---AISG-----QVSKSSGRSDSCKWQLS 1540
             :|| .||:|:.|    ...|....:||:...|..|   .::|     :||:.       :::||
Zfish  1869 -FDE-PVRVCDQCYNFFHTDSDEELEQGEVAGSPSSIDEVLNGVLSLPEVSRK-------QYRLS 1924

  Fly  1541 GIITHDKLLREEFSYEHAPSVALSLSILRNHVEQRSCVDLLLFHCRKLEKLIVPNPEVDYGLVAK 1605
            .....::.|:.||.||.|||.:|.::||..|.:..:|...|:.|||.|.:.:. |||||..|:..
Zfish  1925 PNPAENQQLKSEFYYEQAPSASLCVAILTLHSDHAACGQQLIDHCRSLSRKLT-NPEVDARLLTD 1988

  Fly  1606 MINCLAFAAKV-------RGAPGELENIREHSEIIMAVVQQGCESLIPTGPLNNHN----LRKLA 1659
            ::..|.|:||:       ...|...::.....:::..:|....: .||:  |::..    :.:|.
Zfish  1989 VMRQLLFSAKLMFVNAGCTQEPALCDSYISKVDVLKILVTANYK-YIPS--LDDIQETAAVTRLR 2050

  Fly  1660 DALVEAEHWTLALEVHLKCGFATTGVMAAHGLACLRAGCYDAAREKFAHCM-TRLSSEQLNSSIC 1723
            :.|:|.|::.||:||..|......||..|..:|.|:||....|||||..|: ..:...|||    
Zfish  2051 NQLLELEYYQLAVEVSTKSALDPNGVWQAWAMASLKAGNLSGAREKFVRCLKAPVDRNQLN---- 2111

  Fly  1724 KNIFGVASTEAVLLPRKRPQRGPALLQEILQLIAAIPQV---QTQPETLHRASLIRSSNTSLASL 1785
                                .||.|||||:|.:.:..::   ||..|.:                
Zfish  2112 --------------------HGPRLLQEIIQHLESTVKLTLSQTMDEDI---------------- 2140

  Fly  1786 FTRRREPYVQPRPLQEPALNIMNALAGLKNLAKGQYGGQMPTSEESRRQERGF-EESLHYVLTYG 1849
                                    ||.|:.|.:.......|...||:.|...| :|.|.|:.|||
Zfish  2141 ------------------------LASLRELEEALSDSAPPEGTESKVQRCNFHQECLFYLFTYG 2181

  Fly  1850 SHADILTFLMRREELRAALRYWQHQQLDADLFIHHIFYPQLANGGLNVLMDELQQLDDAQFTAWR 1914
            :|..:::|.:|.:.|:.||.|.|::....|:|:..||.|.|..|.|..|...|:.||....| |.
Zfish  2182 THLSLISFYLRHDCLKDALTYLQNKGCSDDVFLEGIFQPCLERGRLGALQGLLENLDPTLET-WG 2245

  Fly  1915 LPLLQTCRHLEQQQQLSSLYQLQLLLKDPIRASMTCVKFYALQCENFQKLHANAQHLLSALRHLQ 1979
            ..||..|:.|:::....||||||..:.|.|||:|||::|::...:::.:|....:.|:.|..||:
Zfish  2246 RYLLSACQLLQRRGHYHSLYQLQQFMMDHIRAAMTCIRFFSHGAQSYLQLGEQQRWLIRAKEHLR 2310

  Fly  1980 GELDMAEWEHLQRQQARRNSVSSTASVRGACFAMQMDARALNGHINTIRRQLEVAKFLDKCEREQ 2044
                    .:||.||:||.|.||:       |..:|.:..::.||:||..||||.:||.:|| ..
Zfish  2311 --------TYLQEQQSRRKSHSSS-------FRKKMSSTDVSRHIHTIELQLEVTRFLHRCE-SS 2359

  Fly  2045 PPDEPLRTIQTLKQIRLESSRGTLPTLFEGAADRIQI---CILILMCGKNIDEGFGLAYGIMQDF 2106
            |....:.:..|        .....||||..:..::.:   |:.:::.||||:||||:||.::|||
Zfish  2360 PSKTAVGSTYT--------GNSAPPTLFGNSPMKVDVACKCLTVMLGGKNIEEGFGIAYRVIQDF 2416

  Fly  2107 KLAALKVFGATAKYLSRNQRLGEVERLLDCIGSNNGGDISTESDEILSIAINAAVHSSAPETKQM 2171
            :|.||.|:....:.|.|.::...|.:|..|:| .:|.....:.|.|:...::.|  ..:|...:.
Zfish  2417 QLEALAVYIRVGQRLVRQRQYSSVRQLHKCVG-ESGTASKHDCDAIVLSCVSVA--DKSPADAKE 2478

  Fly  2172 LDRLIKRIGSVELRVSSYIYIGQLKSAYLLANKHDRLAD---IRRILRQAELTGQVHIKKLCDMK 2233
            |:.||....:.|.::.:|:...:|::|||.|.|...:..   |:.::|.||.:|...:..:|...
Zfish  2479 LETLILECKNPENKIKAYLQCSKLRAAYLQAVKLKLVKATPLIQEVMRAAESSGDSVMHDICRQW 2543

  Fly  2234 LQLSAAPT 2241
            |.....|:
Zfish  2544 LSEHQEPS 2551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5270NP_731570.2 PHD_SF 1441..1500 CDD:304600 28/58 (48%)
zfyve26XP_021336194.1 FYVE_ZFY26 1822..1881 CDD:277263 29/60 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 260 1.000 Domainoid score I1945
eggNOG 1 0.900 - - E1_KOG1811
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 411 1.000 Inparanoid score I1840
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1237900at2759
OrthoFinder 1 1.000 - - FOG0007305
OrthoInspector 1 1.000 - - oto40678
orthoMCL 1 0.900 - - OOG6_105845
Panther 1 1.100 - - LDO PTHR46591
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4836
SonicParanoid 1 1.000 - - X6192
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1312.860

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