DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5270 and ZFYVE26

DIOPT Version :9

Sequence 1:NP_731570.2 Gene:CG5270 / 41370 FlyBaseID:FBgn0037897 Length:2243 Species:Drosophila melanogaster
Sequence 2:XP_016876613.1 Gene:ZFYVE26 / 23503 HGNCID:20761 Length:2545 Species:Homo sapiens


Alignment Length:2754 Identity:603/2754 - (21%)
Similarity:1014/2754 - (36%) Gaps:861/2754 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EDQQEENMQQLLNLLPKDQRQIFEIFIQ---------------WLNGKSSGPIQLHQNALLTVLQ 51
            ||.|.:..:.:|       .:::|...|               |....||..:    :.|..:|:
Human   109 EDLQGDIPENIL-------EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAV----SVLWDLLR 162

  Fly    52 ASPYPALQLLQLLHERSK----LH--IGQIISTLLRQLLDGDVASPRSLCVLANFPASVLEA--- 107
            .||.||..||:||.|...    .|  :...:..|:|:.|       |:|....:.|..|::|   
Human   163 QSPQPAQALLELLLEEDDGTGLCHWPLQNALVDLIRKAL-------RALQGPDSVPPGVVDAIYG 220

  Fly   108 --STLR---QKLMTRLVVDSITSEHLM---LTMLARSDG------QLLDDLLHE----------- 147
              .|||   :.|...|        ||:   |....|::|      :||..|||:           
Human   221 ALRTLRCPAEPLGVEL--------HLLCEELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGH 277

  Fly   148 ---QQLT---MRAQCS-EAAPTKL------LVLWLALNEREHFVASVCQHLKDFKCFQDVTLRNN 199
               :::|   .||..| :.:|..|      |.|:...|..|.:..:....|.:.|.|.:..|...
Human   278 TYAEKVTEKPPRATASGKVSPDHLDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTA 342

  Fly   200 LLILRLANEFALGSQTLEELGCLEKLLAEFDVSAVPEKLQEVHGFFYADFQRLSTLLNFL----- 259
            |.:|:        .:....||||                      ...:|:.||.||..|     
Human   343 LTLLK--------EEDFPNLGCL----------------------LDREFRPLSCLLVLLGWTHC 377

  Fly   260 ----RPREISKTLR------VDALLR-------------------APGVLP----LIHENG--IH 289
                ..:.:.:||.      .|.|||                   :...:|    |.|.:|  .|
Human   378 QSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCIQQSSNPIPKRDLLYHLHGGDSH 442

  Fly   290 FKHQELHRLI-------EDTYKWQQLTPALK------------CHHQEEVEILSYYTALC----H 331
            .....||.|.       ||..|..|..||..            ..|..:.:.|:.|...|    .
Human   443 SVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYA 507

  Fly   332 VYDVVLDQGE----QTTKTKLVQ---------------------LSVQLRQLHQLGALCS----- 366
            :|.:.::..:    |..|..|.:                     .|..|.:..|.  |||     
Human   508 IYALCVNSHQHSQCQDCKDSLSEDLASATEPANDSLSSPGAANLFSTYLARCQQY--LCSIPDSL 570

  Fly   367 ---LLEDIFLLVFLRWEQLEPNSQRKGEDGENDE------------EDDEQYVDDDVASPPR--- 413
               |||:||.|:.:....|.|......:..|:|:            .:..|:    :|.|.|   
Human   571 CLELLENIFSLLLITSADLHPEPHLPEDYAEDDDIEGKSPSGLRSPSESPQH----IAHPERKSE 631

  Fly   414 --------------PTAVHSQ-RTRY-------------------GFICRSASLHALFTFLKAFV 444
                          |:.|.:: :..|                   ||:   |...|:..||: .:
Human   632 RGSLGVPKTLAYTMPSHVKAEPKDSYPGPHRHSFLDLKHFTSGISGFL---ADEFAIGAFLR-LL 692

  Fly   445 TKKIHSQDYKSAPEQ---------------QGRFQRLVDAISEALWKLGVLQKIEQSLLKSAPSI 494
            .:::.....:|.||:               |.|..||...:|||.|:                  
Human   693 QEQLDEISSRSPPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWR------------------ 739

  Fly   495 SCLLEPDQLLQLVQLHSTAKKKASSDDESRER----SNHASSLNRRKARRQRRAVSFSGGVAGKA 555
                           |........|:::...|    :.|.|....|:.||.:......|......
Human   740 ---------------HKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLE 789

  Fly   556 SADGGLAMEQLRARAQLLSGSGSRKNSSVTSPCERSIIPKMLSTPEQLAIMALALKNFNDVKKII 620
            |....|:..........:||.....:.....| :.|:||.|.|.||.|....:...||.:..:::
Human   790 STSSELSTSTSEGSLSAMSGRNELHSRLHPHP-QSSLIPMMFSPPESLLASCILRGNFAEAHQVL 853

  Fly   621 ETFHLEHSQLNRELHFMEQQQLVKQKLSAIYANYQILEGQQAN----------SGETTVEQIKGV 675
            .||:|:.|..:.||.|||:.|.|.|:|:.:...   :|.|.::          ||.:|::.|...
Human   854 FTFNLKSSPSSGELMFMERYQEVIQELAQVEHK---IENQNSDAGSSTIRRTGSGRSTLQAIGSA 915

  Fly   676 AAKGFELSKIISVVDNFSQAH-----RLQQ-----------SPELKALIQRHNTSAQQGF----- 719
            ||.|.....|..|.|......     .||:           :..|:.:::..:..|...|     
Human   916 AAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACS 980

  Fly   720 ----------LQQFEERNLNALI------ICDLIVNL----GFN---REITSNLLLVIRRQQQQK 761
                      |.:..||.||:.:      |..:::|.    ||.   ::|:.:|..::....|.|
Human   981 QCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMSASQTK 1045

  Fly   762 ------KGGDEASNTPGSSELGAMNLLQNLC------ECMRLLERSGQQ-----AALNELLSLKS 809
                  |||       |........||| :|      :|:.......||     .:|.|.|.|..
Human  1046 SESVEEKGG-------GPPRCSITELLQ-MCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPE 1102

  Fly   810 YPLRPAVLALQLQREAAFQTLYQKEPSEYSHGHE-----LRSNANQFQQLRSRH-NYYARFCTYV 868
             |..|.:.:  |..:||     ||.|...:|..:     |:.|..:.....||. :|...|.:|.
Human  1103 -PRTPPLSS--LVEQAA-----QKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYC 1159

  Fly   869 QQLARLLQLRDPNLEYHTTQLLRNDPY--------EVIGELIYECGITPLEIEASVAALHLNL-V 924
            ..||.:| |:..:.|....::...:|:        :::..|::|..:.|..:.|.:|..:|:| |
Human  1160 STLAAVL-LQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSV 1223

  Fly   925 HVIALNIC--------------------------------------------PQLSEEPTKRLPR 945
            ..:.::.|                                            |:.:|.||.....
Human  1224 PQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKP 1288

  Fly   946 VVAPQKQ------ESIHNYISQHNQLLAHILLAIQLGSLPDGDADVDFSFLGHLVHLSEVNVLAS 1004
            ..:|:..      .|...::...::|||.:..   ||:.|             .:.:|:.::...
Human  1289 YSSPRDSSLPALTSSALAFLKSRSKLLATVAC---LGASP-------------RLKVSKPSLSWK 1337

  Fly  1005 VYDGNR--VLAALNAYKLESARLDQLVTDQEQLLQILLLG---------MSGQTDSPN------- 1051
            ...|.|  .|||     .:.||..:.:.:|..|.:..||.         ..||:.:.|       
Human  1338 ELRGRREVPLAA-----EQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASL 1397

  Fly  1052 --------------------------RHKSRIDQL-------IGDL-----------IEKDPRNI 1072
                                      |..||..||       :.||           :..|....
Human  1398 STVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGW 1462

  Fly  1073 HLVVHMGNLGQRAQLLKEHFTRIPSSQQAKELIERTLHHRSAAKSIPTALRSELEHTLSDITIYA 1137
            ..:..:.:...|::|..:...|.| .:...|::...:    :..::...|:.||:..|:::.:|.
Human  1463 QYLFPVKDASLRSRLALQFVDRWP-LESCLEILAYCI----SDTAVQEGLKCELQRKLAELQVYQ 1522

  Fly  1138 RVSALLKFESWPQAYDFGRQT--------PNVIFEQLLQRRRFGLCLEWSRVVYLAGSAGQQRVC 1194
            ::   |..:|.|...|:  ||        |:.:...:|:.:.:.||.||..:..:      .|..
Human  1523 KI---LGLQSPPVWCDW--QTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPI------PREH 1576

  Fly  1195 LLTL----LDALLELRDGEELDESLLGIVEMFP-PNPLVNFLDTHKDKFRSLPLLQWVIDYLEGH 1254
            |::|    |..|||.||    .:..|.::...| |...:...:...|:..||....::.:||..|
Human  1577 LISLHQKHLLHLLERRD----HDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTH 1637

  Fly  1255 -------ARDPRLYRNYQLSLEFLRQMDTNERSPFWKLIRHPLLIVEQLVMNARFELLGKLLDAA 1312
                   .|...:...| :..:.|..:....|:.:..|..:||.::|||:||.:.:.....:...
Human  1638 FYGQLTAVRHREIQALY-VGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTL 1701

  Fly  1313 RSKLLKERPLGPCPYCFDKTGHVYDVQSSAGLGSGAGETPAKIRFQLGQTTSEAFILLNFNSYQQ 1377
            :..|:.:                                      ::|.|..|            
Human  1702 QQLLVGQ--------------------------------------EIGFTMDE------------ 1716

  Fly  1378 DHFVGQDCLDLLLRIYASKALDYHVANVRAASEPSSLGTD--------VHNSLD----------- 1423
                    :|.||..||.||||:.... |......||.||        ||.:.|           
Human  1717 --------VDSLLSRYAEKALDFPYPQ-REKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAE 1772

  Fly  1424 ---------------SL----------CGAFVMPKQAPNRQQWTRDEEASHCMCCRRAAFTMLMR 1463
                           ||          ...||.|...|.|.||..||..|.||.|.|..|||..|
Human  1773 FSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNR 1837

  Fly  1464 RHHCRRCGRVVCYACSTHRIRIPELYDELEVRICNDC-AACSTPAKDQGDGTSSERSAISGQVSK 1527
            |||||||||:||.:|||.:: :.|...|...|:|:.| :.|:   ||..:..|.:..|:....::
Human  1838 RHHCRRCGRLVCSSCSTKKM-VVEGCRENPARVCDQCYSYCN---KDVPEEPSEKPEALDSSKNE 1898

  Fly  1528 SS--------GRSDSCKWQLSGIITHDKLLREEFSYEHAPSVALSLSILRNHVEQRSCVDLLLFH 1584
            |.        .::|..:|.|......::|:|.||.||.|||.:|.::||..|.:..:|...|:.|
Human  1899 SPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEH 1963

  Fly  1585 CRKLEKLIVPNPEVDYGLVAKMINCLAFAAKVRGA-PGELENIR---------EHSEIIMAVVQQ 1639
            |.:|.|.:. |||||.||:..::..|.|:||:... .|:.:::.         :...|::|...:
Human  1964 CCRLSKGLT-NPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYR 2027

  Fly  1640 GCESLIPTGPLNNHNLRKLADALVEAEHWTLALEVHLKCGFATTGVMAAHGLACLRAGCYDAARE 1704
            ...||...  |....:.:|.:.|:|||::.|.:||..|.|..|||...|.|:|||:||...||||
Human  2028 HVPSLDQI--LQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAARE 2090

  Fly  1705 KFAHCM-TRLSSEQLNSSICKNIFGVASTEAVLLPRKRPQRGPALLQEILQLIAAI--PQVQTQP 1766
            ||:.|: ......|||                        .|..|:|::::.:.:.  |.|..|.
Human  2091 KFSRCLKPPFDLNQLN------------------------HGSRLVQDVVEYLESTVRPFVSLQD 2131

  Fly  1767 E----TLHR-ASLIRSSNTSLASLFTRRREPYVQPRPLQEPALNIMNALAGLKNLAKGQYGGQMP 1826
            :    ||.. .:.:|:.:.|||.:                |...|||          ..|     
Human  2132 DDYFATLRELEATLRTQSLSLAVI----------------PEGKIMN----------NTY----- 2165

  Fly  1827 TSEESRRQERGFEESLHYVLTYGSHADILTFLMRREELRAALRYWQHQQLDADLFIHHIFYPQLA 1891
                       ::|.|.|:..|.::..|::|.:|...||.||.:..:::...::||..||.|...
Human  2166 -----------YQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYK 2219

  Fly  1892 NGGLNVLMDELQQLDDAQFTAWRLPLLQTCRHLEQQQQLSSLYQLQLLLKDPIRASMTCVKFYAL 1956
            :|.|:.|.:.|:.:|.. ..:|...|:..|:||:::.....||:||..:||.:||:|||::|::.
Human  2220 SGKLHTLENLLESIDPT-LESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSH 2283

  Fly  1957 QCENFQKLHANAQHLLSALRHLQGELDMAEWEHLQRQQARRNSVSSTASVRGACFAMQMDARALN 2021
            :.:::.:|......||.|..||:          :..|:..|    |:...:...|..:|.|..::
Human  2284 KAKSYTELGEKLSWLLKAKDHLK----------IYLQETSR----SSGRKKTTFFRKKMTAADVS 2334

  Fly  2022 GHINTIRRQLEVAKFLDKCEREQPPDEPLRTIQTLKQIRLESSRGT-------LPTLFEGAADRI 2079
            .|:||::.|:||.:||.:||                      |.||       |||||.....::
Human  2335 RHMNTLQLQMEVTRFLHRCE----------------------SAGTSQITTLPLPTLFGNNHMKM 2377

  Fly  2080 QICILILMCGKNIDEGFGLAYGIMQDFKLAALKVFGATAKYLSRNQRLGEVERLLDCIGSNNGGD 2144
            .:...:::.|||:::|||:|:.::|||:|.|...:...|:.|...::..|:::||.|: |.:|..
Human  2378 DVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCV-SESGMA 2441

  Fly  2145 ISTESDEILSIAINAAVHSSAPETKQMLDRLIKRIGSVELRVSSYIYIGQLKSAYLLANK--HDR 2207
            ..::.|.||...:.|  ....|  .|.|:.||:.|.:.:.:|.:|:...:|:||||:|.|  |.|
Human  2442 AKSDGDTILLNCLEA--FKRIP--PQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSR 2502

  Fly  2208 -LADIRRILRQAELTGQVHIKKLC 2230
             .|.::::.:.|:.:|...::.:|
Human  2503 ATALVQQVQQAAKSSGDAVVQDIC 2526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5270NP_731570.2 PHD_SF 1441..1500 CDD:304600 30/58 (52%)
ZFYVE26XP_016876613.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1851
eggNOG 1 0.900 - - E1_KOG1811
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 409 1.000 Inparanoid score I1882
Isobase 1 0.950 - 0 Normalized mean entropy S8680
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1237900at2759
OrthoFinder 1 1.000 - - FOG0007305
OrthoInspector 1 1.000 - - oto91253
orthoMCL 1 0.900 - - OOG6_105845
Panther 1 1.100 - - LDO PTHR46591
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6192
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.870

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