Protein Alignment CG5270 and zfyve26

DIOPT Version :9

• Sequence 1: NP_731570.2
• Gene: CG5270 / 41370
• FlyBaseID: FBgn0037897
• Length: 2243
• Species: Drosophila melanogaster
• Sequence 2: XP_002937253.3
• Gene: zfyve26 / 100492179
• XenbaseID: XB-GENE-1005056
• Length: 2555
• Species: Xenopus tropicalis
• Alignment Length: 2690
• Identity: 603/2690 - (22%)
• Similarity: 1031/2690 - (38%)
• Gaps: 748/2690 - (27%)

  Fly     4 QQEENMQQLL--NLLPK----------DQRQIFEIFIQWLNGKSSGPIQLHQNALLTVLQASPYP 56
            |:.||.:::.  .|.||          ...::.:..|.:|...:|.|..|..|.||  |..|...
 Frog   130 QESENRREISGPRLSPKTISSLRTFLGHNPRLVQALIGFLLIDNSHPSALEYNHLL--LNISVDY 192

  Fly    57 ALQLLQLLHER---SKLHI----GQIISTLLRQLLDGDVASP--RSLCVLANFPASVLEASTLRQ 112
            .|.|::.|.|.   |:.|:    .||...|.....:|::.:.  |.|| ...|.|.....|.||:
 Frog   193 LLDLIKSLQEMKHGSQEHLEKVAEQIYGVLGTMHFNGELQASELRHLC-QELFRACWSHGSILRE 256

  Fly   113 KLMTRLVVDS-----------ITSEHLMLTMLA-RSDGQ-LLDDLLHEQQLTMRAQC--SEAAPT 162
            :.:.:.::..           :.||::...:.| ||.|: ...:|...::..:...|  .:..|.
 Frog   257 EQIQQCMLRKQNYALVSLYGIVASENMKALITAQRSPGKGAACELSDSERAILALFCDPEQVNPW 321

  Fly   163 K----------------LLVLWLALNEREHFVA---------------------SVCQHLKDFK- 189
            |                :|:..|||.:||.|..                     :.||.::..|
 Frog   322 KTAYFYCLSTGKHFLEQILLTALALLKREDFTTLSMLLRNEFKPLRRLLVLLGWTHCQSIESAKM 386

  Fly   190 --CFQDVTLRNNL-----LILRLANEFALGSQTLEELGCLEKLLAEFDVSAVPEK--LQEVHGFF 245
              |    ||.:|.     |:|:   ||..|  .:.::..||..: :.:...:|:|  ||.::
 Frog   387 LLC----TLHHNKDLCNDLVLK---EFCEG--LMYQVEALEWCI-QHNSQVIPKKEILQHLY--- 438

  Fly   246 YADFQRLSTLL---NFLRPREISKTLRVDALLRAPGVLPLIHENGIHFKH--------------- 292
              :..|.|.|.   :..|..|:::...::.|.|.|........|.:...|
 Frog   439 --NLDRHSALYILHHLTRLPELNEEEVLELLQRGPASAGEDSSNQLDSHHLISQRNTVVFQAFCA 501

  Fly   293 --QELHRLIEDTYKWQQ---LTPALKCHHQEEVEILSYYTALCHVYDVVLDQGEQTTKTKLVQLS 352
              ..::.|..:.::..|   ..|.|.....|:.|..|            :.:.|..|...|....
 Frog   502 IKYSMYALCVNAHRHTQCRDCLPHLLSGSSEDTEFPS------------VPEKETLTFQDLSAFF 554

  Fly   353 VQ-------LRQLHQLGALCSLLEDIFLLVFLRWEQL--EPNSQRKGEDGENDEE---------- 398
            ||       ..||........::|:||.|:|.....|  || ||.:....|::||
 Frog   555 VQYFTKCQYYLQLLPAPFRLEVMENIFSLLFASISDLNKEP-SQSEDYPAEDEEEVKVNLRTEGL 618

  Fly   399 DDEQYVDDD----VASP--------------------------------------PRPTAV---H 418
            :.:..:|..    |:||                                      |||..:   |
 Frog   619 ELDSSLDKGECLAVSSPIQTTLNKDCSFLGADLSGISNGSLTSTVENAQRTHSILPRPNYLDLKH 683

  Fly   419 SQRTRYGFICRSASLHALFTFLKAFVTK-------KIHSQDYK-------SAPEQ--QGRFQRLV 467
            ..:...||:.....|......||..|.:       ..|:::.|       |..::  ..|..:|.
 Frog   684 FTKGLSGFLADEVVLDQFLKMLKDHVDEPKDCSPWSEHNKEIKLLECMNLSVTKETFSSRVLQLS 748

  Fly   468 DAISEALWKLGVL---QKIEQSLLKSAPSISCLLEPDQLLQLVQLHSTAKKKASSDDESRERSNH 529
            ..||:..|:..|:   :..|:.|:.|.                :.:.|.|   :|....|.|.|:
 Frog   749 KYISDTQWRYRVVMSNRNAEEELITSR----------------RPYRTYK---ASGFRRRSRKNN 794

  Fly   530 ASSLNRRKARRQRRAVSFSGGVAGKASADGGLAMEQLRARAQLLSGSGSRKNSSVTSPCERSIIP 594
            ..|  :::.......:|.|...|...||.|. |..::::|.:.|                  :||
 Frog   795 RGS--KKQMESTSSELSTSESCASNLSAIGE-ADPRIQSRQRNL------------------LIP 838

  Fly   595 KMLSTPEQLAIMALALKNFNDVKKIIETFHLEHSQLNRELHFMEQQQLVKQKLSAIYANYQILEG 659
            .|||.||.|.:..:...|:.:..::...|:|:.:....||.|||:.|.|.::||::   .|.:|.
 Frog   839 MMLSPPESLLMSCILRGNYPEAHQVALMFNLQSTSSYGELIFMERYQDVVRELSSV---EQRIEN 900

  Fly   660 QQANSG-------ETTVEQIKGVAAKGFELSKIISVVDN----------------FSQAHRLQQS 701
            |.:.||       .:|::.|...||.|.....|..|.|.                :.:..||::.
 Frog   901 QSSESGTRKLSNSRSTLQAIGSAAAAGMVFYSISDVTDKLLAPAEGPIPTLHDDFWVKGARLEKC 965

  Fly   702 PELKALIQRHNTSAQQGF---------------LQQFEERNLNALIIC-----DLIVNLGFNREI 746
            ...:.::...|.||...|               |.:..||.||..:..     |.|::   :.|.
 Frog   966 DPWRHVLDELNPSAMAAFDLACTQAHLWKTCRQLLETTERRLNCTLETKGRKPDCILD---HPEG 1027

  Fly   747 TSNLLLVIRRQQQQKKGGDEASNTPGSSELGAMNLLQNLCECMRLLERSGQQAALN--ELLSLKS 809
            ...|..|:   ||..|..:.||::.|.:||.               ||...|...|  ||.. ..
 Frog  1028 IRGLPAVL---QQLSKIMNYASSSLGQTELE---------------ERINSQFKCNITELFH-TC 1073

  Fly   810 YP-------LRPAVLALQLQR-----EAAF----------QTLYQK---EPSEYSHGHELR---- 845
            ||       :|...|..:|::     :||.          |:|..:   :|.:. ..|.:|
 Frog  1074 YPVLNDECIVRDITLGYELEQILTLLKAAISSHEPKGNPVQSLMDQLSMKPQDV-QVHPVRQQMD 1137

  Fly   846 ---SNANQFQQLRSRH----NYYARFCTYVQQLARLL------QLRDPNLEYHTTQ---LLRNDP 894
               :|.::..:..:.|    :...:|.||:..:|:::      :| ||:||.....   ||...|
 Frog  1138 LLLTNLDEIAKSLNGHGPKPDNVKKFFTYLDTMAKVIIQSINTEL-DPSLEVKVGNPFVLLHQKP 1201

  Fly   895 YEVIGELIYECGITPLEIEASV--AALHLNLVHVIALNICPQLS--------------------- 936
            .::|..:::|..:.|..:.:.:  ..|.:::..|||...|..:|
 Frog  1202 SQMISHMLFERQVPPERLSSLLDKENLGVSVEQVIADYCCEPMSFCNVRKHKHAQCVMRSIGQIT 1266

  Fly   937 --------------------EEPTK---RLPRVVAPQKQE-----SIHNYISQHNQLLAHI--LL 971
                                :|..|   ..|...||...:     |..|::...:::.|.:  |.
 Frog  1267 WHCVELTLPDMEINIPSCGHDEEDKIGASSPASPAPDHNQRYLTASALNFLKSKSRIAAAVACLS 1331

  Fly   972 AIQ--------------LGSLPDGDAD------------VDFSFLGHLVHL---------SEVNV 1001
            |.:              :||..:...|            ::|..|...:..         ||.|.
 Frog  1332 AAKSQKPTKSGLSWMELIGSKKESPLDMENIAKECDSLLLEFPVLQRFISAMSAPFQDCPSEGNG 1396

  Fly  1002 LASVYDGNRVLAALNAYKLESARLDQLVTD--QEQL--------LQILLLGMSGQTDSPNRHKSR 1056
            .||...| :..:||....|.|...:.:||:  ||.:        ||||.|           :...
 Frog  1397 FASTLCG-KPCSALALLGLHSPTANAVVTEAFQEAVSAKEWSRPLQILDL-----------YSYD 1449

  Fly  1057 IDQLIG--DLI-------EKDPRNIHLVVHMGNLGQRAQLLKEHFTRIPSSQQAKELIERTLHHR 1112
            :..|:|  |.|       |||.......|...:|  |::|......:.|    ....|| .|.:.
 Frog  1450 LKDLVGIRDAILSCAAAEEKDGHRYLFAVKDPSL--RSKLALRFLHKWP----LDACIE-ILSYC 1507

  Fly  1113 SAAKSIPTALRSELEHTLSDITIYARVSALLKFESWPQAYDFG---RQTPNVIFEQLLQRRRFGL 1174
            .....|...|:.||::..|::.:|.::.:|.:..||....:..   ::.|:.:...:|..:.:.|
 Frog  1508 MCEPDIDEDLKLELQNKRSEMAVYQKILSLKEDSSWVTWQELKKDCKEDPHTVLSIMLDAKDYTL 1572

  Fly  1175 CLEW----------------SRVVYLAGSAGQQRV--CLLTLLDALLELRDGEE--LDESLLGIV 1219
            |.||                ..:::|.|:...::.  .|..:.|..|.....|:  |.:|.:...
 Frog  1573 CEEWGHFYPVPVELLISLHCEHLLHLLGNQDTEKAIQLLQRIEDQSLRCAISEQALLQQSSIFAC 1637

  Fly  1220 EMFPPNPLVNFLDTHKDKFRSLPLLQWVIDYLEGHARDPRLYRNYQLSLEFLRQMDTNERSPFWK 1284
            ..|....|.||.::..:..|           ||        .|:..:..:.|..:.....|.:..
 Frog  1638 HFFSEYLLHNFHNSMSEAKR-----------LE--------IRDVYMGSKILLALPEGAHSSYKH 1683

  Fly  1285 LIRHPLLIVEQLVMNARF-------ELLGKLLDAARS--------KLLKERPLGPCPYCFDKTGH 1334
            |:..|||::|||:||.:.       :.:.:.||...|        |||       |.|    .|.
 Frog  1684 LVSSPLLLLEQLLMNMKIDWAAVAVQTIKQFLDELESSFSTEDVDKLL-------CTY----AGK 1737

  Fly  1335 VYDVQSSAGLGSGAGETPAKIRFQLGQTTSEAFILLNFNSYQQDHFVGQDCLDL----------- 1388
            ..|                 |.|...:..|::.|.   ||        :.|..|
 Frog  1738 ALD-----------------IPFSFRERRSDSVIR---NS--------ESCGQLAEPESTSVPST 1774

  Fly  1389 ---LLRIYASKALDYHVANVRAASEPSSL-GTDVHNSLDSLCGAFVMPKQAPNRQQWTRDEEASH 1449
               |....|.:.:|:.    |..:.|||. ...:.:|.:     ||.|::.|.:.||..||....
 Frog  1775 PEPLTPSVADRVVDWS----RFQTPPSSQEKRRIKSSPE-----FVPPEKPPAKTQWIPDEREVT 1830

  Fly  1450 CMCCRRAAFTMLMRRHHCRRCGRVVCYACSTHRIRIPELYDELEVRICNDC----AACSTPAKDQ 1510
            ||.|:...|||..||||||||||:||.:||..|: :.|...|...|:|:.|    :|......:.
 Frog  1831 CMVCKNERFTMFNRRHHCRRCGRLVCSSCSMKRM-VVEGCRENPARVCDQCHAYFSANINKMDED 1894

  Fly  1511 GDGTSSERSAIS---GQVSKSSGRSDSCKWQLSGIITHDKLLREEFSYEHAPSVALSLSILRNHV 1572
            .|.|.:||...|   .::.|.| ::...:|.|:.....:::.|.||.||.|||.:|..:||..|.
 Frog  1895 SDYTEAERPGGSLDLAEILKLS-KAAELQWCLTVNEQENEVERSEFYYEQAPSASLCSAILNLHS 1958

  Fly  1573 EQRSCVDLLLFHCRKLEKLIVPNPEVDYGLVAKMINCLAFAAK---VRGAPG-ELENIREHS--- 1630
            :...|...|:..|..|.|.:. |||:|..|:..::..|.|:||   |:.|.. :|.....:|
 Frog  1959 KSEECGYQLIERCCMLSKDLT-NPEMDSRLLLDIMKNLLFSAKMIFVKAARSQDLALCDSYSSKV 2022

  Fly  1631 ---EIIMAVVQQGCESL----IPTGPLNNHNLRKLADALVEAEHWTLALEVHLKCGFATTGVMAA 1688
               :|::|...|...||    .|...:      :|.:.|:|.|::.||:||..|.|....||..|
 Frog  2023 DLLKILVAASYQEIPSLDEIVRPAAVI------RLRNQLLEVEYYNLAIEVSTKTGLDPAGVWQA 2081

  Fly  1689 HGLACLRAGCYDAAREKFAHCMTRLSSEQLNSSICKNIFGVASTEAVLLPRKRPQRGPALLQEIL 1753
            .|:|||::.....|||||:.|:                      :|.|.|.::..| |.||.:::
 Frog  2082 WGMACLKSDNLPGAREKFSRCL----------------------KAPLDPNQKNPR-PTLLDDVV 2123

  Fly  1754 QLIAAIPQVQTQPETLHRASLIRSSNTSLASLFTRRREPYVQPRPLQEPALNIMNALAGLKNLAK 1818
            |.:          |:..:..|:.:.:...|:|  :..:..::|..:....:
 Frog  2124 QYL----------ESAAQPILLVNDDDYFATL--KELKATLKPHCIWFEMM-------------- 2162

  Fly  1819 GQYGGQMPTSEESRRQERGFEESLHYVLTYGSHADILTFLMRREELRAALRYWQHQQLDADLFIH 1883
                     |||..:..:.::|.|||:.|||:|..|:.|.|||:.:|.||.:..:::...|:||.
 Frog  2163 ---------SEEKHQNNKYYQECLHYLHTYGTHLSIIQFYMRRDRMREALLHLLNKECPRDIFIE 2218

  Fly  1884 HIFYPQLANGGLNVLMDELQQLDDAQFTAWRLPLLQTCRHLEQQQQLSSLYQLQLLLKDPIRASM 1948
            .||.|...:|.|.:|.:.|:.| |....:|...|::.|:||:|:...:.||:||..:||.|||:|
 Frog  2219 GIFVPSYESGKLQMLENLLESL-DTTLESWSTYLIEACKHLQQKNFYNILYELQQFMKDHIRAAM 2282

  Fly  1949 TCVKFYALQCENFQKLHANAQHLLSALRHLQGELDMAEWEHLQRQQARRNSVSSTASVRGACFAM 2013
            ||::|::.:.:::::|..|...|:.:..||:..|     :.:.|...:|....:        |..
 Frog  2283 TCIRFFSYKAKSYRELGDNMNWLIKSKEHLKTCL-----QEIPRGTNKRKYHDT--------FRK 2334

  Fly  2014 QMDARALNGHINTIRRQLEVAKFLDKCEREQPPDEPLRTIQTLKQIRLESSRGTLPTLFEGAADR 2078
            :|....::.||||:..|:.:.|||.:||..       .|.||:|:        ..||||..:...
 Frog  2335 KMSNSDISRHINTVELQMAITKFLQRCESS-------GTSQTIKK--------PPPTLFGDSGMI 2384

  Fly  2079 IQICILILMCGKNIDEGFGLAYGIMQDFKLAALKVFGATAKYLSRNQRLGEVERLLDCIGSNNGG 2143
            |.:...:::.|||::||||||:.::|||:|.|.||:|...|.|...:...|:.:|:.|: |.:|.
 Frog  2385 IDVACRVILGGKNVEEGFGLAFRVIQDFQLDAAKVYGKVCKQLVGQEHYAEILQLVKCV-SESGI 2448

  Fly  2144 DISTESDEILSIAINAAVHSSAPETKQMLDRLIKRIGSVELRVSSYIYIGQLKSAYLLANKHDRL 2208
            ....:.|:||...|......|..|    |::||:.:.|.|.::.:::....::||||.|.|.:..
 Frog  2449 AAENDCDQILLRCIEEMADMSPDE----LEKLIQGMRSDENKIKAFLTCRMMRSAYLTAVKQEHE 2509

  Fly  2209 ADIRRILRQAELTGQVH---IKKLC 2230
            ..|:.:....:.|.|::   ::.:|
 Frog  2510 RAIQLVQEVWQATRQINDTVVQGIC 2534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5270	NP_731570.2	PHD_SF	1441..1500	CDD:304600	28/58 (48%)
zfyve26	XP_002937253.3	FYVE_ZFY26	1822..1882	CDD:277263	29/60 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2034
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1871
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0007305
OrthoInspector	1	1.000	-	-		oto105030
Panther	1	1.100	-	-	LDO	PTHR46591
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4836
SonicParanoid	1	1.000	-	-		X6192
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100