DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAPT and mapt

DIOPT Version :9

Sequence 1:	XP_005257419.1	Gene:	MAPT / 4137	HGNCID:	6893	Length:	862	Species:	Homo sapiens
Sequence 2:	XP_012808014.2	Gene:	mapt / 779920	XenbaseID:	XB-GENE-986948	Length:	709	Species:	Xenopus tropicalis

Alignment Length:	900	Identity:	351/900 - (39%)
Similarity:	456/900 - (50%)	Gaps:	229/900 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGD-TDAGLKESPLQTPTEDGSEEPGSETS 64
            ||:..|:::.:.||.        :|.....::....|| .....:||.::.||       .:...
Frog     1 MADHYQDYDSVGDHT--------RDGSAQQIYTGGSGDHILESSQESVIRLPT-------AAHGD 50

Human    65 DAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEELRV 129
            ||.|  ..||:        |.|:...:|.|..|||||||||||:|.|||.:|.||..:..  |..
Frog    51 DAAS--VQEDL--------ANGEAVRSQGHAGIPEGTTAEEAGVGHTPSQQDRAAEEIAL--LAA 103

Human   130 PGRQRKAPERPLANEISAHVQPGPCGEASGVSGPCLGEKEPEAPVPLTASLPQHRPVCPAPPPTG 194
            .|::.:.....:...:....:.....|..|::|...||.:.: ...|::.:.:..........|.
Frog   104 AGQEEEYEMDTMEETLKITAKDQTHAENYGITGDVDGESQND-ETALSSGMVESAVEEDYYKETN 167

Human   195 GPQEPSLEWGQKGGD-WAEKGPAFPKPATTAYLHTEPESGKVVQEGFLREP--GPPGLSHQLMSG 256
            | :|.:||..:...: |.|:                      :.||.:.:.  .||....|.:|.
Frog   168 G-KEVNLEICEDDTEGWEEQ----------------------IDEGIIMQDSVAPPKGGEQELSS 209

Human   257 MPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEE 321
            :       |.|     |.:|||.|             |..|                      |:
Frog   210 V-------EQP-----QTNGTGAE-------------HIFL----------------------ED 227

Human   322 VDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPAS 386
            ....:|.:|       |..|.||......|...|.:.|:  :..|....:|:|
Frog   228 NQHKKDTEE-------PFMAIPANSFPVGQIRPRASVSV--YQVEIDANIPID------------ 271

Human   387 EPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLG-EDT 450
                       .::||.|..                          |.||      |..:. |..
Frog   272 -----------SKEAPCEDV--------------------------GIPG------GTKVDTERA 293

Human   451 KEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTR-SSAKTLKNRPCL 514
            .|..|..|.::.||.. .|.||||||..||.  .:.|..|.|.:|.|:.||: ..||..|:|...
Frog   294 TEETLKSPRKRMPAHG-SGIPVSRVPVPKAH--EQEKHETDSQEKGAQISTKHPPAKNAKSRLYT 355

Human   515 SPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTS--RT-----GSSG--AKEMKLKGADG-- 568
            .|:             .||::..:.||||. .|||.|  ||     |..|  |:..:.|.|.|
Frog   356 VPQ-------------KSPSITSKSPSSPA-ASSVRSIQRTSLGAVGQPGVTARLHRAKEAGGPE 406

Human   569 --KTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSS-----------------GEPPKSGD 614
              |::::..|.|        .:|:||||||...||||||:                 .|.||||:
Frog   407 SAKSQLSASRNA--------TSASRIPAKTSSIPKTPPSAVRRDQRKPPPSGAKPDRAESPKSGE 463

Human   615 RSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQ--TAPVPMPDLKNV 677
            |||||||||||||..||   |..|||||||||:||:|||||||:|||||||  |:|..|||||||
Frog   464 RSGYSSPGSPGTPTGRS---SSQTPPTREPKKIAVIRTPPKSPASAKSRLQPVTSPAAMPDLKNV 525

Human   678 KSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSK 742
            :|||||.:|::||||||||||::||:|||:||||||||||:||:||||::||.:||:||:.:|||
Frog   526 RSKIGSIDNIRHQPGGGKVQIVHKKIDLSSVQSKCGSKDNLKHMPGGGTIQITHKPIDLTHITSK 590

Human   743 CGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKT 807
            |||.|||||:||||.||||||||:| |::||||||||||||.||||.||||:|||.|||||||||
Frog   591 CGSFGNIHHRPGGGNVEVKSEKLEF-DKIQSKIGSLDNITHTPGGGAKKIESHKLMFRENAKAKT 654

Human   808 DHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 862
            |||||||||||..||:||||.||||||:|||:|.|||||:||||:||||||||||
Frog   655 DHGAEIVYKSPGQSGETSPRRLSNVSSSGSINMTDSPQLSTLADQVSASLAKQGL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPT	XP_005257419.1	Tubulin-binding	<673..694	CDD:278828	15/20 (75%)
		Tubulin-binding	696..725	CDD:278828	22/28 (79%)
		Tubulin-binding	727..756	CDD:278828	19/28 (68%)
		Tubulin-binding	758..788	CDD:278828	24/29 (83%)
mapt	XP_012808014.2	PHA03378	<199..520	CDD:223065	142/459 (31%)
		PTZ00449	<383..>512	CDD:185628	67/139 (48%)
		Tubulin-binding	<521..543	CDD:395337	16/21 (76%)
		Tubulin-binding	544..573	CDD:395337	22/28 (79%)
		Tubulin-binding	575..605	CDD:395337	20/29 (69%)
		Tubulin-binding	606..635	CDD:395337	24/29 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I19457
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74962
Inparanoid	1	1.050	362	1.000	Inparanoid score	I9671
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166235at32523
OrthoFinder	1	1.000	-	-		FOG0005553
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	1	1.000	-	-		X4510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090