DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAPT and tau

DIOPT Version :9

Sequence 1:	XP_005257419.1	Gene:	MAPT / 4137	HGNCID:	6893	Length:	862	Species:	Homo sapiens
Sequence 2:	NP_733224.2	Gene:	tau / 326116	FlyBaseID:	FBgn0266579	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	867	Identity:	210/867 - (24%)
Similarity:	323/867 - (37%)	Gaps:	222/867 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    18 YGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDE 82
            ||.|  ||:.|..:...|    |..:::...|:.:|........:....:|.|.......|....
  Fly     2 YGTG--KDRSGQEIISPQ----DYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESS 60

Human    83 GAPGKQAAAQPHTEIP-----EGTTAEEAGIGDTPSLEDEAAGHVTQEELRV---PGRQRKAPER 139
            .:..::...||..::.     ..||::.|..|         :..|:::::|.   |..|..|.|.
  Fly    61 DSSVERKKEQPSAQLSTDYTNSNTTSDSASYG---------SDSVSKQQIRSQQNPEYQNNAYEA 116

Human   140 PLANEISAHVQPGPCGEASGVSGPCLGEKEPEAPVPL--------------TASLPQHRPVCPAP 190
            |  .:..:.:||.....|:..|.....::.|  |..|              |.|....||...:|
  Fly   117 P--RDDRSQLQPQRSQPATDYSAYERQQRPP--PTTLDYTTGYNAPPKDRTTLSRTNSRPTLSSP 177

Human   191 PPTGGPQEPSLEWGQKGGDWA---EKGPAFPKPATTAYLHTEPESGKVVQEGFLREPGPPGLSHQ 252
            .|. ....|:.|:.:...::.   :..||...|                      :|.||....:
  Fly   178 NPK-LQSIPNTEYVRPPQNFVLPPQMRPAVGPP----------------------QPRPPFAGAR 219

Human   253 LMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPG 317
            .|.||...|.:|  |..|.|.|.....:.           |..||     .|||:       |||
  Fly   220 PMVGMGPRPPMP--PNMAARPPPLRSTDS-----------KSNLL-----MGPPM-------RPG 259

Human   318 SKEEVD-EDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVST 381
            ...::: :...:..:..|.|||.:..|    |||..........||.| .||.| |.:.
  Fly   260 MPPQLNMQQARLPNAGGQLSPPGQGPP----RPPGGFPWNPAGAPGMP-PGARP-PQNM------ 312

Human   382 EIPASEPDGPSVGR-AKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPS 445
                :.|..|:..| ..||  ||:..|:                   |..|...|.: |:.:.|
  Fly   313 ----TRPPPPTFARPPPGQ--PLQAPFN-------------------RPPFNQPPMQ-PQQQQP- 350

Human   446 LGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKN 510
                      |:..::|.....:.:.:.:..||:....:.:.:....||........:..||..:
  Fly   351 ----------PQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNS 405

Human   511 RPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATP 575
            ||  .|      ..:||::...|.....||:.       .|:.| .|.|.....|.|..|:....
  Fly   406 RP--DP------MGEPLLEDIEPPFQTSPPAG-------ESKKG-PGFKGDNDSGVDESTQEKDR 454

Human   576 RGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSG-DRSGYSSPGSPGTPGSRSRTPS---L 636
            .|...|..         |.|||.:     :|.:|.||| .|...::|.:...|.|||.:.:   |
  Fly   455 NGPNSPSS---------PVKTPTS-----TSSKPDKSGTSRPPSATPSNKSAPKSRSASKNRLLL 505

Human   637 PTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINK 701
            .||.....|||.:            :::|....|.|:||.|:|||||.:|..::||||.|:|.:|
  Fly   506 KTPEPEPVKKVPM------------NKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESK 558

Human   702 KLDLS----------------------------NVQSKCGSKDNIKHVPGGGSVQIVYKPVDL-S 737
            |:|:.                            |.:||.||.:|..|.||||..:|....:|. .
  Fly   559 KIDIKAAPRIEAKNDKYMPKGGEKKIVTTKLQWNAKSKIGSLENAAHKPGGGDKKIETLKMDFKD 623

Human   738 KVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHK--LTFR 800
            |...|.||..|:.|:||||.::::::||:.|  .|||:|||||:.|.||||.|||...|  |...
  Fly   624 KAKPKVGSTANVKHQPGGGDIKIQTQKLEIK--AQSKVGSLDNVKHKPGGGEKKIFDDKDYLKNV 686

Human   801 ENAKAKTDHGAEIVYKSPVVSG 822
            |::.|.|....:....|...||
  Fly   687 EHSVALTTPPTQSPLPSMTASG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPT	XP_005257419.1	Tubulin-binding	<673..694	CDD:278828	11/20 (55%)
		Tubulin-binding	696..725	CDD:278828	14/56 (25%)
		Tubulin-binding	727..756	CDD:278828	10/29 (34%)
		Tubulin-binding	758..788	CDD:278828	14/29 (48%)
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	14/29 (48%)
		Tubulin-binding	583..610	CDD:278828	9/26 (35%)
		Tubulin-binding	613..642	CDD:278828	10/28 (36%)
		Tubulin-binding	644..672	CDD:278828	14/29 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005553
OrthoInspector	1	1.000	-	-		otm41144
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	1	1.000	-	-		X4510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030