DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaG and CG9518

DIOPT Version :9

Sequence 1:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	170/599 - (28%)
Similarity:	267/599 - (44%)	Gaps:	88/599 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKH 111
            :|:::||.|:.|:.:.:.|::.....|||||||.....:|.:|.|..:.|....||::.:.|...
  Fly    57 YDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPSTK 121

  Fly   112 SSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQ-MRSFMAAAKPK 175
            :..|:...|...|||:.||||:.|||||:..|:..|:|.|....| ..|.:.. :|.|..:...:
  Fly   122 ACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGN-PGWDYDNVLRYFKKSEDNR 185

  Fly   176 NP-----------DMLEIPRR--YSKLTEALEEAQAQFAY--------KDWIFRRSLYNIRNGLR 219
            ||           .:|.:...  :|.|..|..||..|..|        |...|..:...||.|.|
  Fly   186 NPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFMIAQGTIRRGSR 250

  Fly   220 HSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPF-LQATSILVGIKDEENREKEFSIEVRRELI 283
            .|..:.||.|:....|..|..::.|.|:.:.|... .||...:       ...|.:.|..|||:|
  Fly   251 CSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFV-------KHGKVYRIAARREVI 308

  Fly   284 LCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLPLFVSMG-----VTGPTL 343
            :.|||..||||:|.||:|....|:|.||.....|| ||.|:.||      |.||     |..|..
  Fly   309 ISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLP-VGENMQDH------VGMGGLTFLVDKPVA 366

  Fly   344 NQNTLLNPMTL-INYLSSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGAGAID------ESALM 401
            ......||..: ..|:....||:         .:.||:....:..|.:...::|      ..|..
  Fly   367 IVQDRFNPTAVTFQYVLRERGPM---------TTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPA 422

  Fly   402 SISNFKGPAFR-------ALFPRYYN--SSQEGFVVISSCLQPKSRGSVGLLNRHMRRNPLIDPN 457
            ||::..|...:       :::...|:  ::::.:.::...|:|:|||||.|.:.:....|||:.|
  Fly   423 SINSDNGARVKKVLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINAN 487

  Fly   458 YLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDFFDNRPSDQYLECL 522
            |.....|....:...:.|:.:..:..|.....|:....:..|.     :..|.    ||.||||.
  Fly   488 YFDDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCK-----QHKFL----SDAYLECH 543

  Fly   523 MRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVVAIALR 581
            :|.:.:..:||.||..:|      :|||.:||:.||..:||:|||::|...|||.|:.|:.||.:
  Fly   544 VRTISMTIYHPCGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEK 608

  Fly   582 AA-----SWILKSE 590
            .|     .|:...|
  Fly   609 GADLIKEDWLTNPE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaG	NP_650070.1	BetA	72..588	CDD:225186	163/570 (29%)
		NADB_Rossmann	119..327	CDD:304358	74/230 (32%)
		GMC_oxred_C	435..582	CDD:282984	50/152 (33%)
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	168/589 (29%)
		NADB_Rossmann	128..351	CDD:304358	74/231 (32%)
		GMC_oxred_C	465..608	CDD:282984	50/151 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446444
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	7.940