DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaG and CG9522

DIOPT Version :9

Sequence 1:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_644677.1	Gene:	CG9522 / 32413	FlyBaseID:	FBgn0030587	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	179/606 - (29%)
Similarity:	284/606 - (46%)	Gaps:	104/606 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKH 111
            :|::|||||..|.||.:.|::|.|.||.||||||...::.::|||....|...::|.:.|.||:|
  Fly    51 YDFIIVGGGAAGCTLAARLSENPNWSVFLIEAGGVENIVHQVPLLAAHLQSTASNWGYNSTPQRH 115

  Fly   112 SSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRSFMAAAK--- 173
            :.||:.:.:..|||||.|||::::|||::..|:..|||:|....| ..||:.::..:...::
  Fly   116 ACRGMPDNKCALPRGKVLGGTSSINYMIYNRGNRRDFDAWAAAGN-PGWSYDEVLPYFLRSEHAQ 179

  Fly   174 -----------PKNPDMLEIPRRYSKLTEALEEAQAQFAYKDWIFRRSLYN-------------I 214
                       ...|..:|..|..::|..|...|..:..:.     |:.||             .
  Fly   180 LQGLEHSPYHNHSGPLSVEDVRHRTRLAHAYIRAAQEAGHP-----RTDYNGESQLGVSYVQATT 239

  Fly   215 RNGLRHSVVQQFLNPV-IHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENREKEFSIEV 278
            ..|.|||..:.::.|: ....||.:|..|.|.|:.:.     .||....|: :..::.:.|.::.
  Fly   240 LKGRRHSAFRAYIEPIRSRRHNLHILTLARVTRVLID-----AATKSAYGV-ELTHQGRSFKVKA 298

  Fly   279 RRELILCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHD---HFNLPLFVSMGVTG 340
            |:|:||.|||:.:|||||.||||....||.:|||...:|| ||..:.|   ||. |.||: ..||
  Fly   299 RKEIILSAGAFNSPQLLMLSGIGPEDNLKAIGIPLIKALP-VGKRMFDHMCHFG-PTFVT-NTTG 360

  Fly   341 PTLNQNTLLNPMTLINYLSSGSGPLGNFGVLGN----VVSYGGLGAPPYGITFFG---------- 391
            .||             :.:....|:....:||.    :.|.||:..    :||..
  Fly   361 QTL-------------FAAQLGAPVAKEFLLGRADTFLSSIGGVET----LTFIKVPSGKSPATQ 408

  Fly   392 --------AGAI---DESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLN 445
                    ||::   |.:||...:|||...:..::.......|:.|..:....:|.|.|.:.|.|
  Fly   409 PDVELIQVAGSLASDDGTALAKGANFKPEIYEKMYKNLTLRQQDHFSFLIMHFKPASVGRLWLHN 473

  Fly   446 RHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDFF 510
            |:....|.|||.|.|:..||...:..|:.|:.:....|..|:..|:....|..|.|:     :|
  Fly   474 RNPLEWPRIDPKYFSAPSDVENLLEGIKEALRISKMPAMQAIGTRLLDKPVPGCENY-----EF- 532

  Fly   511 DNRPSDQYLECLMRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVVDASVLPRPISG 569
               .||.|..|.:|.:....||...||.:|      :||:.||::.||..:||||.|::|.|.:.
  Fly   533 ---ASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTA 594

  Fly   570 NPNSVVVAIALRAASWILKSE 590
            :.|:....|..:||. :::||
  Fly   595 HTNAAAFMIGEKAAD-MIRSE 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaG	NP_650070.1	BetA	72..588	CDD:225186	165/577 (29%)
		NADB_Rossmann	119..327	CDD:304358	69/238 (29%)
		GMC_oxred_C	435..582	CDD:282984	48/152 (32%)
CG9522	NP_644677.1	PRK02106	48..612	CDD:235000	177/602 (29%)
		NADB_Rossmann	52..>83	CDD:304358	17/30 (57%)
		NADB_Rossmann	127..348	CDD:304358	69/233 (30%)
		GMC_oxred_C	463..607	CDD:282984	48/152 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446452
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	7.940