DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaG and Chdh

DIOPT Version :9

Sequence 1:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_942026.1	Gene:	Chdh / 290551	RGDID:	735166	Length:	599	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	170/604 - (28%)
Similarity:	257/604 - (42%)	Gaps:	120/604 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAG------GQFGLLSRIPLLTTFQQKGIND---W 102
            :.:::||.|:.|..|.:.|.::.|..|||:|||      |...|..:|.:.........:|   |
  Rat    46 YTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVANLCDDKYNW 110

  Fly   103 SFLSVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRS 167
            .:.:..|.    ||..|....|||:..|||::||.|::..||..|::.|. ......|.:|....
  Rat   111 YYHTEAQP----GLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWH-RQGAEGWDYAHCLP 170

  Fly   168 FMAAAK-------------------------PKNPDMLEIPRRYS-KLTEALEEAQAQ-FAYKDW 205
            :...|:                         |.:...|:..|:.. ..||.:...|.: |.:.|
  Rat   171 YFRKAQKHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGFQQEGFGWMD- 234

  Fly   206 IFRRSLYNIRNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVG---IKDE 267
                  ..|..|.|.|....:|.|.:...|||.....||.|:      ..:.|. .||   |||.
  Rat   235 ------MTIHQGKRWSTASAYLRPALSRPNLRAEVQTLVSRV------LFEGTR-AVGVEYIKDG 286

  Fly   268 ENREKEFSIEVRRELILCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLPL 332
            ::.:    ..|.||:||..||..:|||||.||:|:...|||||||....||.||.||.||  |.:
  Rat   287 QSHK----AYVSREVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPGVGQNLQDH--LEI 345

  Fly   333 FVSMGVTGP-TLN--QNTLLNPMTLINYL--SSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGA 392
            ::....|.| ||:  |..|......:.:|  .:|.|...:....|.:.|..|:..|.....|..:
  Rat   346 YIQHACTQPITLHSAQKPLRKVCIGLEWLWRFTGDGATAHLETGGFIRSRPGVPHPDIQFHFLPS 410

  Fly   393 GAIDESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLNRHMRRNPLIDPN 457
            ..||..        :.|           :.||.:.|....::..|.|.:.|.:.:.:.:|:|:||
  Rat   411 QVIDHG--------RKP-----------TQQEAYQVHVGTMRATSVGWLKLRSTNPQDHPMINPN 456

  Fly   458 YLSSEEDVACTISAIRSAVELVNSTAFA-----ALHPRIHWPRVQECSNFGPFERDFFDNRPSDQ 517
            |||:|.||......::...|:....|||     .|.|..|   ||                 ||:
  Rat   457 YLSTETDVEDFRQCVKLTREIFAQEAFAPFRGKELQPGSH---VQ-----------------SDK 501

  Fly   518 YLECLMRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVV 576
            .::..:|.....::||..||.:|      :|||.|.|:.||.|:||:|||::|..:|||.|:..:
  Rat   502 EIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTI 566

  Fly   577 AIALRAASWILKSELQAGD 595
            .||.:||. ::|.....||
  Rat   567 MIAEKAAD-VIKGCPALGD 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaG	NP_650070.1	BetA	72..588	CDD:225186	160/570 (28%)
		NADB_Rossmann	119..327	CDD:304358	71/237 (30%)
		GMC_oxred_C	435..582	CDD:282984	50/157 (32%)
Chdh	NP_942026.1	PRK02106	45..591	CDD:235000	170/604 (28%)
		NADB_Rossmann	49..>151	CDD:304358	33/105 (31%)
		GMC_oxred_N	121..344	CDD:279121	73/243 (30%)
		GMC_oxred_C	435..572	CDD:282984	50/156 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.710