DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaG and CG45065

DIOPT Version :9

Sequence 1:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001285251.1	Gene:	CG45065 / 19835504	FlyBaseID:	FBgn0266435	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	175/603 - (29%)
Similarity:	280/603 - (46%)	Gaps:	109/603 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKH 111
            :|:|::|||:.|:.:.:.|::..|.:|||:||||....:|.:|.|..:.|....||.:.:.|.
  Fly    44 YDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDETEISDVPALAGYLQLTELDWKYQTTPS-- 106

  Fly   112 SSRGLIERR---QCL-PRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSW-AQMRSFMAA 171
            |:|...:..   :|. ||||.||||:.||.|::..|...|::.|....| ..|.: :.::.|:.:
  Fly   107 STRQYCQAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYNHWASLGN-PGWDYDSMLKYFLKS 170

  Fly   172 AKPKNPDMLEIPRR-------------YSKLTEALEEAQAQFAYKD----------WIFRRSLYN 213
            ...:||.:.:.|..             .:.|:.|..:|..:..|::          ::..:|  .
  Fly   171 EDVRNPYLAKTPYHETGGYLTVQEAPWRTPLSIAFLQAGIEMGYENRDINGAQQTGFMLTQS--T 233

  Fly   214 IRNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSIL-------VGIKDEENRE 271
            ||.|.|.|..:.|:.||....|..:|..|             :||.||       :|::......
  Fly   234 IRRGARCSTGKAFIRPVRQRKNFDVLLHA-------------EATRILFDKQKRAIGVEYMRGGR 285

  Fly   272 KEFSIEVRRELILCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLP--LFV 334
            |.. :.||||:|..|||..||:|||.||:|....|::..||....|| ||:|:.||..|.  .||
  Fly   286 KNV-VFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVISDLP-VGNNMQDHVGLGGLTFV 348

  Fly   335 SMGVTGP-TLNQNTLLNPMTLINYLSSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGAGAIDES 398
               |..| |:.:|........:.|:....||:...||              .|:.|......|.|
  Fly   349 ---VDAPLTVTRNRFQTIPVSMEYILRERGPMTFSGV--------------EGVAFLNTKYQDPS 396

  Fly   399 ----------ALMSISNFKGPAFRALF---PRYYNS------SQEGFVVISSCLQPKSRGSVGLL 444
                      ...||::..|...|.:.   ..:||:      ..|.:.::...|:|||.|.|.|.
  Fly   397 VDWPDVQFHFCPSSINSDGGEQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTGWVRLN 461

  Fly   445 NRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDF 509
            :|:.:..|.|.|||.:.:||:...:..|:.|:.:.|:.||.....|:|...:..|.:. ||:
  Fly   462 SRNPQHQPKIIPNYFAHQEDIDVLVEGIKLAINVSNTQAFQRFGSRLHNIPLPGCRHL-PFQ--- 522

  Fly   510 FDNRPSDQYLECLMRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVVDASVLPRPIS 568
                 |::|..|.::......:||.|||.:|      :|||.:||:.|||.|||||||::|..::
  Fly   523 -----SNEYWACCIKEFTFTIYHPAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVN 582

  Fly   569 GNPNSVVVAIALRAASWI 586
            ||||:.|:||..:|:..|
  Fly   583 GNPNAPVIAIGEKASDLI 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaG	NP_650070.1	BetA	72..588	CDD:225186	167/578 (29%)
		NADB_Rossmann	119..327	CDD:304358	67/242 (28%)
		GMC_oxred_C	435..582	CDD:282984	56/152 (37%)
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	175/603 (29%)
		NADB_Rossmann	117..339	CDD:304358	67/239 (28%)
		GMC_oxred_C	452..596	CDD:282984	56/152 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446447
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	7	6.940