DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and SLC5A6

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens

Alignment Length:	602	Identity:	203/602 - (33%)
Similarity:	324/602 - (53%)	Gaps:	74/602 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LQRFAWPDYVAFVSMFLLCIGIGIYF---GFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGI 72
            :..|:..|||.||.:.:|.:.||:|.   |:...:|.|  .::..|||..:|:|.||:|:|.|.:
Human    21 MSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGE--LLMADRKMGCLPVALSLLATFQSAV 83

  Fly    73 TLLGLPTEVYSYGIQYLYVS-CGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSV 136
            .:||:|:|:|.:|.||.::. |..:|:.:...:| :|||:.|::||.|||||:||::.:|:.|:|
Human    84 AILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIF-IPVFYRLHLTSAYEYLELRFNKTVRVCGTV 147

  Fly   137 MFAIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISM-L 200
            .|....|.|:.:|:|.|:||.|.|||..:......:.|:|..||:|||||||:||||.|.:.| |
Human   148 TFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFL 212

  Fly   201 GALCLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQN 265
            |.|.:: |.|:..:||.|.|...|....|:...:|..||.||||||.|.|||:........|:|.
Human   213 GQLAVI-IVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQA 276

  Fly   266 MIQRYLSLPSLGDARKALCI------------FCVGVLILMALCGYNGLLIYATYQNCDPLTTKL 318
            .:|||||    ....||..:            .|||.||        ||:::|.||.. |::.:.
Human   277 QVQRYLS----SRTEKAAVLSCYAVFPFQQVSLCVGCLI--------GLVMFAYYQEY-PMSIQQ 328

  Fly   319 AKAR-DQLLPLFVMKTLGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSS 382
            |:|. ||.:..|||..|..|||:.|||||.:||.:||::|:..||::.|.:||.::|:..:...:
Human   329 AQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEA 393

  Fly   383 SAINWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSAL 447
            .|| .:.|.:..|.|:||:.:.|:...||.|||..:|:..:..|||.|:|.:|:|.|..|...|:
Human   394 RAI-MLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAV 457

  Fly   448 VGGVMGVIAMSWVSLNAQWAIASGAITYKTKPLNVEQCDYSFNVTTSLANTTHLGASAEDIFPL- 511
            ||.:.|::...|:.:.:  .:.|...:....|.|    ..||::.|:|.     .|:...:.||
Human   458 VGLLAGLVMAFWIGIGS--IVTSMGSSMPPSPSN----GSSFSLPTNLT-----VATVTTLMPLT 511

  Fly   512 -----------YRISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFF------ 559
                       |.:||:||:...::..|.|.|:.:.:.|:.....::|..:.|.:.|..
Human   512 TFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLS 576

  Fly   560 --------AFGSEKHMD 568
                    ::|.: |:|
Human   577 CQKRLHCRSYGQD-HLD 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	195/549 (36%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	196/554 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820