Protein Alignment bumpel and Slc5a7

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_445973.2
• Gene: Slc5a7 / 85426
• RGDID: 69270
• Length: 580
• Species: Rattus norvegicus
• Alignment Length: 471
• Identity: 110/471 - (23%)
• Similarity: 195/471 - (41%)
• Gaps: 72/471 - (15%)

  Fly    20 VAFVSMFLLCIGIGIYFGFMNKSVS-----EDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPT 79
            ||.:..:||...:||:..:..|:..     .:..::|||.:.::...|::.|::|.|..:.|...
  Rat     9 VAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAE 73

  Fly    80 EVYSYGIQYLYVSCGV------IGMG---VVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGS 135
            .||..|       ||:      ||..   ::.|:|:..........:..:..:..:.:|:   |.
  Rat    74 AVYGPG-------CGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRM---GG 128

  Fly   136 VMF--AIMNVAYLPIVIYVPAL--AFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQA 196
            ::|  |:|...:....|: .||  ..:.:..:.|:....:..:|.:.||.:|||.:|.:|||||.
  Rat   129 LLFIPALMGEMFWAAAIF-SALGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQL 192

  Fly   197 --------ISMLGALCLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFW-----CL 248
                    ||:..||...|:   .|||...|       ..:.::|.|....::....|     .|
  Rat   193 FCIFIGLWISVPFALSHPAV---TDIGFTAV-------HAKYQSPWLGTIESIEVYTWLDNFLLL 247

  Fly   249 FFGGI---VYWTQTNAVSQNMIQRYLS-LPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQ 309
            ..|||   .|:.:..:.|.....:.|| |.:.|....||...|:|.  :.|...:|    ...|.
  Rat   248 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGA--IGASTDWN----QTAYG 306

  Fly   310 NCDPLTTKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAA-LSSLSTCLNSMSAVVLEDFVK 373
            ..||.|.:.|   |.:||: |::.|  .|.....|..|..||| :||..:.:.|.|::...:..:
  Rat   307 FPDPKTKEEA---DMILPI-VLQYL--CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQ 365

  Fly   374 PYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFL 438
            ...::..|...|.|:||:.|...|.....:..:.:.:..:..|:..|..|.   :|......||:
  Rat   366 LSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYII---IFPQLLCVLFI 427

  Fly   439 PWINGNSALVGGVMGV 454
            ...|...|:.|.:.|:
  Rat   428 KGTNTYGAVAGYIFGL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	110/471 (23%)
Slc5a7	NP_445973.2	SLC5sbd_CHT	8..495	CDD:271368	110/471 (23%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000269|PubMed:17092608	502..580
		Dileucine-like motif. /evidence=ECO:0000250|UniProtKB:Q9GZV3	527..532