DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and SLC5A3

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_008864.4	Gene:	SLC5A3 / 6526	HGNCID:	11038	Length:	718	Species:	Homo sapiens

Alignment Length:	563	Identity:	128/563 - (22%)
Similarity:	235/563 - (41%)	Gaps:	89/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VAFVSM-FLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVYS 83
            :|.|:: |:|.:.||.:..:.:...:...|.|.||.|..:.|..||..|.:.....:||.....:
Human    10 IAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAA 74

  Fly    84 YGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-AYL 146
            .|..........:.:..::|..::|::....:.:..|||..|| ..|:::|.:.:..|:.: ..|
Human    75 SGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKL 139

  Fly   147 PIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISM-LGALCLVAIKG 210
            .:.:|..||...:..|..::....::..:....|..|||.||::||.:||:.| :|||.|:.| .
Human   140 SVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMII-S 203

  Fly   211 TRDIGGAGVVLERAWSSDRLEAPDLSI--------------------------DPTVRHTFWCLF 249
            ..:|||...|..|.    .|.:||::.                          :||.....|..|
Human   204 IMEIGGFEEVKRRY----MLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGF 264

  Fly   250 FGG-----IVYWTQTNAVSQNMIQRYLSLPSLGDAR---------KALCIFCVGVLILMALCGYN 300
            ..|     :.||    ...|.::||.|:..::..|:         |.|.:|.:.|..:::...:.
Human   265 ILGQTPASVWYW----CADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFT 325

  Fly   301 GLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGELP-GMTGLFIAGVFSAALSSLSTCLNSMS 364
            ..:.....::|..:....|...:...|..|||.   :| |:.||.:|.:.:|.:|.|.:..||.|
Human   326 DDIACINPEHCMLVCGSRAGCSNIAYPRLVMKL---VPVGLRGLMMAVMIAALMSDLDSIFNSAS 387

  Fly   365 AVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLV-YVVEHMGTVLQLTMSLEAITN--- 425
            .:...|..| .::|..||..:..:.|:.|..:.|:.:..| .:||..|.  |:.:.::.:.:
Human   388 TIFTLDVYK-LIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGG--QMYLYIQEVADYLT 449

  Fly   426 GPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNAQWAIASGAITYKTKPLNVEQCDYSFN 490
            .|:..:|.:.:|....|...|..||:.|.:      |.|...|.  |..|:     ..:||...|
Human   450 PPVAALFLLAIFWKRCNEQGAFYGGMAGFV------LGAVRLIL--AFAYR-----APECDQPDN 501

  Fly   491 VTTSLANTTHLGASAEDIFPLYRISYMWYTTFGASITIFVALL 533
            ....:          :||..:|..:.:::.|  ..||:.|:||
Human   502 RPGFI----------KDIHYMYVATGLFWVT--GLITVIVSLL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	128/563 (23%)
SLC5A3	NP_008864.4	SLC5sbd_SMIT	9..718	CDD:271382	128/563 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740