Protein Alignment bumpel and SLC5A2

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 118/509 - (23%)
• Similarity: 212/509 - (41%)
• Gaps: 77/509 - (15%)

  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82
            |.:...:.|||.||:|::........:...|.|.||.|:..|:..||.||.:.....:||.....
Human    25 DILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGA 89

  Fly    83 SYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-AY 145
            :.|:.........:.:.:::|..:.||:....:.:..:||..|| .||:|||.||:...:.: ..
Human    90 ASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTK 154

  Fly   146 LPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKG 210
            :.:.::..|:...|..|..::.....:..|.:.||..|||.|:::||.||...:||..|::....
Human   155 ISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYA 219

  Fly   211 TRDIGGAGVVLERAWSSDRLEAPDLSI--DPTV------------------RHTF-----WCLFF 250
            ..::||...:.::...:    |..|::  ||.|                  ||..     |....
Human   220 FHEVGGYSGLFDKYLGA----ATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALL 280

  Fly   251 GGIV-----YWTQTNAVSQNMIQRYLSLPSLGDARKALCIFC----VGVLILMALCGYNGLLIY- 305
            .|:.     ||..    .|.::||.|:..||... ||.||.|    :..:.||.:.|....::|
Human   281 LGLTIVSGWYWCS----DQVIVQRCLAGKSLTHI-KAGCILCGYLKLTPMFLMVMPGMISRILYP 340

  Fly   306 ---------------ATYQNCDPLTTKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSS 355
                           .|...|..:.          .|..|:|.:..  |:.||.:|.:.:|.:||
Human   341 DEVACVVPEVCRRVCGTEVGCSNIA----------YPRLVVKLMPN--GLRGLMLAVMLAALMSS 393

  Fly   356 LSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVE--HMGTVLQLTM 418
            |::..||.|.:...| :...::.......:..:.||.||.:.|:.|..:.||:  ..|.:.....
Human   394 LASIFNSSSTLFTMD-IYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQ 457

  Fly   419 SLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNAQWAIASGA 472
            ::.:....|:..:|.:.||:|.:|...|. .|::|.:.|....|..:::..||:
Human   458 AVSSYLAPPVSAVFVLALFVPRVNEQGAF-WGLIGGLLMGLARLIPEFSFGSGS 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	118/509 (23%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	118/509 (23%)