Protein Alignment bumpel and SLC5A1

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 112/486 - (23%)
• Similarity: 208/486 - (42%)
• Gaps: 52/486 - (10%)

  Fly    10 ELQRFAWPDYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITL 74
            ||.|.| .|....|..|::.:.:|::..|.....:...:.|.||.|:..||..||.||.:.....
Human    21 ELIRNA-ADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHF 84

  Fly    75 LGLPTEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMF 138
            :||.....:.||.........:.:.||:|..::|::....:.:..|||..|| .:|:::|.|::.
Human    85 VGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLS 149

  Fly   139 AIMNV-AYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISML-G 201
            .::.: ..:...|:..|:..|...|:.::....::..|...||..|||.||::||.:|.:.|| |
Human   150 LLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVG 214

  Fly   202 ALCLVAIKGTRDIGGAGVVLERAWS------SD------------RLEAPDLSIDPTVRHTFWCL 248
            :|.|... ...::||....:|:...      ||            |.::..:..||......|..
Human   215 SLILTGF-AFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPG 278

  Fly   249 FFGG-----IVYWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVL-----ILMALCGYNGLL 303
            |..|     :.||    ...|.::||.||..::... |..||.| |.|     .:|.:.|....:
Human   279 FIFGMSILTLWYW----CTDQVIVQRCLSAKNMSHV-KGGCILC-GYLKLMPMFIMVMPGMISRI 337

  Fly   304 IY------ATYQNCDPLTTKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSSLSTCLNS 362
            :|      .....|:..........:...|..|::.:..  |:.||.::.:.::.:|||::..||
Human   338 LYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPN--GLRGLMLSVMLASLMSSLTSIFNS 400

  Fly   363 MSAVVLEDFVKPYVKKPLSSSAI---NWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEAIT 424
            .|.:...| :...|:|..|...:   ..:..||::|:.:..|.:|...: .|.:.....|:.:..
Human   401 ASTLFTMD-IYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQ-SGQLFDYIQSITSYL 463

  Fly   425 NGPLFGIFTIGLFLPWINGNSALVGGVMGVI 455
            ..|:..:|.:.:|...:|...|..|.::|::
Human   464 GPPIAAVFLLAIFWKRVNEPGAFWGLILGLL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	108/479 (23%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	108/479 (23%)