DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and Slc5a4a

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_573447.2	Gene:	Slc5a4a / 64452	MGIID:	1927848	Length:	656	Species:	Mus musculus

Alignment Length:	541	Identity:	124/541 - (22%)
Similarity:	228/541 - (42%)	Gaps:	95/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82
            |....|..|::.:.:|::........:...:.|.||.|...|:..||.||.:.....:||.....
Mouse    28 DISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGA 92

  Fly    83 SYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFA-IMNVAY 145
            :.||...........:.:|:|..::|::....:.:..|||:.|| .:||::|.|::|. |..:..
Mouse    93 ASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILT 157

  Fly   146 LPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKG 210
            :...|:..|:......|:.::....|:..|...:|..|||.:|::||.|||:.||....::.:..
Mouse   158 ISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFA 222

  Fly   211 TRDIGGAGVVLERAWSS--DRLEAPDLSID-------PTVRHTF---------W-CLFFG----G 252
            ..::||.....|:..::  ..:|..:|:|:       |...|.|         | ...||    .
Mouse   223 FVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITA 287

  Fly   253 IVYWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVLIL-----MALCGYNGLLIYATYQNCD 312
            :.||    .::|.::||.|...:|... ||.||.| |.|.|     |.:.|....::|.....|
Mouse   288 LWYW----CINQVIVQRCLCGKNLSHV-KAACILC-GYLKLLPLFFMVMPGMISRILYTDMVAC- 345

  Fly   313 PLTTKLAK-------ARDQLLPLFVMKTLGELP-GMTGLFIAGVFSAALSSLSTCLNSMSAVVLE 369
            .:.::..|       ..:...|:.|:|.   :| |:.||.::.:.::.:|||::..||.|.:...
Mouse   346 VVPSECVKHCGVDVGCTNYAYPMLVLKL---MPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTI 407

  Fly   370 D-FVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVE--HMGTVLQLTMSLEAITNGPLFGI 431
            | :.|  ::|..|...:....||.|..:.|..:..|.:||  ..|.::..|.::.:....|:..:
Mouse   408 DLYTK--IRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAV 470

  Fly   432 FTIGLFLPWINGNSA----LVGGVMGVIAMSWVSLNAQWAIASGA-------------------- 472
            |.:.:|....|...|    :||.|||:|.|.     |:::..:|:
Mouse   471 FLVAVFCKRANEQGAFWGLMVGLVMGLIRMI-----AEFSYGTGSCLAPSSCPKIICGVHYLYFA 530

  Fly   473 -------------ITYKTKPL 480
                         ::|.|||:
Mouse   531 IILFFVCILVILGVSYLTKPI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	124/541 (23%)
Slc5a4a	NP_573447.2	SLC5-6-like_sbd	27..656	CDD:294310	124/541 (23%)
Slc5a4a	NP_573447.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740