DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and slc5a6a

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001020700.2	Gene:	slc5a6a / 563356	ZFINID:	ZDB-GENE-041001-177	Length:	625	Species:	Danio rerio

Alignment Length:	579	Identity:	190/579 - (32%)
Similarity:	317/579 - (54%)	Gaps:	22/579 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FAWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGL 77
            |:..|||.||.:.:...|||:|:.|. .:..:..:::|..|.|..:|::.||:|:|.|.:.:||.
Zfish     9 FSTVDYVIFVVLLVASAGIGLYYAFSGGRQRTTQEFLLADRSMRCLPVSLSLLATFQSAVAILGA 73

  Fly    78 PTEVYSYGIQYLYVSCG-VIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIM 141
            |:|:|:||.||.::.|. .:|:.:...:| :|||:.|.::|.|||||:||.:.:|:.|:|.|...
Zfish    74 PSEIYTYGTQYWFLGCSYFLGLLIPAHIF-IPVFYRLRLSSAYEYLELRFSKSVRICGTVTFIFQ 137

  Fly   142 NVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLV 206
            .|.|:.:|:|.||||.|.|||..:......:.::|..||:|||||||:||||.|.|.|......|
Zfish   138 MVIYMGVVLYAPALALNAVTGFDLWGAVLAMGLVCTLYTALGGLKAVIWTDVFQTIVMFAGQLAV 202

  Fly   207 AIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYL 271
            .:.||...||...|..:|.:..|:...||:.||..|||||.|..||:........|:|..:||||
Zfish   203 IVVGTHQAGGIAEVWRKAQNGSRIAGLDLNPDPLERHTFWTLGVGGVFLMLALYGVNQAQVQRYL 267

  Fly   272 SLPSLGDARKALCIFCVGVL----ILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMK 332
            |    ....|...:.|..|.    :::.|....||::||.|....||........||::...||.
Zfish   268 S----SRTEKEAIMSCYAVFPCQQVVLTLGCLMGLVMYARYGEESPLDQGYVTTNDQMVLYLVMD 328

  Fly   333 TLGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVG 397
            .|.:|||:.|||:|.:||.|||::|:..||::.|.:||.:||:| ..::.:....:.:::.:..|
Zfish   329 VLRDLPGLPGLFVACLFSGALSTISSAFNSLATVTMEDLIKPHV-PAMTEARATLLSKMLALAYG 392

  Fly   398 VLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSL 462
            ::|:.:.|:...||:|||..:|:..:..|||.|:|.:|:|.||.|...||||...|::...|:.:
Zfish   393 LVCLAMAYIASLMGSVLQAALSIFGMVGGPLLGLFCLGMFFPWANSTGALVGLASGLVMAFWIGI 457

  Fly   463 N---AQWAIASGAITYKTKPLNVEQCDYSFNVTTSLANT-THLGASAEDIFPLYRISYMWYTTFG 523
            .   ::.::::..:...|...:|.      |:||::..| |........:..||.:|||||:...
Zfish   458 GSFVSRMSLSALPVINATIIPDVG------NMTTAVMTTLTTTKPRPSGVQALYSLSYMWYSAHN 516

  Fly   524 ASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKHMDAFRPDIPLQHKLRN 582
            ::..:.|.|:.:|:.|......::|..:.|.:.....|..:::.:......||:.|.::
Zfish   517 SATVVVVGLVVSFLTGPWKEKDLNPGTVYPVLGNLLFFLPQRYREKLCCVTPLEDKSKD 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	181/529 (34%)
slc5a6a	NP_001020700.2	SLC5-6-like_sbd	9..532	CDD:294310	183/534 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820