DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and slc5a5

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	568	Identity:	188/568 - (33%)
Similarity:	301/568 - (52%)	Gaps:	46/568 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FAWPDYVAFVSMFLLCIGIGIYFGFMNKSVSE---DDYMLGGRKMLVIPIAFSLVASFVSGITLL 75
            |...||..|.:|..:.:|||: |..:.|:...   |.:..|||....:|:..||.|||:|.:.:|
Zfish    11 FCLVDYAVFAAMLGVSVGIGL-FQSLRKTPGRSKVDSFFTGGRGFSAVPVGLSLCASFMSAVQVL 74

  Fly    76 GLPTEVYSYGIQYLYVSCGVIGMGVVM-GVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFA 139
            |:|:|.|.||.::||:..|. |:..:| .|.::|||:.|.|||:.:||.:||.|.::|.||:.|.
Zfish    75 GVPSETYLYGFKFLYMCLGQ-GLNSLMTAVLFVPVFYRLKITSSSQYLGMRFGRGMQLLGSLQFI 138

  Fly   140 IMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALC 204
            :..:.|..|||:.||:..||.||:.:........:||.|||::||:|||:||||.|.:.||....
Zfish   139 VATLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICTFYTTVGGMKAVIWTDVFQIVVMLSGFI 203

  Fly   205 LVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQR 269
            .|.|:||...||...|||.|.:..|:...|.:|||..|::||....||.:.|......:|..:||
Zfish   204 AVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWSFTVGGTMVWLSMYGANQAQVQR 268

  Fly   270 YLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTL 334
            |:|..:...|:.||.:..||:.::::.....|::::|.|.|||||......|.||.:|..|:...
Zfish   269 YISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCDPLKIGRISAPDQYMPYLVLDIF 333

  Fly   335 GELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYV------KKPLSSSAINWIMRLVV 393
            ...||..|||:|..:|..||::||.:|:|:||.:||.:||::      |:.:.|.|::     :.
Zfish   334 RNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPWLITISQRKQLMLSRALS-----LF 393

  Fly   394 VGVGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMS 458
            .|:|.:.:..:..:...| |||.:.::..:.||||.|.|.:|:|:|..|......|..:|.....
Zfish   394 YGLGCITMAALSSLLDWG-VLQGSFTVMGVVNGPLLGAFALGMFVPATNKPGVFSGVAVGFCLSL 457

  Fly   459 WVSLNAQWAIASGAITYKTK-------PLNVEQC---DYSFNVTTS-LANTTHLGASAEDIFPLY 512
            |        :|.|:..|...       |.:..||   :.:.|.|.| ||::..|..|.::|   |
Zfish   458 W--------LAVGSTIYPPSPQIMGVLPTSAGQCLTTNATLNTTASVLASSVPLDYSFQNI---Y 511

  Fly   513 RISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLL------TPC 554
            .|||:::.....|..:.|.::.:::.|....:.:.|.||      .||
Zfish   512 SISYLYFGALSTSAVVLVGVVVSYITGPTKKDSISPGLLRWNLEQKPC 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	181/540 (34%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	183/553 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950