DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001178916.1	Gene:	Slc5a8 / 500820	RGDID:	1564146	Length:	611	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	209/575 - (36%)
Similarity:	316/575 - (54%)	Gaps:	36/575 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPT 79
            | |||.|..|.|:...||||:.|. ....:..|:::|||.|..:|:|.||.|||:|.:|:||.|.
  Rat    13 W-DYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPA 76

  Fly    80 EVYS-------YGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVM 137
            |||.       :|:.|.:|.       |:....:||||:.|.|||||||||:||:|.:||.|:|:
  Rat    77 EVYRFGAIFSIFGVTYFFVV-------VISAEVFLPVFYRLGITSTYEYLELRFNRFIRLCGTVL 134

  Fly   138 FAIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGA 202
            |.:..:.|..||||.||||.|||||..:........::|.||.:||||||||||||.|...|:..
  Rat   135 FIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAG 199

  Fly   203 LCLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMI 267
            ...|.|:.:...||...:|..|.:..||...:.:.:|..|||||.:..||...||....|:|:.:
  Rat   200 FASVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTIYGVNQSQV 264

  Fly   268 QRYLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMK 332
            |||:|..|...|:.:|.:..||:.:::....:.||.:|:.|.:|||.|:|.....|||:|..|:.
  Rat   265 QRYISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVDQLMPYLVLD 329

  Fly   333 TLGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVG 397
            .|...||:.|||:|..:|..||::|:.:|:::||.:||.:||..|. ||..:::||.:.:.|..|
  Rat   330 ILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKS-LSEKSLSWISQGMSVLYG 393

  Fly   398 VLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSL 462
            .||:.:..|...||.:||..:|:..:..|||.|:|::|:.:|:.|...|..|.:.|.....||.:
  Rat   394 ALCIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLAGFAVSLWVGI 458

  Fly   463 NAQWAIASGAITYKTKPLNVEQ--CDYSFNVTTSLANT-THLGASAEDIFPL---------YRIS 515
            .||   ....:..:|.||::|.  |:.:.|.|..::.| .....||..|..:         |.:|
  Rat   459 GAQ---LYPPLPERTLPLSLETHGCNSTHNGTDWMSTTEMPFSTSAFQIHDVERSALMDNWYSLS 520

  Fly   516 YMWYTTFGASITIFVALLGTFVFGKNNPNKVDP-VLLT--PCIRKFFAFGSEKHM 567
            |::::|.|...|:.|.:|.:...|....| :|| .|||  ..:..|..|..:.|:
  Rat   521 YLYFSTIGTLTTLLVGILISLATGGRKQN-LDPRFLLTKQDFLSNFDVFKKKTHV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	198/539 (37%)
Slc5a8	NP_001178916.1	SLC5sbd_SMCT1	7..549	CDD:271402	200/547 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340267
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850