DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and slc5a12

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	583	Identity:	206/583 - (35%)
Similarity:	323/583 - (55%)	Gaps:	41/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EVLGELQRFAWPDYVAFVSMFLLCIGIGIYFGF--MNKSVSEDDYMLGGRKMLVIPIAFSLVASF 68
            |.:|   ||...|||.|..:|::..|||::|..  .||:.|: ::::|||:|...|:|.||.|||
Zfish     2 ETVG---RFQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSK-EFLVGGRQMSCGPVALSLTASF 62

  Fly    69 VSGITLLGLPTEVYSYGIQYLYVSCGVIGMGVVMGVF-----YLPVFHDLNITSTYEYLEVRFDR 128
            :|.:|::|.|.:||.:|..|:     :.|:.....||     :||||:...|||||||||:||.:
Zfish    63 MSAVTVIGAPADVYRFGASYV-----IFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCK 122

  Fly   129 RLRLYGSVMFAIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDV 193
            .:|:..::::.|..:.|..:|:|.||||.|||||..:........|:|.||.:|||||||||||.
Zfish   123 LVRVAATLIYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDA 187

  Fly   194 VQAISMLGALCLVAIKGTRDIGGAGVVLERAWSSD----RLEAPDLSIDPTVRHTFWCLFFGGIV 254
            .|.:.|:.....|.|:|:...||    :|..||:.    ||:..|..:.|..|||||.|..||..
Zfish   188 FQMVVMVVGFLTVLIQGSSRAGG----IENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTF 248

  Fly   255 YWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLA 319
            .|.....|:|:.|||.:|..:.|.||.||.:..:|:.|::.....:||::|:.|.:|||.::.|.
Zfish   249 TWLGIYGVNQSTIQRCISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLI 313

  Fly   320 KARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSSSA 384
            .|.|||:|.|||:.||..||:.|||:|..||..||:::..:|:::.|:.||||.... ..||:.|
Zfish   314 SAPDQLMPYFVMEILGAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCF-PDLSNRA 377

  Fly   385 INWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVG 449
            .:||.:.:.|..||.|..:.....:||.::|..:|:..:..||:.|:|::|:..|:.|...|:.|
Zfish   378 ASWISKALCVAFGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGG 442

  Fly   450 GVMGVIAMSWVSLNAQWAIASGAITYKTKPLNVEQCDYSFNVTTSL-----ANTTHLGASAE--- 506
            .::|:....||.:.|....|....|:..: ||...|    |:|.:.     |..|.|.:...
Zfish   443 LIVGISLSFWVGVGAFIYPAPSNNTHALE-LNTAGC----NITAAAFEPTSATVTQLTSDRNWLA 502

  Fly   507 DIFPLYRISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKHMDA 569
            |.:  |.:||::|:..|...|:...||.|.:.|..:|..:.|. :|..:::...|.:||..:|
Zfish   503 DSW--YSMSYLYYSAVGFIGTVAAGLLITLLTGPMDPKLLKPG-MTRSVKEVMCFCTEKFTEA 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	194/538 (36%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	197/549 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950