DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001102058.1	Gene:	Slc5a12 / 362188	RGDID:	1311652	Length:	619	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	202/572 - (35%)
Similarity:	315/572 - (55%)	Gaps:	46/572 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLP 78
            || |||.|.::|::..|||::|... .|..:..::::|||:|...|:|.||.|||:|.:|:||.|
  Rat     8 AW-DYVVFAALFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFAPVALSLTASFMSAVTVLGTP 71

  Fly    79 TEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNV 143
            .|||.:|..:|........:.......:||||:...||||||||::||::.:|...::::.:..:
  Rat    72 AEVYRFGASFLIFLISYAFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYILQTI 136

  Fly   144 AYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAI 208
            .|..:|:|.||||.|||||..:........|:|.||.||||||||||||..|.:.|:.....|.|
  Rat   137 LYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLI 201

  Fly   209 KGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSL 273
            :|:..:||...|||:|.:..||:..|..:||..|||||.:..||...|.....|:|:.|||.:|.
  Rat   202 QGSNHVGGFDNVLEQARNGSRLDIVDFDVDPLRRHTFWTIAVGGTFTWLGIYGVNQSTIQRCISC 266

  Fly   274 PSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGELP 338
            .:...|:.||....:|:.|::....:.||::||.|::|||.|:....|.|||:|.|||:....:|
  Rat   267 KTEKHAKLALYFNLLGLWIIVVCAVFCGLIMYAYYKDCDPWTSGAILAPDQLMPYFVMEIFATMP 331

  Fly   339 GMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVK---PYVKKPLSSSAINWIMRLVVVGVGVLC 400
            |:.|||:|..||..||:::..:|:::.|..|||||   |::...||:    ||.:.:.:..|::|
  Rat   332 GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDTLST----WISKGLCLLFGIIC 392

  Fly   401 VCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNAQ 465
            ..:..:...||:|:|..:|:..:..||:.|:||:||..|::|...||.|.:.|:....||.:
  Rat   393 TSMAVLASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSFWVGI--- 454

  Fly   466 WAIASGAITY-----KT--KPLNVEQCDYSFNVTTS---------LANTTHLGASAEDIFPLYRI 514
                 ||..|     ||  .||:.|.|......||.         ||:|            .|.:
  Rat   455 -----GAFVYPAPDSKTLPLPLSTEFCVQQNKTTTEAYQLSSRPVLADT------------WYSL 502

  Fly   515 SYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKH 566
            ||::::..|....|...::.:|:.|:.....|||:|:.| :...|.|.|:|:
  Rat   503 SYLYFSAVGCLGCIAAGIIISFLTGRQRGKDVDPLLIRP-VCNLFCFWSKKY 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	189/539 (35%)
Slc5a12	NP_001102058.1	SLC5sbd_SMCT2	3..527	CDD:212089	192/543 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340297
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850