DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and SLC5A11

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	233/594 - (39%)
Similarity:	341/594 - (57%)	Gaps:	41/594 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ELQRFAWPDYVAFVSMFLLCIGIGIYFGFMNKSV-----------------------SE--DDYM 49
            |..||...||..|:.|.:|....|||||.:.||.                       ||  .:|:
  Fly    10 ENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYL 74

  Fly    50 LGGRKMLVIPIAFSLVASFVSGITLLGLPTEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLN 114
            ||.|.:.|.|:|.||:||::||:|:||..:|:|:||.||.:::..::..|:.:...|:|||..|.
  Fly    75 LGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQ 139

  Fly   115 ITSTYEYLEVRFDRRLRLYGSVMFAIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFY 179
            :.|:|||||:||...:|...|.||.:..:.:||.::||||:|.|||:||.:|.|..::.::||||
  Fly   140 VGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFY 204

  Fly   180 TSLGGLKAVVWTDVVQAISMLGALCLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHT 244
            |.:||:||||.||..|.:.|..::..|||..|....|..|:.:.|....||...:.:..|.||||
  Fly   205 TFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHT 269

  Fly   245 FWCLFFGGIVYWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQ 309
            .|.:..||..|||..|||:|.|:|||:|||||..||.::.||.:||...:::|.|.|||||..|:
  Fly   270 VWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYK 334

  Fly   310 NCDPLTTKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKP 374
            :||||:..|....||||||||::::|.:.||:||||||:|.|||||||..|||.|.|:|||.|:.
  Fly   335 DCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRG 399

  Fly   375 YVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLP 439
            ..|...|..|...:::..|:.:|.:.:.||:|:|.:..:|.:..|:.||..|..||:||:|:.:|
  Fly   400 CFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVP 464

  Fly   440 WINGNSALVGGVMGVIAMSWVSLNAQWAIASGAITYKTKPLNVEQCDYSFNVTTSLANTT---HL 501
            |.|.....|||:...:...|:|...|:.||:|.:..:..|::||.|         :.|.|   ::
  Fly   465 WANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGC---------VGNVTLRENI 520

  Fly   502 GASAEDIFPLYRISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFA----FG 562
            ....|.:|||||:||.|....|.:..|.|..|.:.|....|...:||.|::|.|.:|..    .|
  Fly   521 WVDEEQVFPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSG 585

  Fly   563 SEKHMDAFR 571
            ...|..|.:
  Fly   586 RNLHAQAHK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	219/547 (40%)
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	219/547 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448253
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32058at33392
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900