DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and Gm5134

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_006513854.1	Gene:	Gm5134 / 333669	MGIID:	3646667	Length:	695	Species:	Mus musculus

Alignment Length:	518	Identity:	109/518 - (21%)
Similarity:	205/518 - (39%)	Gaps:	129/518 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFV-SG--ITLLGLPTEV 81
            :.|..:.::|:|:.........:|.  |:.|.|:.:....:..|:.:|.: ||  :.|.|:..
Mouse    30 MTFYLLLVVCVGLWALLSHSRGTVK--DFFLAGQNLAWWLMGISIYSSNIGSGHYMALAGIGA-- 90

  Fly    82 YSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-A 144
             :.||....:....|.|..::|..::|::....:.:..|||:.|| ..|::|:.:.:|.|:.: :
Mouse    91 -ASGIAVGALEWNSIFMLFLLGWIFVPIYSKAEVVTLPEYLKKRFGSLRIQLFFTFIFLIVYIFS 154

  Fly   145 YLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQA-ISMLGALCLVAI 208
            .:.:.|...|:....|....::.....|..|...||..|||..|.:.:.:|| |.:||:..|:..
Mouse   155 RISMEIGFGAMFLKMVWDTDIYQTMLTVLTIIGMYTITGGLATVAYVESLQAGIMILGSALLMGY 219

  Fly   209 KGTRDIGGAGVVLER------------AWSSD------RLEA--------------PDLSIDPTV 241
             ...::||...::.:            .|::.      |.:|              |.|.:..|.
Mouse   220 -AFYEVGGYPKLVSKYMEAIPSKTQQGNWTAQPECYLPRQDAFHIFRSCVSGDIPWPGLILGATT 283

  Fly   242 RHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSLPSLGDARKAL---CIFCVGVL-----ILMALCG 298
                ..||:|         ...|..:||:|:    |.:|..:   |:.| |.|     .||.:.|
Mouse   284 ----VSLFYG---------CADQVSVQRFLA----GKSRLHMEGGCLLC-GYLKLLPMFLMVMPG 330

  Fly   299 YNGLLIY------ATYQNCDPLTTKLAKARDQLLPLFVMKTLGELP-GMTGLFIAGVFSAALSSL 356
            ....::|      .....|.....:.........|:.|   ||.:| |:.|..::.|.::.:|||
Mouse   331 MISRILYPDQVACVVPSECQKFCGRGTGCSALAYPVLV---LGVMPHGLQGFMLSTVCASLMSSL 392

  Fly   357 STCLNSMSAVVLEDFVKPYVKKPLSSSAINWI------MRLVVVG----VGVLCVCLVYV----- 406
            ::..||.||:             .:.:...||      ..|::.|    :.:|.|.:|::
Mouse   393 TSIFNSSSAL-------------FTLNIYTWIRPTATEKELMIAGRFFVIILLAVTIVWIPIIEM 444

  Fly   407 ------VEHMGTVLQ--LTMSLEAITNGPLFGIFTIGLFLPWINGNSA----LVGGVMGVIAM 457
                  .|:| .||:  ||.|:.|        :|.:.:|...:|...|    :||..:||..:
Mouse   445 APNEILFEYM-QVLKSCLTPSMTA--------VFLLAVFCKRVNEQGAFWGLIVGTTIGVFRL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	109/518 (21%)
Gm5134	XP_006513854.1	SLC5-6-like_sbd	26..695	CDD:382020	109/518 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740