DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and CG32669

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	203/594 - (34%)
Similarity:	319/594 - (53%)	Gaps:	52/594 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLP 78
            || ||.....:.::.:.||||:.|: .|..:..:|:|..|.|.|.|:||||:|||:|.:|:||:.
  Fly     6 AW-DYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVS 69

  Fly    79 TEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNV 143
            .|.|.||..::.::...:....|.....:|||:.|...|.|||||:||....||..|:.|::..|
  Fly    70 MENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQMV 134

  Fly   144 AYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAI 208
            .|:.||:|.||||...|||:.......||.::|.||.:|||:|||:.||:.|::.|..|:..|.|
  Fly   135 LYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFSVII 199

  Fly   209 KGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSL 273
            ......|...|:...|..:.|:...:.|:|||.|||::....||...:.....|:|..:||.:::
  Fly   200 CAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRLMAV 264

  Fly   274 PSLGDARKALCIFCVGVLILMAL--CGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGE 336
            .||..||.||. :|:.:|.|::|  | ::||.||..|::||||......:|||::||||:.|:||
  Fly   265 KSLSAARAALW-WCLPILCLLSLSTC-FSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMGE 327

  Fly   337 LPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYV----KKPLSSSAINWIMRLVVVGVG 397
            ..|:.|||::|:|.|:||::|:.::|::||.|||::||.|    |:.|:.....|..:|:.:..|
  Fly   328 YTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFG 392

  Fly   398 VLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSL 462
            .||:.:.::...:|.:||..:|:..|..|||.|:||:|:::...|...|:.|.::.:....|:..
  Fly   393 ALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWIGF 457

  Fly   463 NAQWAIASGAITYKTKP--LNVEQCDYSFNVTTSLANTTHLG-----ASAEDIFPLYRISYMWYT 520
            .            :.||  ::::.......|..|.|....|.     |..|..|.|||||||||.
  Fly   458 G------------QPKPPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYFYLYRISYMWYA 510

  Fly   521 TFGASITIFVALLGTFVFG----KNNP---NKVDPVLLTPCIRKFFAFGSEKHMDAFRPDIPLQH 578
            ..|..||.|...|.:::|.    .||.   ...|..|:             || |.|.|  |:..
  Fly   511 ALGFLITFFGGWLLSWLFALLKWDNNRRIYQDADCTLI-------------KH-DLFVP--PIAK 559

  Fly   579 KLRNDEVAL 587
            :|:..::.|
  Fly   560 RLQRRQMPL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	188/533 (35%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	189/534 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448275
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900