DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and Slc5a4

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001099853.1	Gene:	Slc5a4 / 294341	RGDID:	1306923	Length:	671	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	138/611 - (22%)
Similarity:	260/611 - (42%)	Gaps:	101/611 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82
            |....|..|::.:.:|::........:...:.|.||.|...|:..||.||.:.....:||.....
  Rat    39 DISVIVIYFVVVMAVGVWAMVKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGA 103

  Fly    83 SYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVM-FAIMNVAY 145
            :.||...........:.:|:|.|::|::....:.:..|||..|| .:||::|.||: ..|..:..
  Rat   104 ATGIAVTAFESHSFALLLVLGWFFVPIYIKAGVMTMPEYLRKRFGGKRLQIYLSVLSLFICVILT 168

  Fly   146 LPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKG 210
            :...|:..|:......|:.::....|:..|...:|..|||.:|::||.:|||.||....::.|..
  Rat   169 ISADIFSGAIFIKLALGLDLYLAIFILLAITAVFTITGGLASVIYTDTLQAIIMLVGSFILMIYA 233

  Fly   211 TRDIGGAGVVLERAWSS--DRLEAPDLSIDP---TVRHTFWCLF--------------FG----G 252
            ..::||.....|:..::  ..:|..:|:|.|   |.:...:.:|              ||    .
  Rat   234 FVEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHIFRDAVTGDIPWPGTAFGMPITA 298

  Fly   253 IVYWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVLIL-----MALCGYNGLLIYATYQNCD 312
            :.||    .::|.::||.|...::... ||.||.| |.|.|     |.:.|....::|.....|
  Rat   299 LWYW----CINQVIVQRCLCGKNMSHV-KAACIVC-GYLKLLPIFFMVMPGMISRILYTDMVAC- 356

  Fly   313 PLTTKLAK-------ARDQLLPLFVMKTLGELP-GMTGLFIAGVFSAALSSLSTCLNSMSAVVLE 369
            .:.::..|       ..:...|:.|:|.   :| |:.||.::.:.::.:|||::..||.|.:...
  Rat   357 VVPSECVKQCGVDVGCTNYAYPMLVLKL---MPMGLRGLMLSVMLASLMSSLTSIFNSASTLFTM 418

  Fly   370 D-FVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVE--HMGTVLQLTMSLEAITNGPLFGI 431
            | :.|  ::|..|...:....||.|..:.|..:..|.:||  ..|.::..|.::.:....|:..:
  Rat   419 DLYTK--IRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLIHYTEAISSYLGPPIAAV 481

  Fly   432 FTIGLFLPWINGNSA----LVGGVMGVIAMSWVSLNAQWAIASGAITYKTKPLNVEQCDYSFNVT 492
            |.:.:|...:|...|    :||.|:|:|.|          ||                ::|:...
  Rat   482 FLVAIFCKRVNEQGAFWGLMVGLVLGLIRM----------IA----------------EFSYGTG 520

  Fly   493 TSLANTTHLGASAEDIFPLYRISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRK 557
            :.||     .:|...:  :..:.|::|    |.|..||::|  .:.|.:...|  |:   |.:..
  Rat   521 SCLA-----PSSCPKV--ICGVHYLYY----AIILFFVSIL--VILGVSYLTK--PI---PDVHL 567

  Fly   558 FFAFGSEKHMDAFRPDIPLQHKLRND 583
            :....|.::.:..|.|:..:.:..|:
  Rat   568 YRLCWSLRNSEEERIDLDAEDREENE 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	130/563 (23%)
Slc5a4	NP_001099853.1	SLC5-6-like_sbd	38..671	CDD:294310	138/611 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740