DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001003915.1	Gene:	Slc5a12 / 241612	MGIID:	2138890	Length:	623	Species:	Mus musculus

Alignment Length:	573	Identity:	194/573 - (33%)
Similarity:	311/573 - (54%)	Gaps:	44/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLP 78
            || |||.|..:|::..|||::|... .|..:..::::|||:|...|:|.||.|||:|.:|:||.|
Mouse     8 AW-DYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFGPVALSLTASFMSAVTVLGTP 71

  Fly    79 TEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNV 143
            .|||.:|..:.......:.:.......:||||:...||||||||::||::.:|...::::.:..:
Mouse    72 AEVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYIVQTI 136

  Fly   144 AYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAI 208
            .|..:|:|.||||.|||||..:........|:|.||.||||||||||||..|.:.|:.....|.|
Mouse   137 LYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLI 201

  Fly   209 KGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSL 273
            :|:..:||...|||:|.:..||...|..:||..|||||.:..||...|.....|:|:.|||.:|.
Mouse   202 QGSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCISC 266

  Fly   274 PSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGELP 338
            .:...|:.||....:|:.|::|...::||::|:.:::|||.|:.:..|.|||:|.|||:....:|
Mouse   267 KTEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATMP 331

  Fly   339 GMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVK---PYVKKPLSSSAINWIMRLVVVGVGVLC 400
            |:.|||:|..||..||:::..:|:::.|..|||||   |::...||:    ||.:.:.:..|::|
Mouse   332 GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDKLST----WISKGLCILFGIMC 392

  Fly   401 VCLVYVVEHMGTVLQ----------LTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVI 455
            ..:..|...||:|:|          :|.|.:.......:|:....|.:      .||.|.:.|:.
Mouse   393 TSMAVVASLMGSVVQAPGIVSQERAITGSFQRNLASVCYGVSIWKLIM------GALGGLLTGIT 451

  Fly   456 AMSWVSLNAQWAIASGAITY-----KT--KPLNVEQCDYSFNVTTSLANTTHLGASAEDIFPLYR 513
            ...||::        |:..|     ||  .||:.|.| ...|:||::|..........|.:  |.
Mouse   452 LSFWVAI--------GSFIYPAPESKTLPLPLSTEHC-VELNITTTVAPQISSRPVLADTW--YS 505

  Fly   514 ISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKH 566
            :||::::..|....|...::.:|:.||.....:||:|:.| :...|.|.|:|:
Mouse   506 LSYLYFSAVGCLGCIAAGIIISFLTGKQRGKDIDPLLIRP-VCNLFCFWSKKY 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	181/540 (34%)
Slc5a12	NP_001003915.1	SLC5-6-like_sbd	3..531	CDD:294310	184/544 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836600
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840