Protein Alignment bumpel and SLC5A9

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_047304539.1
• Gene: SLC5A9 / 200010
• HGNCID: 22146
• Length: 745
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 122/555 - (21%)
• Similarity: 212/555 - (38%)
• Gaps: 148/555 - (26%)

  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82
            |....|..|:..|.:||:........:...|.|.||.|...||..||::|.|.....:||.....
Human    37 DISVVVIYFVFVIAVGIWSSIRASRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGA 101

  Fly    83 SYGI--------------------------------QYLYVS---------CGVIG--------- 97
            :.|:                                |..|.|         |..:|
Human   102 AGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQVSYFSVRGPPTAQHCLWVGSRPSVYIQD 166

  Fly    98 --------------MGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-AYL 146
                          :.:.:|..::||:....:.:..:||:.|| .:|:::|.||:..|:.: ..:
Human   167 LDTFFFSPLSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIFTKI 231

  Fly   147 PIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKGT 211
            ...|:..||......|..::..|.|:.::...||..|||.||::||.:|.:.|:|...::...|.
Human   232 STDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGF 296

  Fly   212 RDIG---GAGVVLERAWSSDRLEAPDLSIDPTVRH-----TF------------W-CLFFGGIVY 255
            :|:|   |    ||:.:   |...|::::..|..|     .|            | .|.||..|.
Human   297 QDVGWYPG----LEQRY---RQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPGLIFGLTVL 354

  Fly   256 WTQTNAVSQNMIQRYLSLPSLGDAR---------KALCIF------------------CVGVLIL 293
            .|......|.::||.||..||..|:         |.|.:|                  ||...:.
Human   355 ATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDPDVC 419

  Fly   294 MALCGYNGLLIYATYQNCDPLT-TKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSSLS 357
            ..:||        ....|..:. .||..|   |:|:          |:.||.||.:.:|.:|||:
Human   420 QRICG--------ARVGCSNIAYPKLVMA---LMPV----------GLRGLMIAVIMAALMSSLT 463

  Fly   358 TCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVEHMGTVLQLTMSLEA 422
            :..||.|.:...|..:.:.:|. :...:..:.|:.||.:.|:.:..:.:::...:. ||...::|
Human   464 SIFNSSSTLFTIDVWQRFRRKS-TEQELMVVGRVFVVFLVVISILWIPIIQSSNSG-QLFDYIQA 526

  Fly   423 ITN---GPLFGIFTIGLFLPWINGNSALVGGVMGV 454
            :|:   .|:..:|.:.:|...:....|..|.|.|:
Human   527 VTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGL 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	122/555 (22%)
SLC5A9	XP_047304539.1	SLC5sbd_SGLT4	37..745	CDD:271380	122/555 (22%)