Protein Alignment bumpel and SLC5A8

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 206/574 - (35%)
• Similarity: 326/574 - (56%)
• Gaps: 26/574 - (4%)

  Fly    16 WPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPT 79
            | |||.|..|.::...||||:.|. ....:..|:::|||:|..:|:|.||.|||:|.:|:||.|:
Human    13 W-DYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPS 76

  Fly    80 EVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNVA 144
            |||.:|..:...:.....:.|:....:||||:.|.|||||||||:||::.:||.|:|:|.:..:.
Human    77 EVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTIL 141

  Fly   145 YLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIK 209
            |..||||.||||.|||||..:........::|.||.:|||||||:||||.|...|:.....|.|:
Human   142 YTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQ 206

  Fly   210 GTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSLP 274
            .....||...:|..|:...||...:.:.:|..|||||.:..||...||....|:|:.:|||:|..
Human   207 AVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCK 271

  Fly   275 SLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGELPG 339
            |...|:.:|.|..||:..::....:.||.:|:.|.:|||.|.|...|.|||:|..|:..|.:.||
Human   272 SRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPG 336

  Fly   340 MTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLV 404
            :.|||:|..:|..||::|:.:|:::||.:||.:|||.:. ||..:::||.:.:.|..|.||:.:.
Human   337 LPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRS-LSERSLSWISQGMSVVYGALCIGMA 400

  Fly   405 YVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNAQWAIA 469
            .:...||.:||..:|:..:..|||.|:|.:|:.:|:.|...||||.:.|.....||.:.||   .
Human   401 ALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQ---I 462

  Fly   470 SGAITYKTKP--LNVEQCDYSFNVTTSLANTTHLGASAEDIFPLYRI------------SYMWYT 520
            ...:..:|.|  |:::.|:.::| .|:|..||.:..:. .:|.:|.:            ||::::
Human   463 YPPLPERTLPLHLDIQGCNSTYN-ETNLMTTTEMPFTT-SVFQIYNVQRTPLMDNWYSLSYLYFS 525

  Fly   521 TFGASITIFVALLGTFVFGKNNPNKVDP-VLLT--PCIRKFFAFGSEKHMDAFR 571
            |.|..:|:.|.:|.:...|....| :|| .:||  ..:..|..|..:||:.:::
Human   526 TVGTLVTLLVGILVSLSTGGRKQN-LDPRYILTKEDFLSNFDIFKKKKHVLSYK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	195/534 (37%)
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	197/542 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610