DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6723 and SLC5A12

DIOPT Version :9

Sequence 1:NP_650069.2 Gene:CG6723 / 41368 FlyBaseID:FBgn0037895 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_848593.2 Gene:SLC5A12 / 159963 HGNCID:28750 Length:618 Species:Homo sapiens


Alignment Length:571 Identity:196/571 - (34%)
Similarity:323/571 - (56%) Gaps:33/571 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ELQRFAWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGIT 73
            |::.||..|||.|.::|.:..|||::|... .|..:..::::|||:|...|:..||.|||:|.:|
Human     2 EVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVT 66

  Fly    74 LLGLPTEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMF 138
            :||.|:|||.:|..:|......:.:.::....:||||:...||||||||::||::.:|...:|::
Human    67 VLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIY 131

  Fly   139 AIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGAL 203
            .:..:.|..:|:|.||||.|||||..:........|:|.||.:|||||||||||..|.:.|:...
Human   132 IVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGF 196

  Fly   204 CLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQ 268
            ..|.|:|:...||...|||::.:..||...|..:||..|||||.:..||...|.....|:|:.||
Human   197 LTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQ 261

  Fly   269 RYLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKT 333
            |.:|..:...|:.||....:|:.|::....::||::|:.:::|||.|:.:..|.|||:|.|||:.
Human   262 RCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEI 326

  Fly   334 LGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVK---PYVKKPLSSSAINWIMRLVVVG 395
            ...:||:.|||:|..||..||::::.:|:::.|..|||||   |::...||:    ||.:.:.:.
Human   327 FATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLST----WISKGLCLL 387

  Fly   396 VGVLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWV 460
            .||:|..:......||.|:|.::|:..:..||:.|:|::|:..|::|...||.|.:.|:....||
Human   388 FGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWV 452

  Fly   461 SLNAQWAIASGAITYKTKPLNVEQCDYSFNVTTS----------LANTTHLGASAEDIFPLYRIS 515
            ::.|....|..:.|:.. ||:.:||..| |||.:          :|:|            .|.||
Human   453 AIGAFIYPAPASKTWPL-PLSTDQCIKS-NVTATGPPVLSSRPGIADT------------WYSIS 503

  Fly   516 YMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKH 566
            |::|:..|....|...::.:.:.|:.....:.|:|:.| :...|.|.|:|:
Human   504 YLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRP-VCNLFCFWSKKY 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6723NP_650069.2 SLC5sbd_NIS-SMVT 17..537 CDD:271383 185/533 (35%)
SLC5A12NP_848593.2 SLC5sbd_SMCT2 3..527 CDD:212089 187/541 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146500
Domainoid 1 1.000 49 1.000 Domainoid score I11782
eggNOG 1 0.900 - - E1_COG0591
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1180002at2759
OrthoFinder 1 1.000 - - FOG0000151
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR42985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X112
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.850

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