Protein Alignment bumpel and SLC5A10

DIOPT Version :10

• Sequence 1: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_016879680.2
• Gene: SLC5A10 / 125206
• HGNCID: 23155
• Length: 649
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 129/613 - (21%)
• Similarity: 238/613 - (38%)
• Gaps: 139/613 - (22%)

  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82
            |.:.....|.|.:.:||:........:.:.|.|.||.|...||..||.||.......:||.....
Human    20 DIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGA 84

  Fly    83 SYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-AY 145
            :.|:...........:.:.:...::|::....|.:..||::.|: .:|:|:|.||:..:::| ..
Human    85 AGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTK 149

  Fly   146 LPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKG 210
            :.:.:|..||..:...|...:..|.:...|...||..|||.||::||.:|.:.|:....::.||.
Human   150 ISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKA 214

  Fly   211 TRDIGGAGVVLERAWSS--------------DRLEAPDLSIDPTVRHTFWC-LFFGGIV----YW 256
            ...|||.| .||.|::.              .|.:|..:..||......|. :.||..:    ||
Human   215 FDQIGGYG-QLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYW 278

  Fly   257 TQTNAVSQNMIQRYLSLPSLGDARKA------LCIFCVGVLILMALCG---YNGLLIYATYQNCD 312
                ...|.::||.||...|..|:..      |.:..:|::|:..:..   :.|..:|.....
Human   279 ----CTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPGAHVYEERHQ-- 337

  Fly   313 PLTTKLAKARDQ--LLPLFVMKTLGE----------------LP-GMTGLFIAGVFSAALSSLST 358
               ..:::..|.  ::|...::..|.                :| |:.||.||.:.:|.:|||::
Human   338 ---VSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTS 399

  Fly   359 CLNSMSAVVLEDF---VKPYVKK---------------PLSSSAIN-----------WIMRLVVV 394
            ..||.|.:...|.   ::|...:               |...|.::           :::.|||:
Human   400 IFNSSSTLFTMDIWRRLRPRSGERELLLVGRTGIPSTPPAPQSRLSFLLPETPPLERYLLGLVVM 464

  Fly   395 GVGVLCVCLVYVVEHMGTVL------QLTMSLEAITNG---PLFGIFTIGLFLPWINGNSALVGG 450
            .:.::.|.|:.|......||      ||.:.::::|:.   |:..:|.:|:|....|...|..|.
Human   465 DLWLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGL 529

  Fly   451 VMGVI-----------------------------------AMSWVSLNAQWAIASGAITYKTKPL 480
            :.|::                                   |::..:|:....:|...:|...:.:
Human   530 IAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSV 594

  Fly   481 NVEQCDYSFNVT-TSLANTTHLGASAED 507
            .:|      |:| .:||....||..|.|
Human   595 QIE------NLTWWTLAQDVPLGTKAGD 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	129/613 (21%)
SLC5A10	XP_016879680.2	SLC5-6-like_sbd	17..649	CDD:444915	129/613 (21%)