DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6723 and slc5a8

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_021331097.1	Gene:	slc5a8 / 100329285	ZFINID:	ZDB-GENE-141211-63	Length:	609	Species:	Danio rerio

Alignment Length:	548	Identity:	181/548 - (33%)
Similarity:	273/548 - (49%)	Gaps:	60/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WPDYVAFVSMFLLCIGIGIYFGFMNKSVSED-DYMLGGRKMLVIPIAFSLVASFVSGITLLGLPT 79
            | |||.|:.|..:..|||:|:.|..:|.|.. |:::.||.:...|:|.||.|||:|.||:||.|.
Zfish    11 W-DYVVFIMMLAVSTGIGVYYAFAARSQSSSADFLVAGRSLSAPPVALSLTASFMSAITVLGTPV 74

  Fly    80 EVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNVA 144
            |||.||..::.:......|..:....:||||:.|.:|||||                      |.
Zfish    75 EVYKYGAIFILICFAYAFMVALSSEIFLPVFYRLGVTSTYE----------------------VL 117

  Fly   145 YLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIK 209
            |..:|||.||||.|||||:.:........::|..|.:||||||||||||.|...||..|..|.::
Zfish   118 YTGLVIYAPALALNQVTGVDLWGAVISTGVVCTLYCTLGGLKAVVWTDVFQVGIMLAGLLAVIVQ 182

  Fly   210 GTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSLP 274
            .....||...::..:....|:...|...:|..|||||.:..||..|||....::...:|||:|..
Zfish   183 SVLLQGGIPRIISDSAHGGRINLWDFDPNPLRRHTFWSITVGGTFYWTSFYGINHAQVQRYISCK 247

  Fly   275 SLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGELPG 339
            ||..|:.||.|..|.:.::.....:.||.:|:.|:||||...|...|:|||:|..|:..|.|.||
Zfish   248 SLIHAKMALFINLVTLWVVTFCAVFCGLCLYSVYKNCDPWMAKKVSAQDQLMPYLVLDILSEFPG 312

  Fly   340 MTGLFIAGVFSAAL-----SSLSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVL 399
            :.|||:|..:|...     |::|:.:|:::||.:.|.::||:.  ||...::|..:.:.:..|.:
Zfish   313 LPGLFVAAAYSGTFMFIVNSTVSSSVNALAAVTVTDVLRPYLS--LSEKQLSWASKAMSLFYGAV 375

  Fly   400 CVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNA 464
            |:.:..:...||.:||...|:..:..|||.|:|::.:..|..|....|.|.|.|:....||.:.|
Zfish   376 CIGMAGIASMMGGMLQAAFSISGVIGGPLLGLFSLAILFPCANSKGGLAGLVSGLGLSLWVCIGA 440

  Fly   465 QW----AIASGAITYKTKPLNVEQCDYSFNVTTSLANTTHLGASAEDIF---------PL----- 511
            |.    |..|..:|..|...|:.....:.|.|.|:           ||:         ||
Zfish   441 QIYPPPAENSRPLTLNTHGCNLSMAPDTTNWTASM-----------DIYRIEEETLERPLLADNW 494

  Fly   512 YRISYMWYTTFGASITIFVALLGTFVFG 539
            |.:||:::...|....|.|.|:.:.:.|
Zfish   495 YSLSYLYFGLLGTVTAIAVGLIVSILSG 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	179/543 (33%)
slc5a8	XP_021331097.1	SLC5-6-like_sbd	6..527	CDD:320982	181/548 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950