DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6723 and slc5a3a

DIOPT Version :9

Sequence 1:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001153309.1	Gene:	slc5a3a / 100004287	ZFINID:	ZDB-GENE-090312-3	Length:	671	Species:	Danio rerio

Alignment Length:	482	Identity:	116/482 - (24%)
Similarity:	206/482 - (42%)	Gaps:	61/482 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVYSY 84
            ||...:.:||.|....:.....:||  .|.|.||.|....|..||..|.:.....:||.....:.
Zfish    13 VAMYFVLVLCFGFFSMWRANRGTVS--GYFLAGRSMNWFVIGASLFVSNIGSEHFIGLAGSGAAS 75

  Fly    85 GIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLY-GSVMFAIMNVAYLP 147
            |:.........|.:..::|..::||:....:.:..|||..|| ..||::| .|:...:.....|.
Zfish    76 GLAVGAWEFNAILLLQLLGWVFIPVYIHSGVYTMPEYLSKRFGGNRLKIYFASLTLLLYIFTKLS 140

  Fly   148 IVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISML-GALCLVAIKGT 211
            :.:|..||...:..|..::....::..:....|..|||.||::||.:||..|: |||||:||...
Zfish   141 VDLYSGALFIQESLGWNLYLSIILLITLTALLTVTGGLVAVIYTDTLQAFLMISGALCLMAISLV 205

  Fly   212 RDIGG---------------AGVVLER--AWSSD-----RLEAPDLSIDPTVRHTFWCLFFGG-- 252
            : :||               ..:.||.  .:|:.     :.::..|...|..:...|..|..|
Zfish   206 K-VGGLEGLRTKYMNALPNITFITLENNLTYSNSCHVNPKADSFKLLRSPLDKDLPWPAFLLGQT 269

  Fly   253 ---IVYWTQTNAVSQNMIQRYLSLPSLGDARKALCIFCVGVL-----ILMALCGYNGLLIYATY- 308
               |.||    ...|.::||.|:..::..|:.:..:  .|||     .::.:.|....:::|..
Zfish   270 PASIWYW----CADQVIVQRVLAARNIAHAKGSTLL--AGVLKVLPMFIIVIPGMISRVLFADEL 328

  Fly   309 -----QNCDPLTTKLAKARDQLLPLFVMKTLGELP-GMTGLFIAGVFSAALSSLSTCLNSMSAVV 367
                 ::|..:....|...:...|..||..   :| |:.||.:|.:.:|.:|.|.:..||.|.:.
Zfish   329 ACIGPEHCMQVCNSRAGCTNTAYPRLVMNI---MPVGLRGLMMAVMLAALMSDLDSIFNSASTIF 390

  Fly   368 LEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLV-YVVEHMGTVLQLTMSLEAITN---GPL 428
            ..|..| .::...||..:..:.||.||.:..:.:..| :|:|..|.  |:.:.::.:::   .|:
Zfish   391 TLDIYK-MIRHQASSKELMVVGRLFVVLIVAISIAWVPFVIEMQGG--QMFLYIQEVSDYLTPPI 452

  Fly   429 FGIFTIGLFLPWINGNSALVGGVMGVI 455
            ..:|.:|:.....|...|..||.:|:|
Zfish   453 AALFLLGVLWKRCNETGAFWGGFVGLI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	116/482 (24%)
slc5a3a	NP_001153309.1	SLC5-6-like_sbd	9..671	CDD:294310	116/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740