DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and IPO9

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_060555.2	Gene:	IPO9 / 55705	HGNCID:	19425	Length:	1041	Species:	Homo sapiens

Alignment Length:	1046	Identity:	390/1046 - (37%)
Similarity:	606/1046 - (57%)	Gaps:	77/1046 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYV 77
            :|:|:::.|..:||....|....|::||.||.||.:||:|:|:.::....|.:||:|.|:|.:||
Human    21 LKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYV 85

  Fly    78 ENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAEL 142
            |.||....:..|...   .:|:||..||.:|||||.:..||:|||||:.:|.||..|:|..|.:|
Human    86 ETHWCAQSEKFRPPE---TTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDWPEAWPQL 147

  Fly   143 FDIIVKCL-GGNEDSIHGAMQVLQDFSYDV--EQIKELGPVVIPEVYRIFDSEQNYSIKTRVSAI 204
            |:::::.| .|:.:::||||:||.:|:.:|  .|:..:.||::||:|:||...:.|.|:||..|:
Human   148 FNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSRAV 212

  Fly   205 RILKPLFASIAALITNKEE-----QSTMMSSILTNFMDKLMHYLSMNSGAVSSFLLRTEIIKVFT 264
            .|    |.:.|.:|.|.||     ...::..::..|.:..:..|.:..|..|....:.|::|..|
Human   213 EI----FTTCAHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVT 273

  Fly   265 HLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTE--TSPLASGDSEEDDEQTNFQSLI 327
            .||...||::...|.::|||||..||:.|..||:..||.||  ..|:     :.|.|...|::|:
Human   274 ALVKNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPV-----DSDGEVLGFENLV 333

  Fly   328 IQILEFINCILTCNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVELTV 392
            ..|.||::.:|..:|.:.::|..|.:|||..|:|:|::|||::.|..:|::||:||||.....||
Human   334 FSIFEFVHALLENSKFKSTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTV 398

  Fly   393 RMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFR----D 453
            |:..:|:|||:..:|...:...|..|..||...|:..|.:...:||||.||||.|:.:.:    |
Human   399 RIAAQDLLLAVATDFQNESAAALAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITD 463

  Fly   454 VILAGDSTFDLLNYLTIV----RNLLVHQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLC 514
            .:..|...||:..:||.|    .||.|   ||.|:|||||..|.::.:  .:|:::.:.|..|:.
Human   464 SVKNGRIHFDMHGFLTNVILADLNLSV---SPFLLGRALWAASRFTVA--MSPELIQQFLQATVS 523

  Fly   515 SLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEA 579
            .|...:...:||||||.:.|:  .::....|...:|...||..|||::.|.....:.||.|:||.
Human   524 GLHETQPPSVRISAVRAIWGY--CDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMET 586

  Fly   580 LTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTI 644
            |..:...|.||..:.::||.|..||:||||:.||.|....||:.|.|.|.:.|.||:|.:.|||:
Human   587 LCIVCTVDPEFTASMESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTL 651

  Fly   645 VSILGL------TGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINCVLHTDDHAVMV 703
            |||:..      .|..:|     |:|:|.|:||.|:|||:..|:..||||:..|.|||||:|.|.
Human   652 VSIMQAPADKIPAGLCAT-----AIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQ 711

  Fly   704 AGGECLRSFINVSPEQICSYKNGEGIN---CIMQVVATVLLNPMNSEMTAAGQIGRLVITIITKM 765
            .||||||::::|:.||:..:.:.:|.|   .:||||:. ||:|..||.||| .:||||.|:|:|.
Human   712 NGGECLRAYVSVTLEQVAQWHDEQGHNGLWYVMQVVSQ-LLDPRTSEFTAA-FVGRLVSTLISKA 774

  Fly   766 GSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVLNFLSTVPGPNGEPAMQFV 830
            |..||:|:|.:|:|::||||..|.|.|:.:|:::||||..||::.:|.||.::|||.|:||::||
Human   775 GRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFV 839

  Fly   831 LTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFK--ELVDDPTDTRRRTRSVAA 893
            :..|.|||:.|:|.||.||:::|||||.::|:...|.||..|..|  |:.......|.|::| |.
Human   840 MAEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKS-AK 903

  Fly   894 TTQKWVTIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDD-----EDAPGNPDKP------R 947
            ..::|..||.||||.|::|:|..:..|..:....|.:|...||     ||.....::.      :
Human   904 NPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEEEEDGLAGQ 968

  Fly   948 YISDL-----FESD--EDNAEDEQLLQELLKETNYQGDIADNLQKFLTTFTQNEHFPTFYEHLTE 1005
            .:||:     :|.|  ||:.||:   .:.||:..||.|:...|..||..|.|...:..|..||.:
Human   969 LLSDILATSKYEEDYYEDDEEDD---PDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSGHLND 1030

  Fly  1006 GERLIL 1011
            .||.:|
Human  1031 NERRVL 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	347/905 (38%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	33/77 (43%)
IPO9	NP_060555.2	CSE1	34..812	CDD:227944	304/803 (38%)
IPO9	NP_060555.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..967		6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152751
Domainoid	1	1.000	583	1.000	Domainoid score	I208
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5874
Inparanoid	1	1.050	649	1.000	Inparanoid score	I798
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55070
OrthoDB	1	1.010	-	-		D364997at33208
OrthoFinder	1	1.000	-	-		FOG0005540
OrthoInspector	1	1.000	-	-		oto91472
orthoMCL	1	0.900	-	-		OOG6_103714
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R604
SonicParanoid	1	1.000	-	-		X4496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800