DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and ipo11

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_005167213.1	Gene:	ipo11 / 432373	ZFINID:	ZDB-GENE-040711-1	Length:	975	Species:	Danio rerio

Alignment Length:	1105	Identity:	233/1105 - (21%)
Similarity:	421/1105 - (38%)	Gaps:	266/1105 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SVKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRY 76
            |....:::.|....|.||.||:..|::::|.|...|:...|..|..|...::.:|.:|::.....
Zfish     5 SASSVVLQALTQATSQDTAVLKPAEEQLRQWETQPGFYSVLLSIFNNHLLDVNVRWLAVLYFKNG 69

  Fly    77 VENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAE 141
            ::.:|       |:......||:.|.::|..|.....:|.::|.:.:|..|:.:|..|.|..|.|
Zfish    70 IDRYW-------RRVAPHALSEEEKSSLRAGLITNFNEPVNQIATQIAVLIAKVARLDCPRQWPE 127

  Fly   142 LFDIIVKCLGGNEDSI--HGAMQVLQDFSYDVEQI---------KELGPVVIPEVY--------- 186
            |..|:::.: ..:||:  |.|:...    |.|.:.         :.|...:...:|
Zfish   128 LIPILLESV-KVQDSLQQHRALLTF----YHVTKTLASKRLATDRRLFQDLASSIYSFACSLWNH 187

  Fly   187 -------RIFDSEQN---YSIKTRVSAIRILKPLFASIAALITNKEEQSTMMSSILTNFMDKLMH 241
                   :|:..:|.   .|::..:.::::|:.|  ::...:..:.....|  ..|....::|..
Zfish   188 HTDSFLQQIYSGDQQTALSSLERTLLSLKVLRKL--TVHGFVDPQNNMEVM--GFLNAVFERLKQ 248

  Fly   242 YL----SMNSGAVSSFLLRTEIIKVFTHLVNEMPKYIN-PFMDRVLPIVWQLLTQIAETYVKVSV 301
            :|    .:..|:.....|...|| :||.::.:..:|.. ||    :|::.:.| :.|.:||
Zfish   249 FLECCRQVGPGSPCREKLEKTII-LFTKVLLDFLEYHPCPF----IPLIQRSL-EFAVSYV---- 303

  Fly   302 NQTETSPLASGDSEEDDEQTNFQSLIIQILEFINCILTCNKLRGSIKNV--------------LA 352
                        ..|..|...|:..|:|.:..|..|:. |......||:              .|
Zfish   304 ------------FTEAGEGVVFERFIVQCMNLIKMIVK-NDAYKPAKNIEDSKPESLEAHRIKTA 355

  Fly   353 DLIYITIV---------YIQLSEEQLEDWHDDPEKFVDDEDDG-GVELTVRMCGRDVLLAINDEF 407
            ...:.|:.         |..|:||:|..|.:|||.|..:|..| ..:.::|.....:.|.|...:
Zfish   356 FFTHQTLTEIGRRLVSKYFLLTEEELTMWEEDPESFAVEETGGDSWKYSLRPSTEVLFLDIFHNY 420

  Fly   408 GANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFRDVILAGDSTFDLLNYLTIVR 472
            .......|.|.:......::.|    :|    :|....|||  :..|.||....||.:::....:
Zfish   421 SQTLTPVLLEMVQNLQGPSNVE----DP----VQMLMKDAV--YNAVGLAAYELFDNVDFDQWFK 475

  Fly   473 NLLV------HQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRT 531
            |.|:      |.....:..|.:|.:..:. |..:.|::...:.:|.| ||..:...::||....|
Zfish   476 NQLLGELQVSHNRYKLIRRRVIWLIGQWI-SVKFKPELRPLLYEVIL-SLMQDPDLVVRIETATT 538

  Fly   532 LNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQA 596
            |...:.     |.|.||  ...|| :|:           ::.:||.:.|..:.:.|.:.......
Zfish   539 LKLAVD-----DFEFRT--EQFLP-YLE-----------SIFSLLFQLLQQVNECDTKMQVLHVI 584

  Fly   597 KITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQDI 661
            ......:::.::    |||...|| .:..|.::.|....|:...:.|::.::...||.|......
Zfish   585 SCVIERVSIQIR----PYVGCLVQ-YLPLLWKQSEEHNMLRCAILTTLIHLVQGLGAESKNLYPF 644

  Fly   662 ALDVLNTIVRYTEPP----LNNSL------LETAFPAIINCVLHTDDHAVMVAGGECLRSFINVS 716
            .|.|:......::||    |.:.|      ||.: |||.               .|.||.|.|:|
Zfish   645 LLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENS-PAIT---------------PELLRIFQNMS 693

  Fly   717 PEQICSYKN----GEGINCIMQVVATVLLN-----------PMNSEMTAAGQIGRL-VITIITKM 765
            |....|.:|    .:.||..:.:.||..|.           .:.|::|..||:..| |:.|..|:
Zfish   694 PLLELSSENVRTCFQIINAYIYLSATDFLQNYAEALCRSFCELLSDITNEGQVQVLKVVEIAIKV 758

  Fly   766 GSMLGQNV-DMLLKAVISKMQNLECLKVIMNLVL------------IFAHLFLTQMDAVLNFLST 817
            ..:||.:: ..||.:||..:...|...|:|:..|            .|..| ||||....|
Zfish   759 SPILGSHMFQPLLPSVIRGIVEGERYPVVMSTYLGVTGRILLQNSGFFTSL-LTQMAVEFN---- 818

  Fly   818 VPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFKELVDDPT 882
               ...:..:..::..|:.|.::......||::.:||..|.     ..||.:....|..:::
Zfish   819 ---QEADQLLGSMIEMWVDRMDNITQPERRKLSALALLSLL-----PSDNSVIQDKFCGIIN--- 872

  Fly   883 DTRRRTRSVAATTQKWVTIPALVKI---------FK--VLISEYQHFQEGKSDEPLTDSEEDGDD 936
                            :::.||..:         ||  :|:|   ||:|.|    ||      ||
Zfish   873 ----------------ISVEALHDVMTEDPETATFKDCMLMS---HFEEPK----LT------DD 908

  Fly   937 EDAPGNPDKPRYISDLFESDEDNAEDEQLLQELLK-------ETNYQG-------DIADNLQKFL 987
            |:.|...||.|.:..| |....:...:|.:.|.||       :..:|.       :|...||:|:
Zfish   909 EEPPTEQDKRRKLLAL-EDPVHSVSLQQFVYEKLKAQQMLMGDQGFQALMETVDTEIVRQLQEFI 972

Fly 988 987
Zfish 973 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	202/980 (21%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	16/77 (21%)
ipo11	XP_005167213.1	CSE1	10..>760	CDD:227944	175/840 (21%)
		IBN_N	28..100	CDD:281761	16/78 (21%)
		HEAT repeat	515..545	CDD:293787	8/35 (23%)
		HEAT repeat	559..586	CDD:293787	4/26 (15%)
		HEAT repeat	599..630	CDD:293787	7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910