DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and kap114

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_593739.2	Gene:	kap114 / 2541885	PomBaseID:	SPAC22H10.03c	Length:	993	Species:	Schizosaccharomyces pombe

Alignment Length:	1024	Identity:	230/1024 - (22%)
Similarity:	430/1024 - (41%)	Gaps:	126/1024 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYV 77
            |:..||:.|:.:.|:|.....|.|..::.||....:...|::|..:.| .:||||.:::.|.||:
pombe     2 VESKIIKLLEQVQSADPNSRIQAELGLRDLEKYHDFAAKLTDIASSGA-SVPLRQGSLIYLQRYI 65

  Fly    78 ENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYD-PNSKIRSSVAHTISTIAATDYPHCWAE 141
            .:||:  ...::..:|.:..|..|:.:|..|.:.|.. .|..:..:||:.:|.||..|||..|.|
pombe    66 VHHWS--PLFEQFQDGPIPDENVKKHVRETLLHLLVSLDNFTLIKAVAYAVSLIANVDYPDEWPE 128

  Fly   142 LFDIIVKCL-GGNEDSIHGAMQVLQ---DFSYDVEQIKELGPVVIPEVYR-IFDSEQNYSIKTRV 201
            :...::..| ..||:||:.::.||.   |.|...||...:.|.:...:|: ||.:..|.|:  |:
pombe   129 VVPAVLHLLQSTNENSINASLDVLDELVDESLVEEQFFIIAPQLASILYQFIFSAPPNDSM--RM 191

  Fly   202 SAIRILKPLFASIAALI-----TNKEEQSTMMSSILTNFMDKLMHYLSMN---------SGAVSS 252
            ...|.:| ||.|...||     |..|.....:..||..:||...|...::         ..:...
pombe   192 LQARGIK-LFRSCLELIEIYKETKAEHVRVFLEQILPPWMDMFSHKFEVSLVDDRQVILPDSCGY 255

  Fly   253 FLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDSEED 317
            |.:..||....|.|....|..:.|::...:.:||.::.::.:.|::..|........|.||...
pombe   256 FCIMGEIAMTLTKLRELFPSKLTPYVVTFVELVWNIIEKLLDPYIREVVFSDGLDDSAFGDKYP- 319

  Fly   318 DEQTNFQSLIIQILEFINCILTCNKLRG-SIKNV-----LADLIYITIVYIQLSEEQLEDWHDDP 376
                  ...::::|.|::..|....::. .:.|.     |...|.:.:.|.||.:.|:|.:..|.
pombe   320 ------IRYLVELLLFVSVALQSKFVQNLFVSNTVPVPPLPPCIPLLVQYTQLPKHQIEVYESDV 378

  Fly   377 EKFVDDE------DDGGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNP 435
            .:::.:|      .|     |||.....||.|    |..:...|:|::| |..|   |....||.
pombe   379 SEYIANEFSMDFASD-----TVRGAAISVLSA----FEEHTTLPIQQSL-REMS---ATYILNNE 430

  Fly   436 NWWKIQEACMDAVHAFRDVILAGDSTFDLLNYL----TIVRNLLVHQESP-PLVGRALWTLSIYS 495
            ..|..|||.:   :|...|..|.|.|:|  :||    ..::..:.:.::| .|:.|....:..:|
pombe   431 INWIYQEALL---YACCSVDAASDDTYD--DYLDPIYEAIKVRIDYSDAPILLLSRFFLFIGYFS 490

  Fly   496 KSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDG 560
            :|.:...|....|::..:.:|..:   .::.:|::.:..|...     |:.:.:| |..|..|:.
pombe   491 ESTVVASQFFQIIMNNLVNALQVD---TVQYAAMKAIERFCSV-----GKVKPIL-SLQPMILEV 546

  Fly   561 IMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKA 625
            :......|....|.||:||::..||.|...|......:.||...:......|||:...::|..:.
pombe   547 LSQYASKSSDEALVLLVEAISSAVKLDCAKAAELGNSVIPLLFNLVATNASDPYICGIIEDTFED 611

  Fly   626 LCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQD-----IALDVLNTIVRYTEPPLNNSLLETA 685
            :.........:.|..:|.::.:|        .::|     |...:|:.::|....||.|..:...
pombe   612 IIHAANNYESMCEITLPELLQVL--------NQEDPIMVNIGATLLSCLIRAGPSPLPNGFVGYV 668

  Fly   686 FPAIINCV-LHTDDHAVMVAGGECLRSFINVSPEQI--CSYKNGEGINCIMQVVATVLLNPMNSE 747
            .|.:.... :|:.|..::....|.|:..:.....|:  .......|...|:.::..:|  ...|:
pombe   669 LPPVYKITQIHSGDTELLQLSQEILKGLLEKDTPQLLETEISGSSGFQYILFILHQLL--DKESD 731

  Fly   748 MTAAGQIGRLVITIITKMGSMLGQNVDM--LLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDA 810
            .:|...:|    .|:.::.....|.||:  :|.:.|.::...|..:.|.:::.:||.|.:.....
pombe   732 DSACFLVG----PILLELADHASQMVDLQSILLSCIKRLAIAEQPRFIQSIIYVFAKLIVKDSLG 792

  Fly   811 VLNFL-STVPGPNGEPAMQFVLTNWLSRQNSFFGNYER-KVTTMALCKLFEYGVATQDNRLTTIT 873
            :::|| |::....|..|.:.::|.|.. ...:|.|::. .:..:|:.|::.:    ....|.::.
pombe   793 MMHFLTSSLLNEQGLTAFEVLMTVWCD-NFVYFSNFKNISIICIAMTKIYSF----DSPLLDSVQ 852

  Fly   874 FK-ELVDDPTDTRRRTRSVAAT-TQKWVTIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDD 936
            .| ||:..  ..|..|||.:.. .:::..:....||.::|..|:....:....|.::|...| |.
pombe   853 VKGELISH--SNRIITRSQSKLHPEEYSYVSVGEKILRLLSEEFVSLSKDAIVEEVSDDGAD-DW 914

  Fly   937 EDAP--------GNPDKPRYISDLF-----ESDEDNAEDEQLLQELLKE 972
            :|.|        ...|......|.|     ..||||.:.:..|.|..||
pombe   915 DDGPISAETFGLSANDVNELSKDEFSGVDNSEDEDNTDLQFYLLEFFKE 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	207/926 (22%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	21/77 (27%)
kap114	NP_593739.2	CSE1	1..993	CDD:227944	230/1024 (22%)
kap114	NP_593739.2	IBN_N	24..100	CDD:281761	21/78 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	130	1.000	Domainoid score	I1332
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1240
OMA	1	1.010	-	-		QHG55070
OrthoFinder	1	1.000	-	-		FOG0005540
OrthoInspector	1	1.000	-	-		oto102004
orthoMCL	1	0.900	-	-		OOG6_103714
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R604
SonicParanoid	1	1.000	-	-		X4496
TreeFam	0	0.000	Not matched by this tool.
	12	11.900