DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and CSE1L

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001307.2	Gene:	CSE1L / 1434	HGNCID:	2431	Length:	971	Species:	Homo sapiens

Alignment Length:	1072	Identity:	194/1072 - (18%)
Similarity:	369/1072 - (34%)	Gaps:	313/1072 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DCGDSVKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVM 72
            :..|:..|.:.|.|:..|..|..:.:..||.::.:|..:.|.:.|. .::.::.:..::..|.|.
Human     2 ELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLL-TLLEKSQDNVIKVCASVT 65

  Fly    73 LTRYVENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPH 137
            ...|::.:|...:|...|.  |.|...|.:.  ||:...|..| .:|:..::..||.|...|:|.
Human    66 FKNYIKRNWRIVEDEPNKI--CEADRVAIKA--NIVHLMLSSP-EQIQKQLSDAISIIGREDFPQ 125

  Fly   138 CWAELF-DIIVKCLGGNEDSIHGAMQ----VLQDFSYDVE------QIK-ELGPVVIP------E 184
            .|.:|. :::.:...|:...|:|.::    :.:.:.::.:      :|| .|....:|      .
Human   126 KWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKA 190

  Fly   185 VYRIFDSEQNYSIKTRV--SAIRILKPLFASI----------------------------AALIT 219
            ...:..:..|.:...|:  |::.::..||.|:                            ..|.|
Human   191 TIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQT 255

  Fly   220 NKEEQSTMM----SSILTN-------FMDKLMHYLSMNSGAVSSFLLRT-EIIKV---------F 263
            :.||::.::    |.|..|       :.::...||.....|:.:.|:.| :.:|.         |
Human   256 DDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQF 320

  Fly   264 THLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDSEEDDEQTNFQSLII 328
            ...|.|.|.|.|.|.|:      ..||.|.|..:..::........|..|:.|:..:.:.:...|
Human   321 LASVCERPHYKNLFEDQ------NTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDI 379

  Fly   329 QILEFINCILT---CNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVEL 390
            .......|.|.   |....|.:..:.:.  |:..:..:.::....:|         ...|..:.|
Human   380 DTRRRAACDLVRGLCKFFEGPVTGIFSG--YVNSMLQEYAKNPSVNW---------KHKDAAIYL 433

  Fly   391 TVRMCGRDVLLAINDEFG---ANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFR 452
            ...:..:    |...:.|   ||.:..|.|....|. :.|.:.|  |.|.:.:.:|
Human   434 VTSLASK----AQTQKHGITQANELVNLTEFFVNHI-LPDLKSA--NVNEFPVLKA--------- 482

  Fly   453 DVILAGDSTFDLLNYLTIVRN-------------LLVHQESPPLVGRA--------LWTLSIYSK 496
                      |.:.|:.|.||             |:.|.::..:|...        |:|:...:.
Human   483 ----------DGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNN 537

  Fly   497 SDLYNPQMLTEILDVTLCSL--------SPEKSHILRISAVRTLNGFLQANETI---------DG 544
            :.|:....:...:::.|.:|        |.|..:|::    ..:..|....|.|         ..
Human   538 ATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMK----AIMRSFSLLQEAIIPYIPTLITQL 598

  Fly   545 EKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQAKITPLAIAVFLKY 609
            .::.|.|||.|            ||......:.||:...::...:   |:.|.:.....|:||.:
Human   599 TQKLLAVSKNP------------SKPHFNHYMFEAICLSIRITCK---ANPAAVVNFEEALFLVF 648

  Fly   610 TEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQDIALDVLNTIVRYTE 674
            ||   :|:  .|:               ::|||.:..::.|  ...|.|.||....:.......:
Human   649 TE---ILQ--NDV---------------QEFIPYVFQVMSL--LLETHKNDIPSSYMALFPHLLQ 691

  Fly   675 PPL----NNSLLETAFPAIINCV---LHTDDHAVMVAGGECLRSFINVSPEQICSYKNG-EGINC 731
            |.|    .|      .||::..:   |....:.:..|..:.:...:.|..:.|.|..|. :|.
Human   692 PVLWERTGN------IPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGF-- 748

  Fly   732 IMQVVATVLLNPMNSEMTAAGQIGRLVITIITKMGSMLGQNVDMLLKAV----ISKMQNLECLKV 792
                   .|||.:...|..                    ::||...|.:    ..::||.:..|.
Human   749 -------YLLNSIIEHMPP--------------------ESVDQYRKQIFILLFQRLQNSKTTKF 786

  Fly   793 IMNLVLIFAHLFLTQMDAVL---NFLSTVPGPNGE-------PAMQFVLTNWLSRQNSFFGNYER 847
            |.:. |:|.:|:..:..|:.   .|....|...|.       |.:|.|           .||.|:
Human   787 IKSF-LVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKV-----------SGNVEK 839

  Fly   848 KVTTMALCKLFEYGVATQDNRLTTITFKELVDDP--TDTRRRTRSVAATTQKWV-TIPALVKIFK 909
            |:..:.:.||                   |.:.|  .||.        .|:.|. .:.:|:.:|:
Human   840 KICAVGITKL-------------------LTECPPMMDTE--------YTKLWTPLLQSLIGLFE 877

  Fly   910 VLISEYQHFQEGKSDEPLTDSEEDGDDEDAPG 941
            :           ..|:.:.|.|...|.||.||
Human   878 L-----------PEDDTIPDEEHFIDIEDTPG 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	181/1013 (18%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	17/77 (22%)
CSE1L	NP_001307.2	IBN_N	29..102	CDD:197981	16/77 (21%)
		Cse1	156..526	CDD:369909	67/412 (16%)
		CAS_CSE1	527..962	CDD:367469	92/498 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810