DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and cse1l

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_012827002.1	Gene:	cse1l / 100158534	XenbaseID:	XB-GENE-5802331	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	1034	Identity:	186/1034 - (17%)
Similarity:	352/1034 - (34%)	Gaps:	251/1034 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVEN 79
            |.:.|.|:..|..|..|.:..||.::.:|..:.|.:.|..:: .::.:..::..:.|....|::.
Frog    45 QGLTEYLKKTLDPDPAVRRPAEKYLESVEGNQNYPLLLLTLV-ERSQDNVIKVCSAVTFKNYIKR 108

  Fly    80 HWTDDDDVKRKANGCMASEQA-KRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELF 143
            :|...:|  ...|.|.|...| |.:|.|::   |..| .:|:...:..||.|...|:|..|..|.
Frog   109 NWRIIED--EPNNICEADRIAIKSSIINLM---LSSP-EQIQKQFSDAISIIGREDFPQKWPNLL 167

  Fly   144 -DIIVKCLGGNEDSIHGAMQVL-------------QDFSYDVEQIKELGPVVIPEVYRIFDSEQN 194
             :::.:...|:...|:|.:...             .:...:::.:.:.....:.::::......|
Frog   168 TEMVNRFQSGDFHVINGVLHTAHSLFKRYRHEFKSSELWTEIKLVLDTFAAPLTDLFKATIELCN 232

  Fly   195 YSIKTRVSAIRILKPLFAS---IAALITNKEEQ------STMMSSILTNFMDKLM--HYLSMNSG 248
                |..:.:..||.||:|   ||.|..:...|      ...|.:.:|||.:.|.  :.|.....
Frog   233 ----THANDVNALKVLFSSLILIAKLFHSLNFQDLPEFFEDNMETWMTNFHNLLTLDNKLLQTDD 293

  Fly   249 AVSSFLLRTEIIKVFTHLVNEMPKY---INPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLA 310
            ...:.||.|...::..:......||   ..|::.|.:..:|.||                   :.
Frog   294 EEEAGLLETLKSQICDNAALYAQKYDEEFQPYLPRFVTAIWNLL-------------------VT 339

  Fly   311 SGDSEEDDEQTNFQSLIIQILEFINCILTCNKLRGSIKNVLADLIYITIV----------YIQLS 365
            :|      ::..:..|:...::|:..:  |.  |...||:..|...:|.:          :....
Frog   340 TG------QEVKYDLLVSNAIQFLASV--CE--RPHYKNLFEDPSTLTSICEKVIVPNMEFRAAD 394

  Fly   366 EEQLEDWHDDPEKFVDDEDDGGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEK 430
            ||..|   |:.|:::..:.:|....|.|....|::..:...|..    |:......:.|....|.
Frog   395 EEAFE---DNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEG----PVTNIFSGYVSSMLQEY 452

  Fly   431 AANNPNWWKIQEACMDAVHAFRDVILAGDSTFDLLNYLTIVRNLLVHQESPPLVGRALWTLSI-- 493
            |.:....||.::|.:..|.:...............|.|..:....|:...|.|....:....:
Frog   453 AKSPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNITEFFVNHILPDLKSANINEYPVLK 517

  Fly   494 --------YSKSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRTLNGFLQANETIDG-EKRTL 549
                    :.:|.|...|:|..| .:.:..|..| |.::...|...|..|.    |:.| ...||
Frog   518 ADGIKYIMFFRSQLPKEQLLVTI-PLLIAHLQAE-SVVVHTYAAHALERFF----TMKGATSPTL 576

  Fly   550 LVS------------------KLPG------FLDGIM--------ALVPGSKAAVLAL------- 575
            :|:                  .|||      .:..||        |::|...:.:..|
Frog   577 IVAAEMMPYVELLLANLFKALSLPGSSENEYIMKAIMRSFSLLQEAIIPYIPSVISQLTQKLLAV 641

  Fly   576 ------------LMEALTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLET-VQDLIKALC 627
                        |.||:...::....   |:.|.:.....|:||.:||   :|:: ||:.|..:.
Frog   642 SKNPSKPHFNHYLFEAICLSIRITCR---ANPAAVGSFEDALFLVFTE---ILQSDVQEFIPYVF 700

  Fly   628 QRKECLGPLQEKFIPTIVSILGLTGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINC 692
            |....|..:....|||  |.:.|....   .|.:..:....|     |||         ..::..
Frog   701 QVMSLLLEIHANDIPT--SYMALFPHL---LQPVLWERTGNI-----PPL---------VRLLQA 746

  Fly   693 VLHTDDHAVMVAGGECLRSFINVSPEQICSYKNG-EGINCIMQVVATVLLNPMNSEMTAAGQIGR 756
            .|....:.:..:..:.:...:.|..:.|.|..|. :|.         .|||.:...:.|
Frog   747 YLERGANTIAASASDKIPGLLGVFQKLIASKANDHQGF---------YLLNSIIEHLPA------ 796

  Fly   757 LVITIITKMGSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVL---NFLSTV 818
                      ..:.|....:...:..::|:.:..|.:.:. |:|.:||..:..|:.   .|.|..
Frog   797 ----------ECIEQYKRQIFIVLFQRLQSSKTTKFVKSF-LVFLNLFCIKFGAIALQEMFDSIQ 850

  Fly   819 PGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFKELVDDPTD 883
            |...|....:.:    :.......|..|:|:..:.|.|:.....|..|...|.:
Frog   851 PKMFGMVVEKII----IPEIQKVSGPIEKKICAVGLTKVLTECPAMMDTEYTKL----------- 900

  Fly   884 TRRRTRSVAATTQKWV-TIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDDEDAPG 941
                          |. .:.||:.:|::           ..|:.:.|.|...|.||.||
Frog   901 --------------WTPLLQALIGLFEL-----------PEDDTIPDDEHFIDIEDTPG 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	174/981 (18%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	17/78 (22%)
cse1l	XP_012827002.1	IBN_N	65..138	CDD:197981	16/78 (21%)
		Cse1	192..562	CDD:369909	68/411 (17%)
		CAS_CSE1	563..998	CDD:367469	82/467 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910