DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp9 and ipo9

DIOPT Version :9

Sequence 1:	NP_001287284.1	Gene:	Ranbp9 / 41367	FlyBaseID:	FBgn0037894	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001090647.1	Gene:	ipo9 / 100036619	XenbaseID:	XB-GENE-5960761	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1053	Identity:	389/1053 - (36%)
Similarity:	612/1053 - (58%)	Gaps:	89/1053 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYV 77
            :::|:::.|..:||....|....|:::|.||.||.:||:|:|:.::....|.:||:|.|:|.:||
Frog    16 LREALLDTLNGILSPGHEVRAAAEEQLKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYV 80

  Fly    78 ENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAEL 142
            ||||....:..|...   .:|:||..||.:||.||.:..||:|||||:.:|.||..|:|..|.:|
Frog    81 ENHWCSQSEKFRLPE---TTERAKTAIRQLLPTGLRESISKVRSSVAYAVSAIAHWDWPEAWPQL 142

  Fly   143 FDIIVKCL-GGNEDSIHGAMQVLQDFSYDV--EQIKELGPVVIPEVYRIFDSEQNYSIKTRVSAI 204
            |:|:::.| .|..:::||||:||.:|:.:|  .|:..:.||::||:|:||...:.|.|:||..|:
Frog   143 FNILMEMLVSGEVNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMSEVYGIRTRSRAV 207

  Fly   205 RILKPLFASIAALITNKEE-----QSTMMSSILTNFMDKLMHYLSMNSGAVSSFLLRTEIIKVFT 264
            .|    |.:.|.:|...||     ...::..::..|.:..:..|.|..|..|...|:.|::|..|
Frog   208 EI----FTTCAHMICTMEELEKGVAHALIFPVVQQFTEAFVQALQMPDGPTSDSGLKMEVLKAVT 268

  Fly   265 HLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTE--TSPLASGDSEEDDEQTNFQSLI 327
            .||...||::...|.::|||||..||:.|..||:..||.||  ..|:     :.|.|...|::|:
Frog   269 ALVKNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNDTEDIEDPV-----DSDGEVLGFENLV 328

  Fly   328 IQILEFINCILTCNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVELTV 392
            ..|.||::.:|. :|.:|::|..|.:|||..|:|:|::|||::.|..:|::||:||||.....||
Frog   329 FSIFEFVHTLLD-SKFKGTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTV 392

  Fly   393 RMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFRDVILA 457
            |:..:|:|||::.||...:...|..|..||...|:..||....:||||.||||.|:.:.:.||..
Frog   393 RIAAQDLLLAVSSEFQNESAVALAAAATRHLQEAEQYKAQGGEHWWKIHEACMLALGSVKSVITE 457

  Fly   458 GDST----FDLLNYLTIV----RNLLVHQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLC 514
            |..:    ||:..:||.|    .||.|   ||.|:||:||..|.::.:  .:|:::.:.|..|:.
Frog   458 GVQSGRVQFDMHGFLTGVILSDLNLSV---SPFLLGRSLWAASRFTAA--MSPELIQQFLQATVS 517

  Fly   515 SLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEA 579
            .|...:...:||||||.:.|:  .::....|...:|...||..|||::.|.....:.||.|:||.
Frog   518 GLHDNQPPSVRISAVRAIWGY--CDQLKISESTHVLQPFLPSVLDGLIHLAAQFTSEVLNLVMET 580

  Fly   580 LTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTI 644
            |..:...|..|..:::|||.|..||:||||:.||.|....||:.|.|.|...|...:|.:.|||:
Frog   581 LCIVCSVDPAFTASAEAKICPFTIAIFLKYSNDPVVASLAQDIFKELAQIPGCQNAMQMRLIPTL 645

  Fly   645 VSILGL------TGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINCVLHTDDHAVMV 703
            |||:..      :|..:|     |:|:|.|:||.|:|||:..|:..||||:..|.|..||:.:|.
Frog   646 VSIMQAPAEKIPSGLCAT-----AIDILTTVVRNTKPPLSELLICQAFPAVAQCTLRADDNTIMQ 705

  Fly   704 AGGECLRSFINVSPEQICSYKNGE---GINCIMQVVATVLLNPMNSEMTAAGQIGRLVITIITKM 765
            .||||||::::|:.||:..:::.:   |:..:||||:. ||:|..||.||| .:||||.|:|:|.
Frog   706 NGGECLRAYVSVALEQVAQWRDEQGHTGLWYVMQVVSQ-LLDPRTSEFTAA-FVGRLVSTLISKA 768

  Fly   766 GSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVLNFLSTVPGPNGEPAMQFV 830
            |..||:|:|.:|:|::||||..|.|.|:.:|:::||||..:|::.:|.||.::|||.|:||::||
Frog   769 GRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHSQLEPLLEFLCSLPGPTGKPALEFV 833

  Fly   831 LTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFK--ELVDDPTDTRRRTRSVAA 893
            ::.|:|||:.|:|.||.||:::||||:.:||:...|.||..|..|  |:.:.....|.|::: :.
Frog   834 MSEWMSRQHLFYGQYEGKVSSVALCKILQYGITVDDKRLQDIKVKGDEIFNMEEGIRTRSKT-SR 897

  Fly   894 TTQKWVTIPALVKIFKVLISEY--------------QHFQEGKSDEPLTDSEEDGDDED--APGN 942
            ..:.|.|||.|||::|::|:|.              :..|...:|:| .|..||.|:||  ..|
Frog   898 NPECWTTIPLLVKMYKLIINELSTVIEANATRNTEDEWIQGNGADDP-NDMWEDEDEEDEGLAG- 960

  Fly   943 PDKPRYISDLFESD-------EDNAEDEQLLQELLKETNYQGDIADNLQKFLTTFTQNEHFPTFY 1000
                :.:||:..|:       ||:.||:   .::||:..||.|:...|..||..|.|...|..|.
Frog   961 ----QLLSDILSSNKYDDDYYEDDEEDD---PDVLKDPLYQIDLQTYLTDFLRQFAQQPCFSAFS 1018

  Fly  1001 EHLTEGERLILLS 1013
            |||.:.||..|.|
Frog  1019 EHLNDNERRTLQS 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp9	NP_001287284.1	SXM1	14..891	CDD:227943	343/905 (38%)
Ranbp9	NP_001287284.1	IBN_N	36..114	CDD:281761	32/77 (42%)
ipo9	NP_001090647.1	CSE1	29..806	CDD:227944	302/803 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	574	1.000	Domainoid score	I224
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5874
Inparanoid	1	1.050	640	1.000	Inparanoid score	I808
OMA	1	1.010	-	-		QHG55070
OrthoDB	1	1.010	-	-		D364997at33208
OrthoFinder	1	1.000	-	-		FOG0005540
OrthoInspector	1	1.000	-	-		oto105243
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R604
SonicParanoid	1	1.000	-	-		X4496
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110