Protein Alignment Blm and SGS1

DIOPT Version :10

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: NP_013915.1
• Gene: SGS1 / 855228
• SGDID: S000004802
• Length: 1447
• Species: Saccharomyces cerevisiae
• Alignment Length: 1525
• Identity: 411/1525 - (26%)
• Similarity: 655/1525 - (42%)
• Gaps: 320/1525 - (20%)

  Fly   169 QKERKTSIVWLSDSPE------------KKVTQNERKILDSPLQRFSFEDFPNKEN---GNRHHL 218
            ::|.|    ||.::..            :|...|:|...:||      ...|:|:.   |..:.:
Yeast    10 RREHK----WLKETATLQEDKDFVFQAIQKHIANKRPKTNSP------PTTPSKDECGPGTTNFI 64

  Fly   219 LTLPDSPPPPQPVKKPE-------KTMWQNETKTIQDKDSPANPLVSNNLASI--------STLL 268
            .::|.|.|.....|:.|       .|.|.:.|.|            ||..|.:        ::::
Yeast    65 TSIPASGPTNTATKQHEVMQTLSNDTEWLSYTAT------------SNQYADVPMVDIPASTSVV 117

  Fly   269 DSSRAPNTYKGSSRNLF----------EDSPEKSGSGE------QGYKLGSAKENEIPTKPATAS 317
            .:.|.||..|..:.|.|          .||....||..      ....:|...||:|  |.....
Yeast   118 SNPRTPNGSKTHNFNTFRPHMASSLVENDSSRNLGSRNNNKSVIDNSSIGKQLENDI--KLEVIR 180

  Fly   318 LERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDL-------AQNDNFSIDPNKQNTETLKSTLG 375
            |:.:.:.:....:..|..:.|:....||::..|.|       .|..|.||..:....|.:|:.
Yeast   181 LQGSLIMALKEQSKLLLQKCSIIESTSLSEDAKRLQLSRDIRPQLSNMSIRIDSLEKEIIKAK-- 243

  Fly   376 FFRNTYVELMEKYCSL-IDQIPAMHFNEIAGFQP----------NTFLKLKVMRQKFKA-----R 424
                  .:.|.|..|. ..|:.:...|.|:...|          |:.|.........||     .
Yeast   244 ------KDGMSKDQSKGRSQVSSQDDNIISSILPSPLEYNTSSRNSNLTSTTATTVTKALAITGA 302

  Fly   425 TQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMP-LPKVQEIKDEKI 488
            .|.:.|:..|..:......:.::..:.|...:.....:|...:|..  |..| |....|.:||..
Yeast   303 KQNITNNTGKNSNNDSNNDDLIQVLDDEDDIDCDPPVILKEGAPHS--PAFPHLHMTSEEQDELT 365

  Fly   489 PNRNQLIHDLCGEPDNFSPPSSPRDTQLIPKRQQLINDLCGEP--DDFSPPSKQNDPHLLRKCEE 551
            ..||....    ||.|:.          ||.|....:.:.|:.  ||: |..::.:..|..:.|:
Yeast   366 RRRNMRSR----EPVNYR----------IPDRDDPFDYVMGKSLRDDY-PDVEREEDELTMEAED 415

  Fly   552 LVH-------DLCEEPDDYLAQS---------------------MMLDGDLEEEQLNGPTQGTTT 588
            ..|       |..:|.::.|.||                     |.:..:::|....|.|:.|.|
Yeast   416 DAHSSYMTTRDEEKEENELLNQSDFDFVVNDDLDPTQDTDYHDNMDVSANIQESSQEGDTRSTIT 480

  Fly   589 SGMDDD-----------------------------EDDLEGLLAEIEDEHQKMQGRRSEFNGYSY 624
            ...:.:                             ||||| ..|.::|......||  :....|:
Yeast   481 LSQNKNVQVILSSPTAQSVPSNGQNQIGVEHIDLLEDDLE-KDAILDDSMSFSFGR--QHMPMSH 542

  Fly   625 KELEAV---KVKEKHKETPINIS---LDDDGFPEYDE--------AMFEQMHSQAAANKSRVSSA 675
            .:||.:   |..|..:|...|..   |.|.....:||        |..:::.:.......|..:.
Yeast   543 SDLELIDSEKENEDFEEDNNNNGIEYLSDSDLERFDEERENRTQVADIQELDNDLKIITERKLTG 607

  Fly   676 G-----PSTSKSVVPTKQTSALHSQK-----LSGNFHAN--VHNDGITGEFDGQKFEHSTRLMHG 728
            .     ||.|..:   |:..:..|||     ...:|..:  |....::.:.:|..:..|..:::.
Yeast   608 DNEHPPPSWSPKI---KREKSSVSQKDEEDDFDDDFSLSDIVSKSNLSSKTNGPTYPWSDEVLYR 669

  Fly   729 LSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAIL----TEGVTIVISPLKSL 789
            |...|.|..||||||:.:||||.|.|.||||||||||||||||||::    |.|.|||||||.||
Yeast   670 LHEVFKLPGFRPNQLEAVNATLQGKDVFVLMPTGGGKSLCYQLPAVVKSGKTHGTTIVISPLISL 734

  Fly   790 IFDQINKLASLDICAKSLS----GEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTL 850
            :.||:..|.:.:|.|...|    .||:..........|      :.|:|::||.||:|.:.:..:
Yeast   735 MQDQVEHLLNKNIKASMFSSRGTAEQRRQTFNLFINGL------LDLVYISPEMISASEQCKRAI 793

  Fly   851 DTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQL 915
            ..|.::..::|.|:|||||||.||||||||||:|...|:.:|::|.|||||||:.:||:||:..|
Yeast   794 SRLYADGKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMIALTATASEQVRMDIIHNL 858

  Fly   916 NLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDETSKKMCK 980
            .||...:...||||:||.|.| .||..:|:.:|...::|:.::.:|||||.|:|.|::||.:|.:
Yeast   859 ELKEPVFLKQSFNRTNLYYEV-NKKTKNTIFEICDAVKSRFKNQTGIIYCHSKKSCEQTSAQMQR 922

  Fly   981 DGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQE 1045
            :|::...||||:...:|.|.||.|...:::||||||||||||||||||||.|:::|:::||||||
Yeast   923 NGIKCAYYHAGMEPDERLSVQKAWQADEIQVICATVAFGMGIDKPDVRFVYHFTVPRTLEGYYQE 987

  Fly  1046 AGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRAQQ 1110
            .|||||||:.:.||.|:::.|:..::.|:..||.|....|:.|::.|.:::.||:|:|||||...
Yeast   988 TGRAGRDGNYSYCITYFSFRDIRTMQTMIQKDKNLDRENKEKHLNKLQQVMAYCDNVTDCRRKLV 1052

  Fly  1111 LDYFGEHFTSEQCLENRETACDNC------INKRAYKAVDALEHARKAARAVKDLCSGRSRFTLL 1169
            |.||.|.|.|:.|.:|    ||||      ||:..    |..|.|:|..:.|:.:  ...|.|::
Yeast  1053 LSYFNEDFDSKLCHKN----CDNCRNSANVINEER----DVTEPAKKIVKLVESI--QNERVTII 1107

  Fly  1170 HIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLREDLIFTND-FPQAYL 1233
            :..||.|||:..||:..||.....||:.|...|:::.|:...::....|:|..|..|. |..:|:
Yeast  1108 YCQDVFKGSRSSKIVQANHDTLEEHGIGKSMQKSEIERIFFHLITIRVLQEYSIMNNSGFASSYV 1172

  Fly  1234 YLGNNISKLMEGTPNFEFAVTKNAKEAKAAV---------------------------------- 1264
            .:|.|..||:.|....:...|.:|..::.:.
Yeast  1173 KVGPNAKKLLTGKMEIKMQFTISAPNSRPSTSSSFQANEDNIPVIAQKSTTIGGNVAANPPRFIS 1237

  Fly  1265 -----------GSVSDGATSSTADGQSGMREIHE-----RCYTDLLDLCRTIASQRNVTMASIMN 1313
                       ||....:...|....|.:|...|     ..|..|.:|...:.::....:.:.|.
Yeast  1238 AKEHLRSYTYGGSTMGSSHPITLKNTSDLRSTQELNNLRMTYERLRELSLNLGNRMVPPVGNFMP 1302

  Fly  1314 IQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQ 1378
            ...||.||..||:.:....::..|.    |||..:.          |.....:.|..:::::...
Yeast  1303 DSILKKMAAILPMNDSAFATLGTVE----DKYRRRF----------KYFKATIADLSKKRSSEDH 1353

  Fly  1379 RPSTSGWNNESVDWDMAVASQGNANTSGAS----GFNSFRAGKRKKIYKSGASKRYKTSTTSPAA 1439
            ....:..|:|.|: ..|.:|.|.|.::|..    |.|...|.:.::|.......:...:|||..:
Yeast  1354 EKYDTILNDEFVN-RAAASSNGIAQSTGTKSKFFGANLNEAKENEQIINQIRQSQLPKNTTSSKS 1417

  Fly  1440 RKTTSARGRGGRAGAKRAESSASSASGWKS 1469
                     |.|:.:|.::.||:...|:::
Yeast  1418 ---------GTRSISKSSKKSANGRRGFRN 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RecQ	733..1217	CDD:440280	220/497 (44%)
		HRDC	1283..1357	CDD:470625	16/78 (21%)
SGS1	NP_013915.1	RecQ	670..1151	CDD:440280	221/497 (44%)
		Helicase_Sgs1	1271..1350	CDD:463270	17/92 (18%)