DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and RECQ4A

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_172562.2	Gene:	RECQ4A / 837636	AraportID:	AT1G10930	Length:	1188	Species:	Arabidopsis thaliana

Alignment Length:	1267	Identity:	375/1267 - (29%)
Similarity:	569/1267 - (44%)	Gaps:	246/1267 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 NKENGNRHHLLTLPDSPPPPQPVKKPEKTMWQNETKTIQDKDSPANPLVSNNLASISTLLDSSRA 273
            |....:|.|   ||:...|..|     :|.|....|.::...|....|.||.|.::.:......|
plant     3 NSNQMSRSH---LPEVQKPRGP-----QTNWSEHAKALESSSSVTKFLSSNVLYALESQKPRDMA 59

  Fly   274 PNTYKGSSRNLFE-DSPEKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRY 337
            ..:....|.|:.. ..|:.|.:..                 |.:||..|:....|....|:
plant    60 ARSIAFPSVNVHTLAHPQISKAWR-----------------ALSSLSVNNTYLRPGVTPPI---- 103

  Fly   338 SVAFDNSLADYLKDLAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMH--- 399
                         |:..||::|. ..:...:.:.||.|          ..|.|....:.||:
plant   104 -------------DVGTNDSYSA-RERSTAKVISSTGG----------SVYSSTRPNLSAMNVSG 144

  Fly   400 ----FNEIAGFQPNTFLKLKVMRQKFKARTQLVQ---------NSLDKK--ESQLKAEQ------ 443
                |:......|...   |::.:||......::         |.::|.  .|...|||
plant   145 TGRSFHSFPSSVPGDD---KIVAEKFPRGNNEIRESEPSCTHLNGVEKSFGNSAFPAEQFESRKA 206

  Fly   444 --EALEKEEIEMQAEQAQQTVL----SSSSPEKSRPIMPLPKVQEIKDEKIPNRNQLIHDLCGEP 502
              :.::.::| ::.....|.|:    |:|:|:        |.|
plant   207 CLDDMDDDDI-LENIDVDQIVMEHYHSTSTPQ--------PSV---------------------- 240

  Fly   503 DNFSPPSSPRDTQLIPKRQQLINDLCGEPDDFSPPSKQNDPHLLRKCEELVH-DLCEEPDDYLAQ 566
            .|||..:.|.|     :....:.:.|..|           |.|...|...:. .||.|...::.|
plant   241 SNFSLRTPPVD-----RSASRLEEECNLP-----------PELCSNCSHGIKLGLCPEASTHVEQ 289

  Fly   567 ---------SMMLD----------GDLEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKM 612
                     :.:||          |.|.:|:|.                 |:..:.::|:..:..
plant   290 MKDVLLAISNELLDDATDLSPDRVGQLRQERLR-----------------LKKQIQQLENHIRDK 337

  Fly   613 QGRRSEFNG------YSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSR 671
            :.::|:|..      :.|:..::...|....:|.....:.|.|....| :......|..:.::..
plant   338 ESQKSQFLSSTATRIFQYETPKSTNYKMDQPQTDFRAHVSDQGRYACD-SWNTPRDSSFSVDRYG 401

  Fly   672 VSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQKFEHSTRLMHGLSYSFGLK 736
            :||| |...:..||          |:....:....||   .::..::|..:.:|.......||..
plant   402 LSSA-PVEREQYVP----------KIIDVTYTEGSND---KKWSSREFPWTRKLEVNNKKVFGNH 452

  Fly   737 SFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLASLD 801
            ||||||.::||||:.|:|.||||||||||||.|||||::..|:|:|||||.|||.|||..|...:
plant   453 SFRPNQREIINATMSGSDVFVLMPTGGGKSLTYQLPALICGGITLVISPLVSLIQDQIMNLLQAN 517

  Fly   802 ICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDE 866
            |.|.|||...:.|:.:.|:::|.|:....|||||||||::.|......|:.|||...::||||||
plant   518 IPAASLSAGMEWAEQLKIFQELNSEHSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDE 582

  Fly   867 AHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSN 931
            |||||||||||||||:.||:||::|||:|.:|||||||..|:.|::..|.|.||..|..||||.|
plant   583 AHCVSQWGHDFRPDYQSLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPN 647

  Fly   932 LRYRVLPKKGVSTLDDISRYIRSKPQHFS--GIIYCLSRKECDETSKKMCKDGVRAVSYHAGLTD 994
            |.|.|:||. ...|:||.::|  |..||.  ||||||||.:|::.|:::.:.|.:|..||..:..
plant   648 LWYSVVPKT-KKCLEDIDKFI--KENHFDECGIIYCLSRMDCEKVSERLQEFGHKAAFYHGSMEP 709

  Fly   995 TDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCI 1059
            ..|...|..|...::.:|||||||||||:|||||||:|:|||||||||:||.|||||||..:.|:
plant   710 EQRAFIQTQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCV 774

  Fly  1060 LYYNYSDMLRIKKML------DSDKALQYN-------VKKIHVDNLYRIVGYCENLTDCRRAQQL 1111
            |||.|.|.:|:|.|:      .|..|..||       :.:.:.:||.|:|.||||..:|||..||
plant   775 LYYGYGDYIRVKHMISQGGVDQSPMATGYNRVASSGRLLETNTENLLRMVRYCENEVECRRFLQL 839

  Fly  1112 DYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSGRSRFTLLHIADVLK 1176
            .:.||.|.|..|    :..||||.:.::....|.....|:....||.  :| .||:..||.:|.:
plant   840 VHLGEKFDSTNC----KKTCDNCCSSQSLIDKDVTLITRQLVELVKQ--TG-ERFSSAHILEVYR 897

  Fly  1177 GSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLRED------------LIFTNDFP 1229
            ||..:.:....|.....||..|...|.:|.|:|..:|.:..|.||            |:..|:..
plant   898 GSLNQMVKKHRHETLQFHGAGKHLSKIEVSRILHYLVTEDILVEDVRKSDMYGSVSSLLQVNNAK 962

  Fly  1230 QAYLYLGNNISKLMEGTPNFEFAVTKNAKE-AKAAVGSVSDGATS----STADGQSGMREIHERC 1289
            ...|:.|:  ..::...|: ...|.|.:|: |.||.|.::....|    :|.|.......:....
plant   963 ATILFSGS--QTIVMKFPS-SVKVLKPSKQGATAAKGPLTSEKQSTLPLTTEDAPPKDVNLSANM 1024

  Fly  1290 YTDLLDLCRTIASQR--NVTMASIMNIQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLE- 1351
            ||.|..|...:..:.  .|....|.....|:.::..:|.|::::..|..:.||...|||.:|||
plant  1025 YTALRKLRTALVKEAPDGVMAYHIFINSTLQQISRRIPRTKEELLEINGLGKAKVSKYGDQLLET 1089

  Fly  1352 ----ITSNYASEKLLMQAVLDEEEEQAAAKQR 1379
                :...|.:.|  ..:::..:...:..::|
plant  1090 IETTVNEYYGTNK--KDSIISNDSPDSGKRRR 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	29/124 (23%)
		HRDC	1286..1352	CDD:278967	18/72 (25%)
		RecQ	729..1359	CDD:223588	275/668 (41%)
		DEAD	739..908	CDD:278688	100/168 (60%)
		HELICc	931..1061	CDD:238034	68/131 (52%)
		RecQ_Zn_bind	1066..1134	CDD:292742	28/80 (35%)
RECQ4A	NP_172562.2	PLN03137	1..1188	CDD:215597	375/1267 (30%)
		DEAD	455..625	CDD:278688	101/169 (60%)
		HELICc	650..776	CDD:238034	66/128 (52%)
		RecQ_Zn_bind	781..858	CDD:292742	28/80 (35%)
		RQC	868..966	CDD:214936	26/100 (26%)
		Sec_Non_Glob	955..>1023	CDD:275213	15/70 (21%)
		HRDC	1025..1090	CDD:278967	18/64 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	204	1.000	Domainoid score	I835
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I370
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	1	1.000	-	-		FOG0001239
OrthoInspector	1	1.000	-	-		otm2997
orthoMCL	1	0.900	-	-		OOG6_100352
Panther	1	1.100	-	-	O	PTHR13710
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870