DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and RECQSIM

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001330792.1	Gene:	RECQSIM / 832830	AraportID:	AT5G27680	Length:	858	Species:	Arabidopsis thaliana

Alignment Length:	992	Identity:	242/992 - (24%)
Similarity:	367/992 - (36%)	Gaps:	378/992 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 AAANKSRVSSAGPSTSKSVVPTKQTSAL------HSQKLSGNFHANVHNDGITGEFDGQ---KFE 720
            :.:||.....|.||:..|....:|:|.|      :..|..|:....|       |.|.|   ..|
plant    60 SGSNKILGKRAMPSSFSSSESKRQSSLLDHFRSVNQNKKKGDTFGTV-------EVDSQLETVSE 117

  Fly   721 HST-------------------RLMHGLSYS---------------FGLKSFRPNQLQVINATLL 751
            ||.                   :|::|.|.:               ||:.|.|..|.:.::..:.
plant   118 HSEEVRKSLAPVFMESSCFPEGQLLNGCSEASSSWEKRVNSILRNRFGISSLRSFQREALSTWVA 182

  Fly   752 GNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLA------------SLDIC- 803
            ..||.||..||.|||||:|:||:||..|.:|||||.||:.||..||:            .||.|
plant   183 HKDCLVLAATGSGKSLCFQIPALLTGKVVVVISPLISLMHDQCLKLSRHKVSACFLGSGQLDNCI 247

  Fly   804 -AKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEA 867
             .|::.|                   |.:::||.||.:   .|....|..|...:.|:.|.||||
plant   248 EEKAMQG-------------------MYQIIYVCPETV---VRLIKPLQKLAKTHGIALFAIDEA 290

  Fly   868 HCVSQWGHDFRPDYKKLGVLKKRF---------PNVPTIALTATATPRVRLDILAQLNL-KNCKW 922
            ||||:|||||||.|:||.||::.|         .:||.:|||||||..|:.|||..|:| |..|.
plant   291 HCVSKWGHDFRPHYRKLSVLRENFCASNLEFLEYDVPIMALTATATVNVQEDILESLHLSKETKI 355

  Fly   923 FLSSFNRSNLRYRV--------------------------------------------------- 936
            .|:||.|.||::.|
plant   356 VLTSFFRPNLQFSVKHSRTKFASSYAKDFQNLVDLYSEKKNSTGKKLAVISRESEEQTDFGSHDS 420

  Fly   937 ------------------LPKKGVSTLDDISR-YIRSKPQHFSG--------------------- 961
                              |.||..|...::|. |:..:...|..
plant   421 ENIHETDYDEDEEDQENSLAKKNSSNGKELSEAYLEDETDIFQSVDDWDVACGEFCAMPSCELLE 485

  Fly   962 ---------------IIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRV 1011
                           |||..:|||....:|.:|..|::|.:|:|.|.........:|:...|::|
plant   486 IPVPSEKQKDLEGLTIIYVPTRKESVNIAKYLCGVGLKAAAYNASLPKKHLRQVHQDFHDNKLQV 550

  Fly  1012 ICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDS 1076
            :.||:||||||||.:||.::||...:|:|.||||||||||||::|:|:|   |:|:.|...:|.|
plant   551 VVATIAFGMGIDKKNVRKIIHYGWLQSLEAYYQEAGRAGRDGELAECVL---YADLSRAPTLLPS 612

  Fly  1077 DKALQYNVKKIHVDNLYRIVGYC----ENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINK 1137
            .::      |...:..|:::..|    .|.:.||....::||||.|:|::|     .:||.| .:
plant   613 RRS------KEQTEQAYKMLSDCFRYGMNTSQCRAKILVEYFGEEFSSKKC-----NSCDVC-TE 665

  Fly  1138 RAYKAVDALEHARKAARAVKDLCSGRSRFTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDK 1202
            ...:.||..|.|....:.:          |..|:.           :|.:....|:    :|:.
plant   666 GPPELVDVREEANLLFQVI----------TAFHLQ-----------VDNDSEHAPY----EDYG- 704

  Fly  1203 NDVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSV 1267
                                            |||:....:...||..|.::|
plant   705 --------------------------------LGNSKQNKLSHKPNLLFFISK------------ 725

  Fly  1268 SDGATSSTADGQSGMREIHERC----YTDLL---DLCRTIASQRNVTMASIMNIQALKSMAETLP 1325
                             :.|:|    .||.|   .|.|.:.::..:   ..|:.:..:...:.:.
plant   726 -----------------LREQCEKFKETDCLWWKGLARIMEAEGYI---KEMDNKDRRVEIKFIQ 770

  Fly  1326 ITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESV 1390
            .|||                |.|.|:    :..:|.|.  |..|.:...:.||..:.||::....
plant   771 PTEK----------------GKKQLD----FQDDKPLY--VYPEADMLLSLKQDRTYSGFSEWGK 813

  Fly  1391 DW-DMAVASQGNANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAARKTTSARGRGGRAGA 1454
            .| |..:..|              |..:|         :|.......|..::|   |||
plant   814 GWADPEIRRQ--------------RLERR---------ERKPRRERKPRKKRT---RGR------ 846

  Fly  1455 KRAESSASSASGWKSKK 1471
                 |::....|:||:
plant   847 -----SSTKLHPWRSKE 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	15/112 (13%)
		HRDC	1286..1352	CDD:278967	14/72 (19%)
		RecQ	729..1359	CDD:223588	199/785 (25%)
		DEAD	739..908	CDD:278688	75/191 (39%)
		HELICc	931..1061	CDD:238034	56/235 (24%)
		RecQ_Zn_bind	1066..1134	CDD:292742	19/71 (27%)
RECQSIM	NP_001330792.1	UBA_like_SF	8..42	CDD:304366
		DEXDc	162..355	CDD:214692	85/214 (40%)
		DEAD	170..341	CDD:278688	76/192 (40%)
		HELICc	486..600	CDD:238034	47/116 (41%)
		RecQ_Zn_bind	612..663	CDD:292742	16/61 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820