Sequence 1: | NP_524319.2 | Gene: | Blm / 41366 | FlyBaseID: | FBgn0002906 | Length: | 1487 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_000544.2 | Gene: | WRN / 7486 | HGNCID: | 12791 | Length: | 1432 | Species: | Homo sapiens |
Alignment Length: | 1119 | Identity: | 284/1119 - (25%) |
---|---|---|---|
Similarity: | 468/1119 - (41%) | Gaps: | 253/1119 - (22%) |
- Green bases have known domain annotations that are detailed below.
Fly 419 QKFKARTQ-----LVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLP 478
Fly 479 KVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPK---------RQQLINDLCGEPDDF 534
Fly 535 SPPSKQN------------DPHLLRKCEELVH--DLCEEPD-DYLAQSMMLDGD----------- 573
Fly 574 ------LEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKV 632
Fly 633 KEKHKETPINISLDDD-------------------GFPEYDEAM-FEQMHSQAAANKSRVSSAGP 677
Fly 678 STSKSV-------VPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQK--------FEHSTRLMH 727
Fly 728 GLSYSFGLKSFRPNQLQVINATL-LGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIF 791
Fly 792 DQI--NKLASLDIC-AKSLSGEQKMADV-MAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDT 852
Fly 853 LNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLNL 917
Fly 918 KNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQH--FSG--IIYCLSRKECDETSKKM 978
Fly 979 CKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYY 1043
Fly 1044 QEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRA 1108
Fly 1109 QQLDYFGEHFTSEQCL--ENRETACDNCINK--RAYKAVDALEHARKAARAVKDLCSGRSRFTLL 1169
Fly 1170 HIADV-------------LKGSKIKKIID-FNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLRE 1220
Fly 1221 DLIFTNDFPQA---------YLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTA 1276
Fly 1277 DGQSGMREIHERCYTDL-LDL----------------CRTIASQRNVTMASIMNIQALKSMAETL 1324
Fly 1325 PITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQA-AAKQRPSTSGWNNE 1388
Fly 1389 SVDWDMAVASQGNA 1402 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Blm | NP_524319.2 | RQC | 1140..1253 | CDD:286470 | 27/135 (20%) |
HRDC | 1286..1352 | CDD:278967 | 17/82 (21%) | ||
RecQ | 729..1359 | CDD:223588 | 198/682 (29%) | ||
DEAD | 739..908 | CDD:278688 | 67/173 (39%) | ||
HELICc | 931..1061 | CDD:238034 | 52/133 (39%) | ||
RecQ_Zn_bind | 1066..1134 | CDD:292742 | 13/69 (19%) | ||
WRN | NP_000544.2 | Interaction with WRNIP1. /evidence=ECO:0000250 | 2..277 | 21/95 (22%) | |
RNaseD_like | 61..229 | CDD:176650 | 5/19 (26%) | ||
2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K | 424..477 | 8/52 (15%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 498..529 | 8/42 (19%) | |||
recQ_fam | 538..1010 | CDD:129701 | 163/503 (32%) | ||
DEAD | 551..712 | CDD:278688 | 67/173 (39%) | ||
DEAH box | 668..671 | 2/2 (100%) | |||
HELICc | 759..867 | CDD:238034 | 45/107 (42%) | ||
RecQ_Zn_bind | 872..939 | CDD:292742 | 13/69 (19%) | ||
RQC | 958..1051 | CDD:214936 | 20/104 (19%) | ||
Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463 | 987..993 | 2/5 (40%) | |||
HRDC | 1156..1229 | CDD:128635 | 18/60 (30%) | ||
HTH_40 | 1261..1351 | CDD:291179 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG0514 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D445763at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |