DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Blm and WRN

DIOPT Version :9

Sequence 1:NP_524319.2 Gene:Blm / 41366 FlyBaseID:FBgn0002906 Length:1487 Species:Drosophila melanogaster
Sequence 2:NP_000544.2 Gene:WRN / 7486 HGNCID:12791 Length:1432 Species:Homo sapiens


Alignment Length:1119 Identity:284/1119 - (25%)
Similarity:468/1119 - (41%) Gaps:253/1119 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   419 QKFKARTQ-----LVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLP 478
            ||..|.|.     ::..:|:..:..:  ::.|:.|||..:.::..:|  |:|.|.|    :|.|.
Human   209 QKLYAATDAYAGFIIYRNLEILDDTV--QRFAINKEEEILLSDMNKQ--LTSISEE----VMDLA 265

  Fly   479 KVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPK---------RQQLINDLCGEPDDF 534
            |                |    .|..||...:||...::.|         |:.:|.....| .:.
Human   266 K----------------H----LPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIE-TEL 309

  Fly   535 SPPSKQN------------DPHLLRKCEELVH--DLCEEPD-DYLAQSMMLDGD----------- 573
            .|.:..|            ....:|:.|.|:|  |...:|. |:||:.   ||:           
Human   310 RPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKH---DGEDVLGNKVERKE 371

  Fly   574 ------LEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKV 632
                  :|:.:|....:......:|..|.:|:.|..:.::|:         .:..:||..|.:..
Human   372 DGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEY---------LSDIAYKSTEHLSP 427

  Fly   633 KEKHKETPINISLDDD-------------------GFPEYDEAM-FEQMHSQAAANKSRVSSAGP 677
            .:...:|...|..|:|                   ...|.||.: .|.:.|....|...|.   |
Human   428 NDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVE---P 489

  Fly   678 STSKSV-------VPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQK--------FEHSTRLMH 727
            :.||.:       :|||:.            ..:..|:...||.|..|        .|..|    
Human   490 THSKCLKMERNLGLPTKEE------------EEDDENEANEGEEDDDKDFLWPAPNEEQVT---- 538

  Fly   728 GLSYSFGLKSFRPNQLQVINATL-LGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIF 791
            .|...||..||:|.|.:||::.| ...|...:|.||.|||||:|.|.:....:.:|||||.||:.
Human   539 CLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLME 603

  Fly   792 DQI--NKLASLDIC-AKSLSGEQKMADV-MAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDT 852
            ||:  .|::::..| ..|...|..:.|: :..||          ::|||||..|.:   ...|..
Human   604 DQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYR----------IVYVTPEYCSGN---MGLLQQ 655

  Fly   853 LNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLNL 917
            |.::..|:...:|||||:|:||||||..::|||.||...|.||.:||||||:..:|.||:..|||
Human   656 LEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL 720

  Fly   918 KNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQH--FSG--IIYCLSRKECDETSKKM 978
            :|.:...:.|:|.||...|..|.| :.|.|:..::.....|  |.|  ||||.|||...:.:.::
Human   721 RNPQITCTGFDRPNLYLEVRRKTG-NILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGEL 784

  Fly   979 CKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYY 1043
            .|..:...:||||::.:.|:.....::..:::.:.||:||||||:|.|:|.|:||..||.:|.||
Human   785 RKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYY 849

  Fly  1044 QEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRA 1108
            ||.|||||||..:.|.:.:..:|:...:.:|...:..::.:.|:.:  :.::..|..: :.|||.
Human   850 QEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKM--MAKMEKYLHS-SRCRRQ 911

  Fly  1109 QQLDYFGEHFTSEQCL--ENRETACDNCINK--RAYKAVDALEHARKAARAVKDLCSGRSRFTLL 1169
            ..|.:|.:....:..|  ...|..||||.::  ..|...|:.:.:..         .|...|.||
Human   912 IILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWD---------FGPQAFKLL 967

  Fly  1170 HIADV-------------LKGSKIKKIID-FNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLRE 1220
            ...|:             |:||..:::.| :..|..  .|..||..::......|:::.:|||.|
Human   968 SAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSL--FGTGKDQTESWWKAFSRQLITEGFLVE 1030

  Fly  1221 DLIFTNDFPQA---------YLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTA 1276
            ...: |.|.:.         :|:..|..|:.:....|.|....|....:...|            
Human  1031 VSRY-NKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTV------------ 1082

  Fly  1277 DGQSGMREIHERCYTDL-LDL----------------CRTIASQRNVTMASIMNIQALKSMAETL 1324
              .||.:   |.||..: ::|                |..|:|..|::..|||.....|:.:.:.
Human  1083 --SSGTK---EHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQ 1142

  Fly  1325 PITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQA-AAKQRPSTSGWNNE 1388
            |:..      ....:.....|| ||:|....:|::..:..|:|...:... .||.||:|.. |.:
Human  1143 PVIS------AQEQETQIVLYG-KLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVE-NVK 1199

  Fly  1389 SVDWDMAVASQGNA 1402
            .:|.    .|:|.|
Human  1200 RIDG----VSEGKA 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BlmNP_524319.2 RQC 1140..1253 CDD:286470 27/135 (20%)
HRDC 1286..1352 CDD:278967 17/82 (21%)
RecQ 729..1359 CDD:223588 198/682 (29%)
DEAD 739..908 CDD:278688 67/173 (39%)
HELICc 931..1061 CDD:238034 52/133 (39%)
RecQ_Zn_bind 1066..1134 CDD:292742 13/69 (19%)
WRNNP_000544.2 Interaction with WRNIP1. /evidence=ECO:0000250 2..277 21/95 (22%)
RNaseD_like 61..229 CDD:176650 5/19 (26%)
2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K 424..477 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..529 8/42 (19%)
recQ_fam 538..1010 CDD:129701 163/503 (32%)
DEAD 551..712 CDD:278688 67/173 (39%)
DEAH box 668..671 2/2 (100%)
HELICc 759..867 CDD:238034 45/107 (42%)
RecQ_Zn_bind 872..939 CDD:292742 13/69 (19%)
RQC 958..1051 CDD:214936 20/104 (19%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463 987..993 2/5 (40%)
HRDC 1156..1229 CDD:128635 18/60 (30%)
HTH_40 1261..1351 CDD:291179
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0514
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D445763at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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