Protein Alignment Blm and wrn

DIOPT Version :10

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: XP_012810306.2
• Gene: wrn / 734043
• XenbaseID: XB-GENE-992875
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1366
• Identity: 344/1366 - (25%)
• Similarity: 539/1366 - (39%)
• Gaps: 350/1366 - (25%)

  Fly   305 KENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAF-----DNSL--ADYLKDLAQNDNFSID- 361
            ||:.|..|  ..||.:.::.....|.  ||...|:.:     |.||  .|....|.:.|....|
 Frog    17 KEDSIDDK--KKSLWKKNIVEDNLPY--LKFNGSIVYSYEGNDCSLLSEDIRSSLQEEDVLGFDI 77

  Fly   362 ---PNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVMRQKFKA 423
               |.....:|.|..|     ..|.:.||.|.|      .|.:.:|||.              |.
 Frog    78 EWPPIYTKGKTGKVAL-----IQVCVSEKKCYL------FHISPMAGFP--------------KG 117

  Fly   424 RTQLVQNSLDKK--------ESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLPKV 480
            ..:|:::...||        :.:|.::.|...|..||: :|.|.|.:........:..:..|.|.
 Frog   118 LRRLLEDESVKKVGVGIEGDQWKLMSDYELKLKGFIEL-SEVANQKLRCKEKWSLNGLVKHLFKK 181

  Fly   481 QEIKDEKIPNRNQLIHDLCGEPDNFSPPSS---------------------------PRDTQLIP 518
            |.:||..|...|..|..|..:...::...:                           ..|.:.|
 Frog   182 QLLKDSSIRCSNWDIFPLSTDQKLYAASDAYAGLLIYQKLECMDAHEKVSFCVSRVGVADFEGI- 245

  Fly   519 KRQ---------QLINDLCGEPDDFSPPSKQNDPHLLR----------KCEE------------- 551
            |||         .|:.|:        |.|..:....||          |.||
 Frog   246 KRQLTDLSNGFMDLVKDV--------PSSFGHSTGALRAVAILEDLSEKLEELRSIVKEASKGEG 302

  Fly   552 ---LVHDL--CEEPDDY----LAQSMML-----DGDLEEEQLNGPTQGTTTSGMDDD-----EDD 597
               |.||.  |.|.|.|    ||...:|     |....|.:.|..........|..|     |::
 Frog   303 NGLLCHDSEDCSEEDKYQSINLASKELLAENKIDYKNAESKNNKDVDCCQNENMKQDFLGISEEE 367

  Fly   598 LEGLLAEIEDEHQKMQGRRSEFNGYSY-----KELEAVKVKEKHKETPINISLDD-DGFPEYDEA 656
            |. ::...:||.|...|::|  |.:.|     |.:..:...::..|:.|..||:| |.  ..:||
 Frog   368 LY-MMERKDDEKQIKPGQKS--NEHLYDTNEEKNMSYIIESDEEFESEIIKSLEDLDN--SIEEA 427

  Fly   657 MFEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQKF-- 719
            :...:|                 ...::|.|....:..::         .::||..|.|...:
 Frog   428 IGTSVH-----------------QTGLIPAKSVDTVADEE---------EDEGIEEEDDDDDWDP 466

  Fly   720 ---EHSTRLMHGLSYSFGLKSFRPNQLQVINATLL-GNDCFVLMPTGGGKSLCYQLPAILTEGVT 780
               |.:...:..|...||..||:|.|.:||::.|. ..|..|:|.||.|||||||...:.|.|:.
 Frog   467 SIPEPNAEQVSCLKTYFGHSSFKPVQWKVIHSVLRERRDNLVVMATGYGKSLCYQFAPVYTSGIG 531

  Fly   781 IVISPLKSLIFDQINKLASLDICAKSLSGEQK---MADVMAIYRDLESQPPMVKLLYVTPEKISS 842
            |||.||.||:.||:.:|...:|.:..|...|.   :.||.|         ..::::|:|||..|.
 Frog   532 IVICPLISLMEDQVLQLEMSNIPSCFLGSAQSKNVLQDVKA---------GRMRVIYMTPEFCSG 587

  Fly   843 SARFQDTLDTLNSNNY-ISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPR 906
            .......||    |.| |:...||||||:|:||||||..|:.||.||:..|.||.:||||||:|.
 Frog   588 GISLLQDLD----NRYGITLIAIDEAHCISEWGHDFRSAYRSLGSLKRMLPTVPIVALTATASPS 648

  Fly   907 VRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKP---QHFSG--IIYCL 966
            :|.||...|:|.|.:...:||:|.|| |..:.||..:...|:.:::..|.   ..|.|  |:||.
 Frog   649 IREDISKSLSLHNPQITCTSFDRPNL-YLDVAKKTTNISTDLQQFLIKKQGSGWEFEGATIVYCP 712

  Fly   967 SRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVL 1031
            :||..::.:.::.|.|:...:||||:....|......::..:::.:.|||||||||:|||:|.|:
 Frog   713 TRKTSEQVTAELTKLGIACGTYHAGMGIKQRRDVHHRFMRDEIQCVVATVAFGMGINKPDIRKVI 777

  Fly  1032 HYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKML---DSDKALQYNVKKIHVDNLY 1093
            ||..||.:|.||||.|||||||..:.|...:..:|:...:.||   .::...:|.:|.:.....|
 Frog   778 HYGAPKEMESYYQEIGRAGRDGLPSCCHALWTQADINFNRHMLGEIPNNSFREYKLKMLTKMEKY 842

  Fly  1094 RIVGYCENLTDCRRAQQLDYFGEHFTSEQC------LENRETACDNC---------IN------- 1136
            .      |.::|||...|    .||..:|.      :...|..||||         ||
 Frog   843 L------NSSNCRRKIIL----SHFEDKQLRKASSGIMGTEKCCDNCKTRLRFNISINDTEDNLQ 897

  Fly  1137 ---KRAYK---AVDALEHARKAARAVKDLCSGRSRFTLLHIADVLKGSKIKKIID-FNHHKTPHH 1194
               ::|||   |||.|  .:|....|..|              .|:||..:::.| |.||  |..
 Frog   898 EFGQQAYKFISAVDIL--GQKFGTGVPVL--------------FLRGSTSQRLPDRFRHH--PLF 944

  Fly  1195 GVLKDWDKNDVHRLLRKMVIDGFLRED-------------------------------LIFTNDF 1228
            ...||..:.....|.|:::.:|:|:|.                               |:.:||
 Frog   945 SCGKDQTEAFWKVLARQLISEGYLQESSGHTKFSTICGLTSKGTNWLMKASNQQHPSLLLPSND- 1008

  Fly  1229 PQAYL---YLGNNISK-------LMEGTPNFEFAVTKNAKE--------AKAAVGSVS---DGAT 1272
             :..|   .:.|:||:       :...:||...::.|...|        :....|.:|   |.:.
 Frog  1009 -ELCLRRTTVSNSISRVPSHSSMIPHASPNTRSSIPKAGPEKISLKEKFSYQEAGKLSTAVDVSK 1072

  Fly  1273 SSTADGQSGMR--------------EIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAET 1323
            ||:...|:..:              |:....|..|:...:.|||:|::..|.:...:.|..||:.
 Frog  1073 SSSLKLQTPCKPLQAAEPDVSPKEMELQTALYGRLVVARQKIASERDIPPAVLATNKVLVDMAKL 1137

  Fly  1324 LPITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLD---EEEEQAAAKQRPSTSGW 1385
            .|.|.::|..:..|::|. ....|.|:|:...:.....|...:..   .:.|..::.||...|..
 Frog  1138 RPTTIENMKKLDGVSEAK-SAMLAPLVEVVKEFCIANSLKMDIFSRSGSQSELTSSTQREQDSTT 1201

  Fly  1386 NNESVDWDMAVASQGNAN----------TSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAAR 1440
            ..||.....::..:.|.:          :..|.|.:.::|      .|:|.|...:.:..:|..|
 Frog  1202 LPESQRMSYSLFQEQNLSLKKVADARCLSMAAVGMHLWQA------LKAGYSVDVQRAGLTPGIR 1260

  Fly  1441 K 1441
            |
 Frog  1261 K 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RecQ	733..1217	CDD:440280	181/525 (34%)
		HRDC	1283..1357	CDD:470625	19/87 (22%)
wrn	XP_012810306.2	WRN_exo	55..222	CDD:176653	41/192 (21%)
		recQ_fam	477..950	CDD:129701	179/514 (35%)
		HRDC	1098..1176	CDD:128635	19/78 (24%)
		HTH_40	1205..1299	CDD:464189	11/63 (17%)