DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and RECQL

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_002898.2	Gene:	RECQL / 5965	HGNCID:	9948	Length:	649	Species:	Homo sapiens

Alignment Length:	705	Identity:	234/705 - (33%)
Similarity:	350/705 - (49%)	Gaps:	92/705 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 TTSGMDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFP 651
            :.|.:.::.|.:...|..:|.:.|::..|:.|.  ...|::...|:|:..:::      |.....
Human     3 SVSALTEELDSITSELHAVEIQIQELTERQQEL--IQKKKVLTKKIKQCLEDS------DAGASN 59

  Fly   652 EYDEAMFEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDG 716
            |||.       |.||.||
Human    60 EYDS-------SPAAWNK----------------------------------------------- 70

  Fly   717 QKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTI 781
            :.|..|.::...|...|.|:.|||.||:.||.|:.|.:.|::|||||||||||||||:.::|.|:
Human    71 EDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTL 135

  Fly   782 VISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARF 846
            ||.||.||:.||:..|..|.|.|..|:.......|..::.::.::...:||:|||||||:.|..|
Human   136 VICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMF 200

  Fly   847 QDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDI 911
            ...|:........:|..:||.||.||||||||||||.||:||::|||...|.||||||..|..|.
Human   201 MSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDA 265

  Fly   912 LAQLNLKNCKWFLSSFNRSNLRYRV--LPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDET 974
            ...|.::.|..|.:||||.||.|.|  .|......::||.:.|..:.:..||||||.|:|:.::.
Human   266 QKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQV 330

  Fly   975 SKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSI 1039
            :..:...|:.|.:|||.|...|:.:..:.|...:::|:.|||||||||||||||||:|:|:.||:
Human   331 TVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSM 395

  Fly  1040 EGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTD 1104
            |.||||:||||||...|||||||.:.|:.||..|:..:...|        ..||.:|.||:|::.
Human   396 ENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQ--------QKLYEMVSYCQNISK 452

  Fly  1105 CRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSGRSRFTLL 1169
            |||.....:|.|.:.||.|    ...||||....|::..:..|:.|...:.:|.......:.|.|
Human   453 CRRVLMAQHFDEVWNSEAC----NKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPL 513

  Fly  1170 HIADVLKGSKIKKIIDFNHHKTPHHGVL-KDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAYL 1233
            .:.|...|....|:        ...||: ....:.|:.:::...:|..:|:||..||.....:||
Human   514 KLIDSWMGKGAAKL--------RVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFTAYATISYL 570

  Fly  1234 YLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTADGQSGMREIHER 1288
            .:|...:.|..........|||:.:.:..|       .:|.|...:.|.:::.|:
Human   571 KIGPKANLLNNEAHAITMQVTKSTQNSFRA-------ESSQTCHSEQGDKKMEEK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	21/113 (19%)
		HRDC	1286..1352	CDD:278967	1/3 (33%)
		RecQ	729..1359	CDD:223588	213/563 (38%)
		DEAD	739..908	CDD:278688	83/168 (49%)
		HELICc	931..1061	CDD:238034	61/131 (47%)
		RecQ_Zn_bind	1066..1134	CDD:292742	21/67 (31%)
RECQL	NP_002898.2	recQ_fam	81..543	CDD:129701	195/481 (41%)
		DEAD	93..258	CDD:278688	81/164 (49%)
		DEVH box	219..222		2/2 (100%)
		HELICc	285..417	CDD:238034	61/131 (47%)
		RecQ_Zn_bind	422..478	CDD:292742	21/67 (31%)
		RQC	484..582	CDD:298958	21/105 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	595..649		5/31 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360651at33208
OrthoFinder	1	1.000	-	-		FOG0001239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100352
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R580
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750