DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and blm

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_017207538.1	Gene:	blm / 572540	ZFINID:	ZDB-GENE-070702-5	Length:	1450	Species:	Danio rerio

Alignment Length:	1592	Identity:	483/1592 - (30%)
Similarity:	720/1592 - (45%)	Gaps:	314/1592 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NSQSQPKSRAASVRSKPPAVYNPIFLDASSSDDETTEISSQSNNGTIATKKSSRDPRTAKLKKHT 87
            |:.:|  ::.:.::.||...   .|...|||.....|:..:....::...:|...|...::.|:.
Zfish    28 NNAAQ--NKLSLLKPKPGGF---CFKKKSSSGISKVEVPQKVTGSSVLANRSVNIPSNFEVTKNP 87

  Fly    88 YLDLSVSPLAKLSAKKYARDSPKKPTSLDLSVSPLAE-------LLAKKSDRDSPKK---PVQNE 142
             :..|..| .:::.|.....:|.||.:  .:|:|||.       .|.:.:.:..||.   |..:.
Zfish    88 -VTFSQKP-ERVAPKVNFFTAPSKPKT--NTVNPLANPFALNKTPLVQSTIKALPKSAALPKDST 148

  Fly   143 NSYTYR------GLS----------ESPVENK----SIGDTLRKPPQKERKTSIVWLSDSPEKKV 187
            |..|..      .||          |:||:::    ..|.:.:||...::.||....|...|.||
Zfish   149 NDQTVELKHDISQLSFNEWDDLDDFETPVKSRVASPVAGTSTKKPSVSDQNTSSSCSSKCEETKV 213

  Fly   188 TQNER--KILDSPLQRFSFEDFPNKENGNRHHLLTLPDSPPPPQPVKK---PEKTMWQN------ 241
            .:..:  :.:.:|....|..:..:.|...|.         |...|:||   |:|::...
Zfish   214 NEESQATETITAPKDVLSAANGVSTETAERE---------PEDSPIKKSKRPKKSVQHTALLSDT 269

  Fly   242 ------------------ETKTIQDKDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDS 288
                              ::..:.:||....|.|.::        |.....|.|:|     |||.
Zfish   270 EDEEIIHCVSPDTNQKNFKSVAVAEKDKWGEPNVIDS--------DDCEENNHYEG-----FEDF 321

  Fly   289 PEKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDLA 353
            ...|...|: ..|..:.:.:..::|.|.:.::.|..|:....|||        |.| |..||. |
Zfish   322 IPPSPIPEE-ISLSVSDKEKSSSEPVTPANKKESSRSASGLPAPL--------DQS-AKGLKG-A 375

  Fly   354 QNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVMR 418
            .:..||:                        ||..|.|:|.||.   :|:......|.|.|:...
Zfish   376 DDALFSV------------------------MESICCLVDTIPE---HELIALTCGTELLLQRAH 413

  Fly   419 QKFKARTQLVQNSLDKKESQLKAEQEALEK----------------EEIEMQAEQAQQTVLSSSS 467
            :|         ..|.|..|...:..:::..                ..:.......::.|.:..|
Zfish   414 RK---------RILAKGGSSRTSHSDSVSTPGFLNRPTFGVTPSNLTSLTPVTSGKREGVKTGFS 469

  Fly   468 PEKSRPIMPLPKVQEIKDEKI-PNRNQLIHDL-----CGEPDNFSPPSSPRDT-----QLIPKRQ 521
            ..||     :..|..:.||.: .:.:.:|:.:     ...|::.:..|:.|||     |.:.|.:
Zfish   470 FRKS-----IASVMSVGDESVFEDSDCIINGVETPGGTWNPNSSTKISAGRDTFNGSIQTLSKPE 529

  Fly   522 QLINDLCGEPDDFSPPSKQNDPHLLRKCEELVHDLCEEPDDYLAQSMMLDGDLEEEQLNGPTQGT 586
            .. .|.|.....|:..|.|.             ||...|....:.|...|..:|.......:..|
Zfish   530 SK-TDKCYSRLSFNESSNQT-------------DLFYSPKRVDSGSRNADSSVEINIAGSSSLRT 580

  Fly   587 TTSGMDD---DEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDD 648
            ....:||   |:.|::                                            ..|::
Zfish   581 GAEPVDDFLLDDFDID--------------------------------------------DFDEN 601

  Fly   649 GFPEYDE---AMFEQMHSQAAANKSRVSSAGPSTS---KSVVP--TKQTSALHSQKLSGNFHANV 705
            ..|:|.|   ::.|..::......| |...|.|.|   |:..|  .|.....:.:.|    :.|.
Zfish   602 DIPDYYEEPPSVLESRNNSGVKTPS-VQEGGSSKSFERKTFTPPAPKSIKTPNPEPL----YRNP 661

  Fly   706 HNDGITGEFDGQKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQ 770
            .:|    .|.|..|.||..:|......|||..||.|||:.|||:|||.|.|||||||||||||||
Zfish   662 AHD----RFRGFNFPHSPEMMKIFHKKFGLHQFRFNQLEAINASLLGEDTFVLMPTGGGKSLCYQ 722

  Fly   771 LPAILTEGVTIVISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYV 835
            |||.::.|||:|||||:|||.||:.||.:|||||.||||::|.::...||..|..:.|.:||||.
Zfish   723 LPACVSAGVTVVISPLRSLIVDQVQKLTTLDICATSLSGDKKDSEAARIYMQLSRKDPAIKLLYA 787

  Fly   836 TPEKISSSARFQDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALT 900
            ||||:.:|.|....|..|.....::|.||||||||||||||||||||:|..|::.|||||.:|||
Zfish   788 TPEKVCASGRMISALQNLYERGLLARLVIDEAHCVSQWGHDFRPDYKRLHELRRMFPNVPIMALT 852

  Fly   901 ATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYC 965
            |||||||:.|||.||.:...:.|..||||:||:|.|||||.....::..::|:......|||:||
Zfish   853 ATATPRVQKDILNQLAMTRPQVFTMSFNRNNLKYSVLPKKPKKVDEECIQWIKKYYPRDSGIVYC 917

  Fly   966 LSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLT-GKMRVICATVAFGMGIDKPDVRF 1029
            |||.:||..:..:.:.|:.|::|||||:|:|||..|..|:. ...:|:|||:||||||||||||:
Zfish   918 LSRNDCDTLADSLQRAGIAALAYHAGLSDSDREYVQNKWINQDGCQVMCATIAFGMGIDKPDVRY 982

  Fly  1030 VLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYR 1094
            |:|.|||||:||||||:|||||||:::.|:|:|:|||::|||:::..||......|..|::||:.
Zfish   983 VIHASLPKSVEGYYQESGRAGRDGEISHCVLFYSYSDVIRIKRLIAMDKDGNQQSKATHINNLHS 1047

  Fly  1095 IVGYCENLTDCRRAQQLDYFGEH-FTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKD 1158
            :|.:|||:.:|||.|.|.||||| |.:..|.|:.|..||||.....||:.:..:..:|.||.|:|
Zfish  1048 MVHFCENVAECRRIQLLAYFGEHTFNTSFCKEHPEVICDNCARPNKYKSRNVTDDVKKIARFVQD 1112

  Fly  1159 LCS------GRS----RFTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMV 1213
            .|.      |:|    |.||..:.::..|||..:|      :|...||...:.|::..||.:|:|
Zfish  1113 NCEKVGNRYGKSAQQNRLTLNMLVEIFLGSKSARI------QTGMFGVGAAYSKHNAERLFKKLV 1171

  Fly  1214 IDGFLREDLIFTNDFPQ-AYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTAD 1277
            :|..|.|||..||.... ||:..|.....::.|....||..|::|...:....||.:..
Zfish  1172 LDNVLMEDLYITNSGQAVAYISAGPKAMSVLNGCMQVEFHETESASSIRKHRASVCEKV------ 1230

  Fly  1278 GQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHVTKANF 1342
              |...|:.::|..:|.|||:.:.....:...:|.:...||.:||||....:.:..|..||:...
Zfish  1231 --SKREEMVKKCLGELNDLCKKLGKVFGIHYYNIFSTATLKKIAETLSADPEVLLQIDGVTEDKL 1293

  Fly  1343 DKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGW-------NNESVDWDMAVASQG 1400
            :||||:.:|:...|:             |.|..|:.:..:|||       .|:..|.|......|
Zfish  1294 EKYGAEFIELLQKYS-------------EWQLPAEAQAESSGWIDTTRGHQNDEDDNDDDDEGGG 1345

  Fly  1401 NANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAARK------TTSARG-------RGGRA 1452
            :. ||.....||.|..|||:...|...||.|.|:...::.|      .:|:||       |||..
Zfish  1346 DV-TSTYFRSNSGRGAKRKQGSYSRKPKRRKGSSGQNSSAKGGYSSNWSSSRGGGRGGGYRGGSR 1409

  Fly  1453 GAKRAESSASSASGWKSKKTGNSFGFDLMPLP 1484
            ||.|...||.|.|..|..      ||..:|.|
Zfish  1410 GAGRGSRSAPSGSAAKRP------GFMSLPTP 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	38/123 (31%)
		HRDC	1286..1352	CDD:278967	19/65 (29%)
		RecQ	729..1359	CDD:223588	292/642 (45%)
		DEAD	739..908	CDD:278688	107/168 (64%)
		HELICc	931..1061	CDD:238034	69/130 (53%)
		RecQ_Zn_bind	1066..1134	CDD:292742	30/68 (44%)
blm	XP_017207538.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595601
Domainoid	1	1.000	218	1.000	Domainoid score	I2606
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I981
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360651at33208
OrthoFinder	1	1.000	-	-		FOG0001239
OrthoInspector	1	1.000	-	-		oto38763
orthoMCL	1	0.900	-	-		OOG6_100352
Panther	1	1.100	-	-	LDO	PTHR13710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760