Protein Alignment Blm and wrn

DIOPT Version :9

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: XP_009302246.2
• Gene: wrn / 569495
• ZFINID: ZDB-GENE-070702-2
• Length: 1387
• Species: Danio rerio
• Alignment Length: 1287
• Identity: 304/1287 - (23%)
• Similarity: 504/1287 - (39%)
• Gaps: 327/1287 - (25%)

  Fly   385 MEKYCSLIDQIPAMHFNEIAGFQPNTFLKLK---VMRQKFKARTQLVQNSLDKKESQLKAEQEAL 446
            |.:.|:..|:....|.:.::||.|...:.|:   :|:         |...::..:.:|.::.:..
Zfish    87 MVQLCASEDKCYLFHISSMSGFPPGLKMFLEDENIMK---------VGVGIEGDKWKLLSDYDIK 142

  Fly   447 EKEEIEMQAEQAQQTVLSSSSPEKSR---------PIMPLPKVQEIKDEKIPNRNQLIHDLCGEP 502
            .|..::          ||..:.||.|         .:..|.|.|..||:.:         .|...
Zfish   143 LKNIVD----------LSDLANEKLRCCEKWSLDGLVKHLLKKQLFKDKLV---------RCSHW 188

  Fly   503 DNFSPPSSPR---------DTQLIPKRQQLINDLCGEPDDFSPPSKQNDPHLLRKCEELVHDLCE 558
            |:||.....:         ...:..|.|::|:...|..   :|..|:....:....::|...:..
Zfish   189 DDFSLTEDQKRYAATDAYAGLLIYQKLQEMISGCSGSS---APSLKERVLKIACDLKDLADHIPN 250

  Fly   559 EPD---------DYLAQSM------MLDGDLEEEQL--NGPTQGTTTSGMDDDEDDLEGLLAEIE 606
            |.|         |.|:|::      :.:.:...|||  ..|:.|..   :||.....||:....|
Zfish   251 ELDCTDGAGRLVDDLSQTLTSLRCVLSNANKPTEQLVEEKPSPGLI---LDDTSSHHEGVPTTEE 312

  Fly   607 DEH-----------QKMQGRRSEFNGYSYKELEAVKVKE------------KHKETP--INISLD 646
            ..|           |:......:.:.|..:.||....:|            :|...|  :|.:..
Zfish   313 QSHSQCVENPGRPPQRECAMSLDISEYELQMLEEQARQEQLEEECILAFQTQHASGPQDLNATES 377

  Fly   647 DDGFPEYDEAMFEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGIT 711
            |:   |:|:.|.:........|.:::..:|.......|...:...|.|              .|.
Zfish   378 DE---EFDDEMMKCADDIEKINNAQMPQSGAEDEDEDVEENEEEGLDS--------------SIP 425

  Fly   712 GEFDGQKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLL-GNDCFVLMPTGGGKSLCYQLPAIL 775
            .....|        :..|...||..||:|.|.:||.:.|. ..|..|:|.||.|||||:|.|.:.
Zfish   426 QPVPEQ--------IKCLKMFFGHHSFKPVQWKVIQSILTERRDNLVVMATGYGKSLCFQFPPVY 482

  Fly   776 TEGVTIVISPLKSLIFDQINKLASLDICA--------KSLSGEQKMADVMAIYRDLESQPPMVKL 832
            .:.:::|||||.:|:.||:.:|...:|.|        |:|:.:.|..|              .::
Zfish   483 CQTISVVISPLIALMEDQVLQLTMSNIPACFLGSAQTKNLNEQVKRGD--------------FRV 533

  Fly   833 LYVTPEKISSSARFQDTLD-TLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPT 896
            :|:|||..|.:......|| |:.    :|...:|||||:||||||||..|::||.|||..|.||.
Zfish   534 VYMTPEFCSGNIPLLVQLDRTVG----LSLIAVDEAHCISQWGHDFRSAYRELGKLKKNLPTVPF 594

  Fly   897 IALTATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKP---QH 958
            :||||||:|.:|.||:..|:|.|.....:||:|.|| |..:.:|....:.|:.|::..|.   ..
Zfish   595 LALTATASPSIRDDIIKSLHLINPMITCTSFDRPNL-YLDVNRKSGDVIQDLKRFLVKKKGGGYE 658

  Fly   959 FSG--IIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMG 1021
            |.|  |:||.|:||.:..:..:.|..:....|||||:...|...|..::..:::.:.||||||||
Zfish   659 FEGSAIVYCPSKKEAERVTTALFKLDIPCGVYHAGLSIKQRRETQHQFMRDEIQCVVATVAFGMG 723

  Fly  1022 IDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKK 1086
            |:|.|:|.|:||..||.:|.||||.|||||||..:.|.:.:...||...|.:|:..|:.::...|
Zfish   724 INKSDIRKVIHYGAPKEMESYYQEIGRAGRDGLPSACHVLWMPGDMALNKFILNQSKSERFRSYK 788

  Fly  1087 IHVDNLYRIVGYCENLTDCRRAQQLDYFGEH---------FTSEQCLENRETACDNC---INKRA 1139
            |  |.:.::..|. |.|.|||...|.:|.:.         ..|.||       ||||   :|:..
Zfish   789 I--DMMAKMEKYL-NSTKCRRKLILCHFEDKRLRKVTSGILGSSQC-------CDNCRSGVNEED 843

  Fly  1140 YKAVDALEHARKAARAVKDLCSGRSRFTLLHIADVLKGSKIKKIID-FNHHKTPHHGVLKDWDKN 1203
            .:.:.. :....|.:.:|.:.....||.:......|:||..:::.: |..|..  .|:.:|..:.
Zfish   844 LEVLQQ-DFGLCAYQLMKAISVMEERFGITAPILFLRGSCSQRVPERFRKHSL--FGIGRDVSET 905

  Fly  1204 DVHRLLRKMVIDGFL-------------------REDLIFTNDFPQAYLYLGNN----------- 1238
            ....|.|:::.:.:|                   |..|....|.....|.|..|
Zfish   906 WWKALGRELIAEKYLMEVTGHSKFTTLCKITTKGRSWLSKAEDEKHRQLLLQPNRDLFSRVCAPR 970

  Fly  1239 -----------ISKLMEGTPNFE-----FAVTKNAKEAKAAV--GSVSDGATSSTADGQSGMR-- 1283
                       :|.|.  :|:..     |..||...|:...|  |.:...:.:.....|:.:|
Zfish   971 RKADPAQVEPTVSNLQ--SPHIRPSLVTFQRTKLGSESPQIVKKGDLPSRSAARQTQIQTDVRAQ 1033

  Fly  1284 ---------EIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHVTK 1339
                     ::....|..|:...:.:||.|::..|.:...:.|..|::..|.|...:..:..|::
Zfish  1034 TPGASAKEIQLQSELYGKLVSERQKLASIRDIPPALLATNKILLDMSKLRPCTMSSLKQVDGVSE 1098

  Fly  1340 -------------ANFDKYGAKLLEITSNYAS--------------------------------- 1358
                         |.|.:.....::::||.||
Zfish  1099 AKAAMLTPLIDIIAKFCQTHGLQVDVSSNSASSVQTHSCRESVVGSVAQCLPDSISITYSLFQTE 1163

  Fly  1359 EKLLMQ---------AVLDEEEEQAAAKQRPSTSGWNNESVDWDMAVASQGNANT----SGASGF 1410
            .|.|.|         ||::....||   |:...      :||.|.|..|....||    :..|..
Zfish  1164 HKSLRQVSDARSLPIAVVESHLLQA---QKMGC------AVDTDRAGLSTSIMNTIRKNTAGSDL 1219

  Fly  1411 NSFRAGK------------RKKIY----KSGASKRYKTSTTSPAARKTTSAR 1446
            ..|:|.:            |..||    ::.::.|::.|...|..:.||:.|
Zfish  1220 CDFKAVRSRVPEDISNFLLRLAIYELQKEASSTTRHEISWIEPLDKSTTATR 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	24/159 (15%)
		HRDC	1286..1352	CDD:278967	13/78 (17%)
		RecQ	729..1359	CDD:223588	209/762 (27%)
		DEAD	739..908	CDD:278688	70/178 (39%)
		HELICc	931..1061	CDD:238034	53/134 (40%)
		RecQ_Zn_bind	1066..1134	CDD:292742	21/76 (28%)
wrn	XP_009302246.2	WRN_exo	48..217	CDD:176653	27/157 (17%)
		DEXDc	433..901	CDD:331760	171/499 (34%)
		HRDC	1045..1116	CDD:322002	13/70 (19%)
		HTH_40	1155..1242	CDD:316965	19/95 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920