DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and recql

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_031753791.1	Gene:	recql / 549070	XenbaseID:	XB-GENE-1017313	Length:	654	Species:	Xenopus tropicalis

Alignment Length:	682	Identity:	240/682 - (35%)
Similarity:	349/682 - (51%)	Gaps:	87/682 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 MDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDE 655
            ||.:|      .|.:.||.:.:.           .||:||:::                ..|..|
Frog     1 MDSEE------AAALVDELESVS-----------SELQAVEIQ----------------LQELLE 32

  Fly   656 AMFEQMHSQAAANK--SRVS-SAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQ 717
            ...|.:..:...||  .|:| .:||.||..    ...||.:.||                    :
Frog    33 RQQELIQRKRLLNKKIQRLSEDSGPGTSAG----GGDSAENWQK--------------------E 73

  Fly   718 KFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIV 782
            .|..|.::...|..||.|:|||..||:.||||:.|.|.|::|||||||||||||||:.::|.|:|
Frog    74 DFLWSQKIRDALCNSFQLRSFRSLQLETINATMAGRDVFLIMPTGGGKSLCYQLPAVCSDGFTLV 138

  Fly   783 ISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQ 847
            |.||.||:.||:..|..|.:.|.||:.......|..::.::.::...:||||||||||:.|..|.
Frog   139 ICPLVSLMEDQLMVLDRLGVSATSLNASSSKEHVKWVHGEMTNKNSRLKLLYVTPEKIAKSKLFM 203

  Fly   848 DTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDIL 912
            ..|:.......::|..:||.||.||||||||||||.||:||::|||.|.|.||||||..|..|..
Frog   204 SRLEKAYQAGLLARVAVDEVHCCSQWGHDFRPDYKTLGILKRQFPNSPLIGLTATATTHVLKDAQ 268

  Fly   913 AQLNLKNCKWFLSSFNRSNLRY--RVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDETS 975
            ..|.:.....|.:||||.||.|  |:.|......:.||.:.|.|:.:..||||||.|:|:.:..:
Frog   269 KILCVPKPLTFTASFNRPNLFYEVRLKPSSSQDFIADIVKLINSRYRGQSGIIYCFSQKDSEHVT 333

  Fly   976 KKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIE 1040
            ..:.|.|:||.:|||.:...|:......|...:::::.|||||||||||||||||:|:|:.||:|
Frog   334 MSLQKLGIRAGTYHANMEPRDKTKVHTKWTANEIQIVVATVAFGMGIDKPDVRFVIHHSMSKSME 398

  Fly  1041 GYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDC 1105
            .||||:||||||...|||||||.:.|:.||..|:..:...|   ||     ||.:||||::...|
Frog   399 NYYQESGRAGRDDARADCILYYGFGDIFRISSMVVMENVGQ---KK-----LYEMVGYCQSPDRC 455

  Fly  1106 RRAQQLDYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSGRSRFTLLH 1170
            ||.....:|.|.:.|.:|    ...||||.::..::..|...:.|...:.::.......:.|.|.
Frog   456 RRVLIAQHFDEVWDSAKC----NKMCDNCNSEGGWEKADITPYCRDIVKILEQANQMDEKLTPLK 516

  Fly  1171 IADVLKGSKIKKIIDFNHHKTPHHGVL-KDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAYLY 1234
            :.|...|..:.|:      :.|  ||. ....:.::.|::..:::..|||||..||.....:|:.
Frog   517 LMDAWVGKGVAKL------RVP--GVRPPQLPRPEIERIIAHLLLQQFLREDFSFTAYATISYIK 573

  Fly  1235 LGNNISKLMEGTPNFEFAVTKNAKEAKAAVGS 1266
            .|..:..|...    ::|:....:...|..|:
Frog   574 RGPKVDLLRSD----KYAICLPMRSGGAGAGA 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	21/113 (19%)
		HRDC	1286..1352	CDD:278967
		RecQ	729..1359	CDD:223588	213/541 (39%)
		DEAD	739..908	CDD:278688	86/168 (51%)
		HELICc	931..1061	CDD:238034	62/131 (47%)
		RecQ_Zn_bind	1066..1134	CDD:292742	22/67 (33%)
recql	XP_031753791.1	recQ_fam	83..539	CDD:129701	199/475 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360651at33208
OrthoFinder	1	1.000	-	-		FOG0001239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010