DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and RecQ4

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster

Alignment Length:	1681	Identity:	344/1681 - (20%)
Similarity:	555/1681 - (33%)	Gaps:	616/1681 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DPRTAKLKKHTYLDLSVSPLAKLSAKKYARDSPKK----PTSLDLSVSPLAELLAKKSDRDSPKK 137
            |....|||...|         ||..|.:.:|..||    |:..|:..       |.:..|||.|.
  Fly     2 DDSVFKLKYQKY---------KLRVKVWEKDFKKKNGRVPSKYDIRD-------ASQEIRDSYKM 50

  Fly   138 PVQNENSYTYRGLSESPVENKSIGDTLRKPPQKERKTSI----VWLSDSPEKKVTQNERKILDSP 198
            ..:.:.|:....|::  |.::...|.|......:...|:    |.|::.|:..:   :...|..|
  Fly    51 YYKLKTSFLEETLND--VLSEDGYDILEMSQASDFGVSMLDQDVSLNEGPQLPL---DISALVGP 110

  Fly   199 LQRFSFEDFPNKENGNRHHLLTLPD---------------------------------------S 224
            ....:.|:.|....|:..:|:.||:                                       .
  Fly   111 QSSGNLEEIPQSVEGSFSNLIDLPNRQVLTNLVNRDENHVIRKFEAVEELPINQNAWGLNVSKKP 175

  Fly   225 PPPPQPVKKPEKTMWQNETKTIQDKDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSP 289
            |.|||||:              ..|.:|.:.......||:...|            |..||:.|
  Fly   176 PAPPQPVE--------------ASKSAPGHGKQPKAGASLKPSL------------SAKLFQSS- 213

  Fly   290 EKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSL---ADYLKD 351
                       .|.||.|  |.||.:..:..:|.|:|.|..........:.|:..|   |...|:
  Fly   214 -----------RGFAKRN--PRKPLSRCVSSSSSTTSLSSVPTDHHEELLDFETILIRKAQEYKE 265

  Fly   352 ----LAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFL 412
                :|.|...:.:.:|::.:||.......|||      |..:|.:::|....|..:|...
  Fly   266 KQQAIANNPMLASEHSKESIKTLVDDGWLRRNT------KENTLDEEVPFAEANNNSGTSK---- 320

  Fly   413 KLKVMRQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPL 477
                     |....|....|.|.:..:| |::.|:.:..:|...|..||.::||..:|...:...
  Fly   321 ---------KTNFGLANLDLSKLKPTVK-EEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHT 375

  Fly   478 PKVQEIKDEKIPNRNQLIHDLCGEPDNFSPPS-------------------SPRDTQLIPKRQQL 523
            |.....|..              .|.|..|||                   .|::.:.:.||:::
  Fly   376 PPASSQKSV--------------APKNKPPPSEQETDSDSDSVVAESEEEQEPQEYRQLSKRRKI 426

  Fly   524 INDLCG--------------EPD---------DFS----------PPSKQND------------- 542
            ::...|              ||:         |||          |.:|:.|
  Fly   427 VSTASGKVEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPENKKKDKAKRKQAAGKQKT 491

  Fly   543 ----------------------------PHLLRKC-------------------EELVHDLCEEP 560
                                        |...:|.                   |:|.:.|..|.
  Fly   492 TKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAPDPEEDERQPLNPEDLKYVLALEA 556

  Fly   561 DDYLAQSMMLDGDLEEEQLN----------GPTQGTTTSG---MDD---------DEDDLEGLLA 603
            .|..:...:...||||....          ||..|.:...   :|:         :|....|.|.
  Fly   557 GDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLN 621

  Fly   604 E----IEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKE-------------------------- 638
            |    |..:.:|....:...|...||     |.:.:||:
  Fly   622 ENFVTINIQKKKFVRGKKSVNFSKYK-----KQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCG 681

  Fly   639 ----------------TPINISLDDD--GFPEYDEAMFEQMHSQAA--ANKSRVSSAGPSTSKSV 683
                            .|::..|::|  .||...||  ::|.||.|  |:...:|....:.:.::
  Fly   682 GVGHFAQQCKVKGDSLLPLSAQLEEDPSPFPTLAEA--QEMASQGAVVAHSRNISRLPQAANAAI 744

  Fly   684 VPTKQ--TSALHSQKLSGNFHANVH------NDGITGEFD------------------------- 715
            :...:  .|....|:.||:.....|      :|.:..:|:
  Fly   745 LQGDELNESEEDDQESSGDEEVQQHPDPNWSSDEMDVDFEALDAAVEASLSQPVSQEKAASPIKT 809

  Fly   716 --GQKF--------------EHSTRLMHG-----------------------LSYSFGLKSFRPN 741
              |.|.              ..|.|..||                       ..:.||..:||..
  Fly   810 YVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALHMFGHTNFRKG 874

  Fly   742 QLQVINATLLGNDCFVLMPTGGGKSLCYQLPAIL----TEGVTIVISPLKSLIFDQINKLASLDI 802
            |.:.|..||.|....|.:.||.||||||||||.|    ...:|:|||||.||:.||:..:... :
  Fly   875 QDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF-L 938

  Fly   803 CAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEA 867
            .|..|...|.....|.|.:.:.:..  :.:|.|:||.:.:..|.......|.....|:...||||
  Fly   939 RAHCLHTNQTAPQRMKIQQMIANGE--IDILLVSPEAVVAGERATGFGAILRQLPPIAFACIDEA 1001

  Fly   868 HCVSQWGHDFRPDYKKL-GVLKKRFPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSN 931
            ||||||.|:|||.|..: .||:|.......:.||||||...|:.|:..|.       :|...|..
  Fly  1002 HCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLG-------ISDGERGI 1059

  Fly   932 LRYRVLPKKGV-STLDDISRYI---------RSKPQHFSGIIYCLSRKECD-------------- 972
            :....||...| |...|.:|..         |.:|.. |.||||..|.||:
  Fly  1060 ISDIPLPDNLVLSVSKDENRDAALLQLLNSERFEPCQ-SIIIYCTRRDECERIAGFIRTCVQDRR 1123

  Fly   973 ----ETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHY 1033
                :.:||..:...:|..||||:..:.|.:.||.:::.::|::.||:||||||:|||:|.|:||
  Fly  1124 EPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHY 1188

  Fly  1034 SLPKSIEGYYQEAGRAGRDGDVADCILYYNY--SDMLRIKKMLDSDKALQYNVKKIHVDNLYRIV 1096
            ::|::.|.|.||.|||||||..:.|.|:.:.  .|...:::.:.|:...::.::|: :..:: :.
  Fly  1189 NMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKL-LQKIF-VP 1251

  Fly  1097 GYCENLTDCRRAQQLDYFGE---------H---FTSEQCLENRETACDNCINKRAYKAVDA---- 1145
            ..|:.....|.|..:...|:         |   |:.|:.:|..:...:|......|..:|.
  Fly  1252 CSCDKEASKRTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRWCI 1316

  Fly  1146 --------------------LEHARK--------AARAVKDLC----SGRSRFTLLHIA------ 1172
                                |:||.|        .|..::|..    |....|::..||
  Fly  1317 SVLSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGIGWN 1381

  Fly  1173 -DVLK---------------------------GSKIKKIIDFNHHKTPH---------------- 1193
             .|:|                           |.:||...||...:..:
  Fly  1382 SGVVKYQLKDLEWVKVNGYPKRSPITVSFYDLGFRIKVPGDFTESEIDNALDTLYTRSVKQERTQ 1446

  Fly  1194 --------HGVL------------KDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAY------ 1232
                    ||:.            .|:.::...:|  |.::..:      |.||:||..
  Fly  1447 LIQLQYVAHGLAAVAYSSCGQCCNADFPQDRGEQL--KAIVRNY------FANDYPQDLELEIEP 1503

  Fly  1233 ----------------------LYLGNNISKLMEG--TPNFEFAVTKNAKEAKAAV 1264
                                  .:.|.||:::..|  :||:...:....|..:|.|
  Fly  1504 SNVPDENIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNYPAVIWGRCKFWRAHV 1559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	35/248 (14%)
		HRDC	1286..1352	CDD:278967
		RecQ	729..1359	CDD:223588	180/719 (25%)
		DEAD	739..908	CDD:278688	66/173 (38%)
		HELICc	931..1061	CDD:238034	55/157 (35%)
		RecQ_Zn_bind	1066..1134	CDD:292742	11/79 (14%)
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279	15/61 (25%)
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	130/364 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850